ID E0NNR4_9FIRM Unreviewed; 510 AA.
AC E0NNR4;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase {ECO:0000313|EMBL:EFM24567.1};
DE EC=6.3.2.10 {ECO:0000313|EMBL:EFM24567.1};
GN Name=murF {ECO:0000313|EMBL:EFM24567.1};
GN ORFNames=HMPREF9225_1803 {ECO:0000313|EMBL:EFM24567.1};
OS Peptoniphilus duerdenii ATCC BAA-1640.
OC Bacteria; Bacillota; Tissierellia; Tissierellales; Peptoniphilaceae;
OC Peptoniphilus.
OX NCBI_TaxID=862517 {ECO:0000313|EMBL:EFM24567.1, ECO:0000313|Proteomes:UP000003280};
RN [1] {ECO:0000313|EMBL:EFM24567.1, ECO:0000313|Proteomes:UP000003280}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-1640 {ECO:0000313|EMBL:EFM24567.1,
RC ECO:0000313|Proteomes:UP000003280};
RA Muzny D., Qin X., Deng J., Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L.,
RA Thornton R., Coyle M., Francisco L., Jackson L., Javaid M., Korchina V.,
RA Kovar C., Mata R., Mathew T., Ngo R., Nguyen L., Nguyen N., Okwuonu G.,
RA Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W., Jakkamsetti A.,
RA Pham P., Ruth R., San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C.,
RA Zhu D., Lee S., Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S.,
RA Hirani K., Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S.,
RA Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L.,
RA Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P.,
RA Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K.,
RA Petrosino J., Highlander S., Gibbs R.;
RL Submitted (JUL-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFM24567.1}.
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DR EMBL; AEEH01000051; EFM24567.1; -; Genomic_DNA.
DR RefSeq; WP_008902578.1; NZ_GL397071.1.
DR AlphaFoldDB; E0NNR4; -.
DR STRING; 862517.HMPREF9225_1803; -.
DR eggNOG; COG0770; Bacteria.
DR HOGENOM; CLU_035297_0_0_9; -.
DR OrthoDB; 9801978at2; -.
DR Proteomes; UP000003280; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0047480; F:UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0008766; F:UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR Gene3D; 3.90.190.20; Mur ligase, C-terminal domain; 1.
DR Gene3D; 3.40.1190.10; Mur-like, catalytic domain; 1.
DR InterPro; IPR036565; Mur-like_cat_sf.
DR InterPro; IPR004101; Mur_ligase_C.
DR InterPro; IPR036615; Mur_ligase_C_dom_sf.
DR InterPro; IPR013221; Mur_ligase_cen.
DR PANTHER; PTHR43024; UDP-N-ACETYLMURAMOYL-TRIPEPTIDE--D-ALANYL-D-ALANINE LIGASE; 1.
DR PANTHER; PTHR43024:SF1; UDP-N-ACETYLMURAMOYL-TRIPEPTIDE--D-ALANYL-D-ALANINE LIGASE; 1.
DR Pfam; PF02875; Mur_ligase_C; 1.
DR Pfam; PF08245; Mur_ligase_M; 1.
DR SUPFAM; SSF53623; MurD-like peptide ligases, catalytic domain; 1.
DR SUPFAM; SSF53244; MurD-like peptide ligases, peptide-binding domain; 1.
PE 4: Predicted;
KW Ligase {ECO:0000313|EMBL:EFM24567.1}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000003280};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..24
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 85..106
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 112..132
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 166..355
FT /note="Mur ligase central"
FT /evidence="ECO:0000259|Pfam:PF08245"
FT DOMAIN 376..456
FT /note="Mur ligase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02875"
SQ SEQUENCE 510 AA; 57733 MW; A8CECF01C4A1A2EE CRC64;
MDKTKLIIEF VVYIVAYIAW RVLITAKAKY HLNIIQLNEY DNDKYRDWIK NNFSKAYSPF
NEKTDSKTPL VMTDRAKRLL ATYLNIYRGL VTVVILAILC FTNYRISIYA GIIFLLIALF
MQPQMMIVAN AINLPKEKKI NMGFYTSAQE KIRRLKAESG LKVIGITGSF GKTSVKFFTS
TMLDEKFRVQ NTPSSYNTPM GLSKVINNEL DSSREIFLAE LGAYKPGEIH EVASLVQPDI
GVITAIGPTH MQMYKTIENI MKTKYELIED LDENGTAIFN YDNKYVRELA DKTTKKTIRY
GTKDFMKLDY YAKDIEVSER GSTFTLVSKE KGSIECTTKL LGEHSVQNLL ASVAIGMELG
MSLEEVKDRI EKIESVEHRL NLIEGQGGVI VIDDAFNSNP VGFRAALKVL SQFKDGKKII
VTPGMVELGE MEEEENYKVG KEIAKVCDYA ILVGIKRTEP IRRGLLDSKF DEGRIISVRS
LNDATSELGK ITAPRDVVLF ENDLPDSYEE
//
