ID MDFA_EDWTF Reviewed; 410 AA.
AC E0T2N0;
DT 08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
DT 08-MAR-2011, sequence version 2.
DT 01-MAY-2013, entry version 12.
DE RecName: Full=Multidrug transporter MdfA;
GN Name=mdfA; OrderedLocusNames=ETAF_3150;
OS Edwardsiella tarda (strain FL6-60).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC Enterobacteriaceae; Edwardsiella.
OX NCBI_TaxID=718251;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FL6-60;
RA van Soest J.J., Henkel C.V., Jansen H.J., van den Hondel C.A.M.J.J.,
RA Bloemberg G.V., Meijer A.H., Spaink H.P.;
RT "Genome comparisons of Edwardsiella bacteria analysed using deep
RT sequencing technology.";
RL Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Efflux pump driven by the proton motive force. Confers
CC resistance to a broad spectrum of chemically unrelated drugs (By
CC similarity).
CC -!- SUBUNIT: Monomer (By similarity).
CC -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane
CC protein (By similarity).
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. MdfA
CC family.
CC -!- SEQUENCE CAUTION:
CC Sequence=ADM43253.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
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DR EMBL; CP002154; ADM43253.1; ALT_INIT; Genomic_DNA.
DR RefSeq; YP_005700745.1; NC_017309.1.
DR EnsemblBacteria; ADM43253; ADM43253; ETAF_3150.
DR GeneID; 12860466; -.
DR KEGG; etd:ETAF_3150; -.
DR PATRIC; 42921180; VBIEdwTar147555_3283.
DR HOGENOM; HOG000118215; -.
DR KO; K08160; -.
DR OMA; MLTGVVW; -.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005215; F:transporter activity; IEA:InterPro.
DR GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR016196; MFS_dom_general_subst_transpt.
DR InterPro; IPR005829; Sugar_transporter_CS.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; MFS_gen_substrate_transporter; 1.
DR PROSITE; PS50850; MFS; 1.
PE 3: Inferred from homology;
KW Antibiotic resistance; Cell inner membrane; Cell membrane;
KW Complete proteome; Membrane; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1 410 Multidrug transporter MdfA.
FT /FTId=PRO_0000405337.
FT TOPO_DOM 1 15 Cytoplasmic (Potential).
FT TRANSMEM 16 36 Helical; (Potential).
FT TOPO_DOM 37 52 Periplasmic (Potential).
FT TRANSMEM 53 73 Helical; (Potential).
FT TOPO_DOM 74 84 Cytoplasmic (Potential).
FT TRANSMEM 85 105 Helical; (Potential).
FT TOPO_DOM 106 109 Periplasmic (Potential).
FT TRANSMEM 110 130 Helical; (Potential).
FT TOPO_DOM 131 144 Cytoplasmic (Potential).
FT TRANSMEM 145 165 Helical; (Potential).
FT TOPO_DOM 166 166 Periplasmic (Potential).
FT TRANSMEM 167 187 Helical; (Potential).
FT TOPO_DOM 188 226 Cytoplasmic (Potential).
FT TRANSMEM 227 247 Helical; (Potential).
FT TOPO_DOM 248 255 Periplasmic (Potential).
FT TRANSMEM 256 276 Helical; (Potential).
FT TOPO_DOM 277 286 Cytoplasmic (Potential).
FT TRANSMEM 287 307 Helical; (Potential).
FT TOPO_DOM 308 313 Periplasmic (Potential).
FT TRANSMEM 314 334 Helical; (Potential).
FT TOPO_DOM 335 346 Cytoplasmic (Potential).
FT TRANSMEM 347 367 Helical; (Potential).
FT TOPO_DOM 368 378 Periplasmic (Potential).
FT TRANSMEM 379 399 Helical; (Potential).
FT TOPO_DOM 400 410 Cytoplasmic (Potential).
SQ SEQUENCE 410 AA; 44390 MW; 745FA29FD6B11591 CRC64;
MQNRLSSTRR LGRRALLFPL CLVLYEFATY IGNDMIQPGM LSVVQTFGVD ESWVPTSMTA
YLAGGMFLQW LLGPISDRIG RRPVMLTGTL YFAVTCLAIL LTNSIEQFTL MRFLQGISLC
FIGAVGYAAI QESFEESVCI KITALMANVA LIAPLLGPLA GAAWVHLFPW EGMFILFAAL
SLLAFLGLYK AMPETATRRG ETLSLSALGH DYALVLKNKR FLGGALACGF ASLPLLAWIA
QSPVIIISGE GLSSYDYGML QVPIFGMLIL GNFTLARLSG RRPVRRLIQL GAWPMVGGLA
IAAVSTLYSA HAYLWMTAGL SLYAFGIGLA NAGLYRLTLF SSTMSKGTVS AAMGMISMFI
YTLGIEVGKH AWLLGGNGAF NLFNLISGLL WLALVALMLR DKRVGGTTER
//
