ID E0PSP9_STRMT Unreviewed; 364 AA.
AC E0PSP9;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=Cystathionine gamma-synthase {ECO:0000313|EMBL:EFM30935.1};
DE EC=2.5.1.48 {ECO:0000313|EMBL:EFM30935.1};
GN Name=metC {ECO:0000313|EMBL:EFM30935.1};
GN ORFNames=HMPREF8571_1374 {ECO:0000313|EMBL:EFM30935.1};
OS Streptococcus mitis ATCC 6249.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=864567 {ECO:0000313|EMBL:EFM30935.1, ECO:0000313|Proteomes:UP000003823};
RN [1] {ECO:0000313|EMBL:EFM30935.1, ECO:0000313|Proteomes:UP000003823}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 6249 {ECO:0000313|EMBL:EFM30935.1,
RC ECO:0000313|Proteomes:UP000003823};
RA Muzny D., Qin X., Deng J., Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L.,
RA Thornton R., Coyle M., Francisco L., Jackson L., Javaid M., Korchina V.,
RA Kovar C., Mata R., Mathew T., Ngo R., Nguyen L., Nguyen N., Okwuonu G.,
RA Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W., Jakkamsetti A.,
RA Pham P., Ruth R., San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C.,
RA Zhu D., Lee S., Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S.,
RA Hirani K., Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S.,
RA Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L.,
RA Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P.,
RA Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K.,
RA Petrosino J., Highlander S., Gibbs R.;
RL Submitted (JUL-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933,
CC ECO:0000256|RuleBase:RU362118};
CC -!- SIMILARITY: Belongs to the trans-sulfuration enzymes family.
CC {ECO:0000256|RuleBase:RU362118}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFM30935.1}.
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DR EMBL; AEEN01000015; EFM30935.1; -; Genomic_DNA.
DR RefSeq; WP_000031946.1; NZ_GL397179.1.
DR AlphaFoldDB; E0PSP9; -.
DR GeneID; 49600123; -.
DR eggNOG; COG0626; Bacteria.
DR HOGENOM; CLU_018986_2_1_9; -.
DR OrthoDB; 9780685at2; -.
DR Proteomes; UP000003823; Unassembled WGS sequence.
DR GO; GO:0003962; F:cystathionine gamma-synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0102028; F:cystathionine gamma-synthase activity (acts on O-phosphohomoserine); IEA:UniProtKB-EC.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR GO; GO:0019346; P:transsulfuration; IEA:InterPro.
DR CDD; cd00614; CGS_like; 1.
DR Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR InterPro; IPR000277; Cys/Met-Metab_PyrdxlP-dep_enz.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR PANTHER; PTHR11808:SF91; CYSTATHIONINE GAMMA-SYNTHASE; 1.
DR PANTHER; PTHR11808; TRANS-SULFURATION ENZYME FAMILY MEMBER; 1.
DR Pfam; PF01053; Cys_Met_Meta_PP; 1.
DR PIRSF; PIRSF001434; CGS; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
DR PROSITE; PS00868; CYS_MET_METAB_PP; 1.
PE 3: Inferred from homology;
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898,
KW ECO:0000256|PIRSR:PIRSR001434-2};
KW Transferase {ECO:0000313|EMBL:EFM30935.1}.
FT MOD_RES 197
FT /note="N6-(pyridoxal phosphate)lysine"
FT /evidence="ECO:0000256|PIRSR:PIRSR001434-2"
SQ SEQUENCE 364 AA; 40085 MW; 9526A60D34DDC839 CRC64;
MSKELHINTI LAQAGIKSDE ATGALVTPLH FSTTYQHPEF GQSTGFDYTR TKNPTRSKAE
EVLAAIESAD YALATSSGMA AIVLAFSVFP VGSKVLAVRD LYGGSFRWFN QVEQEGRFHF
TYANTEEELI AELEKDVDVL YIETPTNPLM LEFDIAKLAK LAHAKGAKVV VDNTFYSPIY
QRPIEDGADI VLHSATKYLA GHNDVLAGVV VTNSLELYEQ LFYNLNTTGA VLSPFDSYQL
IRGLKTLPLR MERSTANAQE VVAFLKDSPA VKEVLYTGRG GMISFKVVDE KRIPHILNSL
KVFSFAESLG GVESLITYPT TQTHADIPAE VRHSYGLTDD LLRLSIGIED ARDLIADLRQ
ALEG
//
