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Database: UniProt
Entry: E0T2N0
LinkDB: E0T2N0
Original site: E0T2N0 
ID   MDFA_EDWTF              Reviewed;         410 AA.
AC   E0T2N0;
DT   08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
DT   08-MAR-2011, sequence version 2.
DT   01-OCT-2014, entry version 17.
DE   RecName: Full=Multidrug transporter MdfA;
GN   Name=mdfA; OrderedLocusNames=ETAF_3150;
OS   Edwardsiella tarda (strain FL6-60).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Edwardsiella.
OX   NCBI_TaxID=718251;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FL6-60;
RA   van Soest J.J., Henkel C.V., Jansen H.J., van den Hondel C.A.M.J.J.,
RA   Bloemberg G.V., Meijer A.H., Spaink H.P.;
RT   "Genome comparisons of Edwardsiella bacteria analysed using deep
RT   sequencing technology.";
RL   Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Efflux pump driven by the proton motive force. Confers
CC       resistance to a broad spectrum of chemically unrelated drugs (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Monomer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-
CC       pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. MdfA
CC       family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ADM43253.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
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DR   EMBL; CP002154; ADM43253.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; YP_005700745.1; NC_017309.1.
DR   EnsemblBacteria; ADM43253; ADM43253; ETAF_3150.
DR   GeneID; 12860466; -.
DR   KEGG; etd:ETAF_3150; -.
DR   PATRIC; 42921180; VBIEdwTar147555_3283.
DR   HOGENOM; HOG000118215; -.
DR   KO; K08160; -.
DR   OMA; ATHWVQS; -.
DR   BioCyc; ETAR718251:GLCN-3257-MONOMER; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005215; F:transporter activity; IEA:InterPro.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR016196; MFS_dom_general_subst_transpt.
DR   InterPro; IPR005829; Sugar_transporter_CS.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   3: Inferred from homology;
KW   Antibiotic resistance; Cell inner membrane; Cell membrane;
KW   Complete proteome; Membrane; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN         1    410       Multidrug transporter MdfA.
FT                                /FTId=PRO_0000405337.
FT   TOPO_DOM      1     15       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM     16     36       Helical. {ECO:0000255}.
FT   TOPO_DOM     37     52       Periplasmic. {ECO:0000255}.
FT   TRANSMEM     53     73       Helical. {ECO:0000255}.
FT   TOPO_DOM     74     84       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM     85    105       Helical. {ECO:0000255}.
FT   TOPO_DOM    106    109       Periplasmic. {ECO:0000255}.
FT   TRANSMEM    110    130       Helical. {ECO:0000255}.
FT   TOPO_DOM    131    144       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM    145    165       Helical. {ECO:0000255}.
FT   TOPO_DOM    166    166       Periplasmic. {ECO:0000255}.
FT   TRANSMEM    167    187       Helical. {ECO:0000255}.
FT   TOPO_DOM    188    226       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM    227    247       Helical. {ECO:0000255}.
FT   TOPO_DOM    248    255       Periplasmic. {ECO:0000255}.
FT   TRANSMEM    256    276       Helical. {ECO:0000255}.
FT   TOPO_DOM    277    286       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM    287    307       Helical. {ECO:0000255}.
FT   TOPO_DOM    308    313       Periplasmic. {ECO:0000255}.
FT   TRANSMEM    314    334       Helical. {ECO:0000255}.
FT   TOPO_DOM    335    346       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM    347    367       Helical. {ECO:0000255}.
FT   TOPO_DOM    368    378       Periplasmic. {ECO:0000255}.
FT   TRANSMEM    379    399       Helical. {ECO:0000255}.
FT   TOPO_DOM    400    410       Cytoplasmic. {ECO:0000255}.
SQ   SEQUENCE   410 AA;  44390 MW;  745FA29FD6B11591 CRC64;
     MQNRLSSTRR LGRRALLFPL CLVLYEFATY IGNDMIQPGM LSVVQTFGVD ESWVPTSMTA
     YLAGGMFLQW LLGPISDRIG RRPVMLTGTL YFAVTCLAIL LTNSIEQFTL MRFLQGISLC
     FIGAVGYAAI QESFEESVCI KITALMANVA LIAPLLGPLA GAAWVHLFPW EGMFILFAAL
     SLLAFLGLYK AMPETATRRG ETLSLSALGH DYALVLKNKR FLGGALACGF ASLPLLAWIA
     QSPVIIISGE GLSSYDYGML QVPIFGMLIL GNFTLARLSG RRPVRRLIQL GAWPMVGGLA
     IAAVSTLYSA HAYLWMTAGL SLYAFGIGLA NAGLYRLTLF SSTMSKGTVS AAMGMISMFI
     YTLGIEVGKH AWLLGGNGAF NLFNLISGLL WLALVALMLR DKRVGGTTER
//
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