ID E0NAP9_NEIME Unreviewed; 392 AA.
AC E0NAP9;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2010, sequence version 1.
DT 24-JAN-2024, entry version 42.
DE SubName: Full=Efflux transporter, RND family, MFP subunit {ECO:0000313|EMBL:EFM03900.1};
GN Name=macA {ECO:0000313|EMBL:EFM03900.1};
GN ORFNames=HMPREF0602_1581 {ECO:0000313|EMBL:EFM03900.1};
OS Neisseria meningitidis ATCC 13091.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC Neisseria.
OX NCBI_TaxID=862513 {ECO:0000313|EMBL:EFM03900.1, ECO:0000313|Proteomes:UP000005526};
RN [1] {ECO:0000313|EMBL:EFM03900.1, ECO:0000313|Proteomes:UP000005526}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 13091 {ECO:0000313|EMBL:EFM03900.1,
RC ECO:0000313|Proteomes:UP000005526};
RA Muzny D., Qin X., Deng J., Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L.,
RA Thornton R., Coyle M., Francisco L., Jackson L., Javaid M., Korchina V.,
RA Kovar C., Mata R., Mathew T., Ngo R., Nguyen L., Nguyen N., Okwuonu G.,
RA Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W., Jakkamsetti A.,
RA Pham P., Ruth R., San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C.,
RA Zhu D., Lee S., Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S.,
RA Hirani K., Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S.,
RA Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L.,
RA Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P.,
RA Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K.,
RA Petrosino J., Highlander S., Gibbs R.;
RL Submitted (JUL-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC family. {ECO:0000256|ARBA:ARBA00009477}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFM03900.1}.
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DR EMBL; AEEF01000078; EFM03900.1; -; Genomic_DNA.
DR RefSeq; WP_002214393.1; NZ_GL397187.1.
DR AlphaFoldDB; E0NAP9; -.
DR GeneID; 61280762; -.
DR HOGENOM; CLU_018816_14_1_4; -.
DR Proteomes; UP000005526; Unassembled WGS sequence.
DR GO; GO:0019898; C:extrinsic component of membrane; IEA:InterPro.
DR GO; GO:1990195; C:macrolide transmembrane transporter complex; IEA:InterPro.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:1990961; P:xenobiotic detoxification by transmembrane export across the plasma membrane; IEA:InterPro.
DR Gene3D; 2.40.30.170; -; 1.
DR Gene3D; 2.40.420.20; -; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 6.10.140.1990; -; 1.
DR InterPro; IPR032317; HlyD_D23.
DR InterPro; IPR030190; MacA_alpha-hairpin_sf.
DR InterPro; IPR006143; RND_pump_MFP.
DR NCBIfam; TIGR01730; RND_mfp; 1.
DR PANTHER; PTHR30469:SF33; EFFLUX PROTEIN; 1.
DR PANTHER; PTHR30469; MULTIDRUG RESISTANCE PROTEIN MDTA; 1.
DR Pfam; PF16576; HlyD_D23; 1.
DR PRINTS; PR01490; RTXTOXIND.
DR SUPFAM; SSF111369; HlyD-like secretion proteins; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils}.
FT DOMAIN 43..265
FT /note="RND efflux pump membrane fusion protein barrel-
FT sandwich"
FT /evidence="ECO:0000259|Pfam:PF16576"
FT COILED 105..177
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 392 AA; 41745 MW; BC88F24B0CB9E5DE CRC64;
MAKMMKWAAV AAVAAAAVWG GWSYLKPEPQ AAYITETVRR GDISRTVSAT GEISPSNLVS
VGAQASGQIK KLYVKLGQQV KKGDLIAEIN STSQTNTLNT EKSKLETYQA KLVSAQIALG
SAEKKYKRQA ALWKDDATSK EDLESAQDAF AAAKANVAEL KALIRQSKIS INTAESELGY
TRITATMDGT VVAILVEEGQ TVNAAQSTPT IVQLANLDMM LNKMQIAEGD ITKVKAGQDI
SFTILSEPDT PIKAKLDSVD PGLTTMSSGG YNSSTDTASN AVYYYARSFV PNPDGKLATG
MTTQNTVEID GVKNVLIIPS LTVKNRGGKA FVRVLGADGK AAEREIRTGM RDSMNTEVKS
GLKEGDKVVI SEITAAEQQE SGERALGGPP RR
//
