ID E0PD50_STREI Unreviewed; 281 AA.
AC E0PD50;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=Oxidoreductase, aldo/keto reductase family protein {ECO:0000313|EMBL:EFM27635.1};
DE EC=1.1.1.218 {ECO:0000313|EMBL:EFM27635.1};
GN Name=akr5f {ECO:0000313|EMBL:EFM27635.1};
GN ORFNames=HMPREF9319_0773 {ECO:0000313|EMBL:EFM27635.1};
OS Streptococcus equinus ATCC 700338.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=864569 {ECO:0000313|EMBL:EFM27635.1, ECO:0000313|Proteomes:UP000004290};
RN [1] {ECO:0000313|EMBL:EFM27635.1, ECO:0000313|Proteomes:UP000004290}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700338 {ECO:0000313|EMBL:EFM27635.1,
RC ECO:0000313|Proteomes:UP000004290};
RA Muzny D., Qin X., Deng J., Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L.,
RA Thornton R., Coyle M., Francisco L., Jackson L., Javaid M., Korchina V.,
RA Kovar C., Mata R., Mathew T., Ngo R., Nguyen L., Nguyen N., Okwuonu G.,
RA Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W., Jakkamsetti A.,
RA Pham P., Ruth R., San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C.,
RA Zhu D., Lee S., Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S.,
RA Hirani K., Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S.,
RA Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L.,
RA Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P.,
RA Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K.,
RA Petrosino J., Highlander S., Gibbs R.;
RL Submitted (JUL-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFM27635.1}.
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DR EMBL; AEEL01000013; EFM27635.1; -; Genomic_DNA.
DR RefSeq; WP_003064412.1; NZ_GL397128.1.
DR AlphaFoldDB; E0PD50; -.
DR GeneID; 64018640; -.
DR HOGENOM; CLU_023205_0_1_9; -.
DR Proteomes; UP000004290; Miscellaneous, Scaffold Scaffold1.
DR GO; GO:0050109; F:morphine 6-dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0071704; P:organic substance metabolic process; IEA:UniProt.
DR GO; GO:0044281; P:small molecule metabolic process; IEA:UniProt.
DR CDD; cd19133; AKR_AKR5F1; 1.
DR Gene3D; 3.20.20.100; NADP-dependent oxidoreductase domain; 1.
DR InterPro; IPR020471; AKR.
DR InterPro; IPR018170; Aldo/ket_reductase_CS.
DR InterPro; IPR023210; NADP_OxRdtase_dom.
DR InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR PANTHER; PTHR43827; 2,5-DIKETO-D-GLUCONIC ACID REDUCTASE; 1.
DR PANTHER; PTHR43827:SF3; ALDO-KETO REDUCTASE; 1.
DR Pfam; PF00248; Aldo_ket_red; 1.
DR PIRSF; PIRSF000097; AKR; 2.
DR PRINTS; PR00069; ALDKETRDTASE.
DR SUPFAM; SSF51430; NAD(P)-linked oxidoreductase; 1.
DR PROSITE; PS00798; ALDOKETO_REDUCTASE_1; 1.
DR PROSITE; PS00062; ALDOKETO_REDUCTASE_2; 1.
DR PROSITE; PS00063; ALDOKETO_REDUCTASE_3; 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000313|EMBL:EFM27635.1}.
FT DOMAIN 23..257
FT /note="NADP-dependent oxidoreductase"
FT /evidence="ECO:0000259|Pfam:PF00248"
FT ACT_SITE 49
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-1"
FT BINDING 107
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-2"
FT SITE 74
FT /note="Lowers pKa of active site Tyr"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-3"
SQ SEQUENCE 281 AA; 31843 MW; 021321698139A0EC CRC64;
MDYKTLSNGV KMPILGFGVY QVPDLDECER VVSDAISIGY RSIDTAQAYM NEEAVGNAIR
KSGNAREEFF ITTKIWISNY GYEKAKASLD ASLAKLQTDY IDLVLLHQPF GDYYGAYRAM
EEYYKAGKIK AIGISNFAPD RVADLAIFAD VTPMVNQVET HVFNQQSNAR KTMDEYGVQI
ESWGPFAEGR NDFFTNETLV AIGQKYQKSA AQVALRYLIQ RDVIVIPKTV HKNRMEQNFD
VFDFILTDDD MAEILKLDMG ESQFFSHADP ETVKMISSFK I
//
