ID E0Q127_9STRE Unreviewed; 322 AA.
AC E0Q127;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2010, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE SubName: Full=Dehydrogenase E1 component {ECO:0000313|EMBL:EFM35603.1};
DE EC=1.1.1.- {ECO:0000313|EMBL:EFM35603.1};
GN Name=acoA {ECO:0000313|EMBL:EFM35603.1};
GN ORFNames=HMPREF9189_0758 {ECO:0000313|EMBL:EFM35603.1};
OS Streptococcus sp. oral taxon 071 str. 73H25AP.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=864570 {ECO:0000313|EMBL:EFM35603.1, ECO:0000313|Proteomes:UP000005184};
RN [1] {ECO:0000313|EMBL:EFM35603.1, ECO:0000313|Proteomes:UP000005184}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=73H25AP {ECO:0000313|EMBL:EFM35603.1,
RC ECO:0000313|Proteomes:UP000005184};
RA Muzny D., Qin X., Deng J., Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L.,
RA Thornton R., Coyle M., Francisco L., Jackson L., Javaid M., Korchina V.,
RA Kovar C., Mata R., Mathew T., Ngo R., Nguyen L., Nguyen N., Okwuonu G.,
RA Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W., Jakkamsetti A.,
RA Pham P., Ruth R., San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C.,
RA Zhu D., Lee S., Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S.,
RA Hirani K., Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S.,
RA Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L.,
RA Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P.,
RA Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K.,
RA Petrosino J., Highlander S., Gibbs R.;
RL Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC Evidence={ECO:0000256|ARBA:ARBA00001964};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFM35603.1}.
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DR EMBL; AEEP01000008; EFM35603.1; -; Genomic_DNA.
DR RefSeq; WP_000105343.1; NZ_GL397254.1.
DR AlphaFoldDB; E0Q127; -.
DR eggNOG; COG1071; Bacteria.
DR HOGENOM; CLU_029393_5_0_9; -.
DR Proteomes; UP000005184; Unassembled WGS sequence.
DR GO; GO:0016624; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor; IEA:InterPro.
DR CDD; cd02000; TPP_E1_PDC_ADC_BCADC; 1.
DR Gene3D; 3.40.50.970; -; 1.
DR InterPro; IPR001017; DH_E1.
DR InterPro; IPR029061; THDP-binding.
DR PANTHER; PTHR11516:SF60; PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT ALPHA; 1.
DR PANTHER; PTHR11516; PYRUVATE DEHYDROGENASE E1 COMPONENT, ALPHA SUBUNIT BACTERIAL AND ORGANELLAR; 1.
DR Pfam; PF00676; E1_dh; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:EFM35603.1}.
FT DOMAIN 14..311
FT /note="Dehydrogenase E1 component"
FT /evidence="ECO:0000259|Pfam:PF00676"
FT COILED 279..306
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 322 AA; 35049 MW; 17D90138380A6FE8 CRC64;
MSTLDINLLL EMFRKMEEIR RMDLKIAQLV KKGKVPGMTH FSVGEEAANV GAMLALNPDD
LITSNHRGHG QAIAKGIDLN GMMAEILGKY TGTCKGKGGS MHIADLDAGN LGANGIVGGG
MGIAVGAALS QQMKNTGKIV VCFFGDGATN EGVFHEAVNM ASIWNLPVIF YCINNGYGIS
ADIKKMTNVE HIHQRSAAYG IPGMFIEDGN NVINVYEGFK KAVDHVRGGN GPVLIESITY
RWLGHSSSDP GKYRTREEVE LWKQKDPIEN LRKYLIENNI ASAEELEEIQ AQVKEAVEAS
VKFAEESPFP PLESAFEDIY AD
//
