ID   E0RWQ8_BUTPB            Unreviewed;       848 AA.
AC   E0RWQ8;
DT   02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2010, sequence version 1.
DT   27-MAR-2024, entry version 59.
DE   SubName: Full=GGDEF/EAL domain-containing protein {ECO:0000313|EMBL:ADL34584.1};
GN   OrderedLocusNames=bpr_I1850 {ECO:0000313|EMBL:ADL34584.1};
OS   Butyrivibrio proteoclasticus (strain ATCC 51982 / DSM 14932 / B316)
OS   (Clostridium proteoclasticum).
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae;
OC   Butyrivibrio.
OX   NCBI_TaxID=515622 {ECO:0000313|EMBL:ADL34584.1, ECO:0000313|Proteomes:UP000001299};
RN   [1] {ECO:0000313|EMBL:ADL34584.1, ECO:0000313|Proteomes:UP000001299}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51982 / DSM 14932 / B316
RC   {ECO:0000313|Proteomes:UP000001299};
RX   PubMed=20689770; DOI=10.1371/journal.pone.0011942;
RA   Kelly W.J., Leahy S.C., Altermann E., Yeoman C.J., Dunne J.C., Kong Z.,
RA   Pacheco D.M., Li D., Noel S.J., Moon C.D., Cookson A.L., Attwood G.T.;
RT   "The glycobiome of the rumen bacterium Butyrivibrio proteoclasticus B316(T)
RT   highlights adaptation to a polysaccharide-rich environment.";
RL   PLoS ONE 5:E11942-E11942(2010).
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DR   EMBL; CP001810; ADL34584.1; -; Genomic_DNA.
DR   AlphaFoldDB; E0RWQ8; -.
DR   STRING; 515622.bpr_I1850; -.
DR   KEGG; bpb:bpr_I1850; -.
DR   eggNOG; COG2984; Bacteria.
DR   eggNOG; COG5001; Bacteria.
DR   HOGENOM; CLU_000445_49_3_9; -.
DR   Proteomes; UP000001299; Chromosome 1.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   CDD; cd01948; EAL; 1.
DR   CDD; cd01949; GGDEF; 1.
DR   Gene3D; 3.30.70.270; -; 1.
DR   Gene3D; 3.40.50.2300; -; 2.
DR   Gene3D; 3.20.20.450; EAL domain; 1.
DR   InterPro; IPR001633; EAL_dom.
DR   InterPro; IPR035919; EAL_sf.
DR   InterPro; IPR000160; GGDEF_dom.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   NCBIfam; TIGR00254; GGDEF; 1.
DR   PANTHER; PTHR33121; CYCLIC DI-GMP PHOSPHODIESTERASE PDEF; 1.
DR   PANTHER; PTHR33121:SF84; SIGNALLING PROTEIN WITH EAL DOMAIN; 1.
DR   Pfam; PF00563; EAL; 1.
DR   Pfam; PF00990; GGDEF; 1.
DR   SMART; SM00052; EAL; 1.
DR   SMART; SM00267; GGDEF; 1.
DR   SUPFAM; SSF141868; EAL domain-like; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   PROSITE; PS50883; EAL; 1.
DR   PROSITE; PS50887; GGDEF; 1.
PE   4: Predicted;
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001299};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        12..35
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          444..576
FT                   /note="GGDEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50887"
FT   DOMAIN          585..835
FT                   /note="EAL"
FT                   /evidence="ECO:0000259|PROSITE:PS50883"
SQ   SEQUENCE   848 AA;  97337 MW;  3BDE3328E4BB97E3 CRC64;
     MQERKRQIFL YMRYALTAIG ILLLIAAIIT LVLSIRSDNQ SNDVRRPTEV NHRVLFLCAY
     NSLYFTYDDQ VEGLKQALYP HGIEFDVVYM DTKSYGTPND KLVFYEFFKD RLRKAPEYEA
     ILLGDDDALE FALTYQEELF EGIPMVFFGI NDIDFAVEAA QNPMATGFYE KDYLRDCMEI
     AMKAMPDRKT LVALHDESAA GAADMDIFFS YDQKYPDYVF RDIDTAEFTQ AELIGLLRNL
     PEDSILFYMT CYNDRYGNTY SMLNRTNTVV MNAKVPIIRN YSGGRNQGVL GGVYMDFIAQ
     TRDAGQIVVD ILENGTDISE YPLDLETPSK SEFNYELMQK YGVDESVLPA NTSYVNKPIS
     PFEYYKKIIP ASVLIVSALL MLIISANMTA NLQKNANEQL KTFADNLKNT GSKLKYQADH
     DELSDLLNRR AIVETLGRIL QKDEKYAIMM IDIDGFKVIN ENYGHVMADQ IIKHLAKELK
     NLAEEQKWQV GRYGGDEFIV MVPDVKLDVD SKEVRQILEI FREPIVAGEE TLALSASVGV
     SNSDGASNPE QHIINAEIAM YEAKEHGKNT AFVYADEMQR KIQEENRLKA LVTEAFDENL
     FYMVYQPKIE TATGKTIGFE ALVRARNIQS GPSTFIPIIE KNGWVIRLGR MVTEQVIRQM
     ALWRDQGKEL IPISINFSSK QVNDLGFMNF IKMLMDQYDI SHKFIQIEIT ESLLIEQNIQ
     TQKLFDEFKD MGFRILMDDF GTGYSSLGYL IYIPIDEIKL DKSLVDAYLV PGKDNFIGDV
     IKLVHDINKT IIIEGVEEKW QYERLREFKA DAVQGYYFSK PLEADEAIKF MAQSEERKCR
     NEKMDFLK
//