ID E0QSZ0_9ACTO Unreviewed; 482 AA.
AC E0QSZ0;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2010, sequence version 1.
DT 24-JAN-2024, entry version 57.
DE RecName: Full=Signal peptidase I {ECO:0000256|ARBA:ARBA00013208, ECO:0000256|RuleBase:RU362042};
DE EC=3.4.21.89 {ECO:0000256|ARBA:ARBA00013208, ECO:0000256|RuleBase:RU362042};
GN Name=lepB {ECO:0000313|EMBL:EFM45329.1};
GN ORFNames=HMPREF0580_2018 {ECO:0000313|EMBL:EFM45329.1};
OS Mobiluncus mulieris ATCC 35239.
OC Bacteria; Actinomycetota; Actinomycetes; Actinomycetales; Actinomycetaceae;
OC Mobiluncus.
OX NCBI_TaxID=871571 {ECO:0000313|EMBL:EFM45329.1, ECO:0000313|Proteomes:UP000003045};
RN [1] {ECO:0000313|EMBL:EFM45329.1, ECO:0000313|Proteomes:UP000003045}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35239 {ECO:0000313|EMBL:EFM45329.1,
RC ECO:0000313|Proteomes:UP000003045};
RA Muzny D., Qin X., Deng J., Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L.,
RA Thornton R., Coyle M., Francisco L., Jackson L., Javaid M., Korchina V.,
RA Kovar C., Mata R., Mathew T., Ngo R., Nguyen L., Nguyen N., Okwuonu G.,
RA Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W., Jakkamsetti A.,
RA Pham P., Ruth R., San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C.,
RA Zhu D., Lee S., Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S.,
RA Hirani K., Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S.,
RA Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L.,
RA Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P.,
RA Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K.,
RA Petrosino J., Highlander S., Gibbs R.;
RL Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Cleavage of hydrophobic, N-terminal signal or leader sequences
CC from secreted and periplasmic proteins.; EC=3.4.21.89;
CC Evidence={ECO:0000256|ARBA:ARBA00000677,
CC ECO:0000256|RuleBase:RU362042};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU362042}; Single-
CC pass type II membrane protein {ECO:0000256|RuleBase:RU362042}.
CC -!- SIMILARITY: Belongs to the peptidase S26 family.
CC {ECO:0000256|ARBA:ARBA00009370, ECO:0000256|RuleBase:RU362042}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFM45329.1}.
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DR EMBL; AEET01000044; EFM45329.1; -; Genomic_DNA.
DR RefSeq; WP_004012905.1; NZ_GL405260.1.
DR AlphaFoldDB; E0QSZ0; -.
DR STRING; 871571.HMPREF0580_2018; -.
DR GeneID; 66608171; -.
DR HOGENOM; CLU_565980_0_0_11; -.
DR Proteomes; UP000003045; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-EC.
DR GO; GO:0006465; P:signal peptide processing; IEA:InterPro.
DR CDD; cd06530; S26_SPase_I; 1.
DR Gene3D; 2.10.109.10; Umud Fragment, subunit A; 1.
DR InterPro; IPR036286; LexA/Signal_pep-like_sf.
DR InterPro; IPR000223; Pept_S26A_signal_pept_1.
DR InterPro; IPR019758; Pept_S26A_signal_pept_1_CS.
DR InterPro; IPR019533; Peptidase_S26.
DR NCBIfam; TIGR02227; sigpep_I_bact; 1.
DR PANTHER; PTHR43390:SF1; CHLOROPLAST PROCESSING PEPTIDASE; 1.
DR PANTHER; PTHR43390; SIGNAL PEPTIDASE I; 1.
DR Pfam; PF10502; Peptidase_S26; 1.
DR PRINTS; PR00727; LEADERPTASE.
DR SUPFAM; SSF51306; LexA/Signal peptidase; 1.
DR PROSITE; PS00761; SPASE_I_3; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|RuleBase:RU362042, ECO:0000313|EMBL:EFM45329.1};
KW Protease {ECO:0000256|RuleBase:RU362042};
KW Reference proteome {ECO:0000313|Proteomes:UP000003045}.
FT DOMAIN 244..441
FT /note="Peptidase S26"
FT /evidence="ECO:0000259|Pfam:PF10502"
FT REGION 1..89
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 138..180
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 25..50
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 145..159
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 273
FT /evidence="ECO:0000256|PIRSR:PIRSR600223-1"
FT ACT_SITE 351
FT /evidence="ECO:0000256|PIRSR:PIRSR600223-1"
SQ SEQUENCE 482 AA; 52378 MW; AA231CD602A01F96 CRC64;
MDVSPKFSAD NGGTFPPGTG LPPDPRSDKQ SSGSTKGAAN SGTEGHNGRN LNPKGTGGAR
GVDSSETQYF AEEFPRAHPG GEFPGGMTGR MPGAMPGEYP GYPPMYSAWN PDLGFGDYPP
GLYDQLFEYY SNGAHPYSGR SDGKKTGSDA SHPEKGARSK VTQRAGSGKG ESKNPDNDDD
LLWGDLNDFQ AVHQSDSNRD SVDEFRASRM MRPRAYPNPN ELMVRQAGAF GRPQLTLDFP
WYFELIAVVI TMLTISSLVR TFLLQPFYIP SASMQNTLMV NDSVLVAKTA PRYSPLNRGD
IVVFRDTENW LQSGREGLVK KKAPNPVLGG IKRFMIFAGL APEDAQGFVI KRVMGMGGDT
VTCCDEDGLL NINGKAIDED YTLNTGVASE VKFNVVVPKG SLWVMGDNRN HSADSRYHMD
SPSGGFVSEK QVVGRAFVVV WPLEHMRFIS PSCAFYNIPK PVLGDKDAFS SESNEVPPGR
RG
//
