ID E0QQ28_9ACTO Unreviewed; 526 AA.
AC E0QQ28;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN Name=xamIM {ECO:0000313|EMBL:EFM46408.1};
GN ORFNames=HMPREF0580_0955 {ECO:0000313|EMBL:EFM46408.1};
OS Mobiluncus mulieris ATCC 35239.
OC Bacteria; Actinomycetota; Actinomycetes; Actinomycetales; Actinomycetaceae;
OC Mobiluncus.
OX NCBI_TaxID=871571 {ECO:0000313|EMBL:EFM46408.1, ECO:0000313|Proteomes:UP000003045};
RN [1] {ECO:0000313|EMBL:EFM46408.1, ECO:0000313|Proteomes:UP000003045}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35239 {ECO:0000313|EMBL:EFM46408.1,
RC ECO:0000313|Proteomes:UP000003045};
RA Muzny D., Qin X., Deng J., Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L.,
RA Thornton R., Coyle M., Francisco L., Jackson L., Javaid M., Korchina V.,
RA Kovar C., Mata R., Mathew T., Ngo R., Nguyen L., Nguyen N., Okwuonu G.,
RA Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W., Jakkamsetti A.,
RA Pham P., Ruth R., San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C.,
RA Zhu D., Lee S., Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S.,
RA Hirani K., Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S.,
RA Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L.,
RA Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P.,
RA Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K.,
RA Petrosino J., Highlander S., Gibbs R.;
RL Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
CC -!- SIMILARITY: Belongs to the N(4)/N(6)-methyltransferase family.
CC {ECO:0000256|ARBA:ARBA00006594}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFM46408.1}.
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DR EMBL; AEET01000024; EFM46408.1; -; Genomic_DNA.
DR RefSeq; WP_004011862.1; NZ_GL405260.1.
DR AlphaFoldDB; E0QQ28; -.
DR STRING; 871571.HMPREF0580_0955; -.
DR REBASE; 415684; M.Mmu35239ORF955P.
DR GeneID; 66607228; -.
DR HOGENOM; CLU_034179_0_0_11; -.
DR Proteomes; UP000003045; Unassembled WGS sequence.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR011639; MethylTrfase_TaqI-like_dom.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR33841:SF1; ADENINE-SPECIFIC METHYLTRANSFERASE PGLX; 1.
DR PANTHER; PTHR33841; DNA METHYLTRANSFERASE YEEA-RELATED; 1.
DR Pfam; PF07669; Eco57I; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:EFM46408.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000003045};
KW Restriction system {ECO:0000256|ARBA:ARBA00022747};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:EFM46408.1}.
FT DOMAIN 121..216
FT /note="Type II methyltransferase M.TaqI-like"
FT /evidence="ECO:0000259|Pfam:PF07669"
SQ SEQUENCE 526 AA; 58874 MW; D4D33201C2F308BD CRC64;
MSNTTGEVFT RRWVVEFMLD LAGYVGDVSR LRVIEPSIGA GAFAMPIVER IAKLHPDWNT
LHGALRGYDI NPDHVDTCKA AARTVLDAAG CPISDTLVNS WFQVKDFLLT GDLTASNSAQ
ADLVIGNPPY IRMENLNSSL LHSYRNVCST MKGRADIFVG FFERGLDALR PGGRLIYICA
DRWMRNSYGK DLRAKIAADF SVDDVLVMHE ADAFEEKVSA YPAIVNIRKG CQGKVNVATA
NPSFASAGAR RFLEWQRTSA EAYQDDDFSG ARMEHWHSTS AVWPDGSPAV LQWLSKLENM
PVIEENAVHI GIGIATGADQ IYIQKHADVE DDRLVPMVTP RAIKGAKFSW TGEHLVSPWQ
GRNLVDLERY PKLKHYYSSN YQRLSARNVA KRSNYWWRTI DSFNPALMER DLIVMQDMKL
HAHPVRVPTG FYPHHGLTWF ASDVWDLGVL GGLLLSEPIE KQVAAHCVRM RGGTLRFQPT
VMRTVRLPLL STIPADIASE LSQAFATHDR ARADAAAWQL YPQMES
//
