ID E0V8B8_MICOH Unreviewed; 420 AA.
AC E0V8B8;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2010, sequence version 1.
DT 08-NOV-2023, entry version 34.
DE RecName: Full=Vasopressin V1a receptor {ECO:0000256|ARBA:ARBA00021173, ECO:0000256|RuleBase:RU046427};
GN Name=AVPR1A {ECO:0000313|EMBL:ADN07516.1};
OS Microtus ochrogaster (Prairie vole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Arvicolinae; Microtus.
OX NCBI_TaxID=79684 {ECO:0000313|EMBL:ADN07516.1};
RN [1] {ECO:0000313|EMBL:ADN07516.1}
RP NUCLEOTIDE SEQUENCE.
RA Benjamin B., Blakesley R.W., Bouffard G.G., Brooks S., Chodroff R., Chu G.,
RA Chub I., Coleman H., Fuksenko T., Gestole M., Gregory M., Guan X.,
RA Gupta J., Gurson N., Han J., Hansen N., Hargrove A., Hines-Harris K.,
RA Ho S.-L., Hu P., Hurle B., Idol J.R., Johnson T., Kwong P., Lee-Lin S.-Q.,
RA Legaspi R., Lovett S., Madden M., Maduro Q.L., Maduro V.B., Margulies E.H.,
RA Masiello C., Maskeri B., McDowell J., Montemayor C., Mullikin J.C.,
RA Myrick J., Palumbo A., Park M., Prasad A., Ramsahoye C., Reddix-Dugue N.,
RA Riebow N., Schandler K., Schmidt B., Schueler M.G., Sison C., Smith L.,
RA Stantripop S., Thomas J.W., Thomas P.J., Tsipouri V., Young A., Green E.D.;
RT "NISC Comparative Sequencing Initiative.";
RL Submitted (SEP-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Receptor for arginine vasopressin. The activity of this
CC receptor is mediated by G proteins which activate a phosphatidyl-
CC inositol-calcium second messenger system.
CC {ECO:0000256|RuleBase:RU046427}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651,
CC ECO:0000256|RuleBase:RU046427}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU046427}.
CC Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC Vasopressin/oxytocin receptor subfamily.
CC {ECO:0000256|RuleBase:RU046427}.
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DR EMBL; DP001225; ADN07516.1; -; Genomic_DNA.
DR AlphaFoldDB; E0V8B8; -.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005000; F:vasopressin receptor activity; IEA:UniProtKB-UniRule.
DR CDD; cd15385; 7tmA_V1aR; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR015076; V1R_C.
DR InterPro; IPR001817; Vasoprsn_rcpt.
DR InterPro; IPR001224; Vprs_V1A_rcpt.
DR PANTHER; PTHR24241; NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR; 1.
DR PANTHER; PTHR24241:SF17; VASOPRESSIN V1A RECEPTOR; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR Pfam; PF08983; V1R_C; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00896; VASOPRESSINR.
DR PRINTS; PR00752; VASOPRSNV1AR.
DR SMART; SM01164; DUF1856; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW G-protein coupled receptor {ECO:0000256|RuleBase:RU046427};
KW Glycoprotein {ECO:0000256|RuleBase:RU046427};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU046427};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU046427};
KW Transducer {ECO:0000256|RuleBase:RU046427};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU046427};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU046427}.
FT TRANSMEM 55..76
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU046427"
FT TRANSMEM 88..106
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU046427"
FT TRANSMEM 126..148
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU046427"
FT TRANSMEM 169..189
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU046427"
FT TRANSMEM 221..246
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU046427"
FT TRANSMEM 294..312
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU046427"
FT TRANSMEM 332..353
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU046427"
FT DOMAIN 68..350
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 379..411
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 385..411
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 420 AA; 47551 MW; 8043F5F8051E3DFE CRC64;
MSFPRGSYDP AASNSSPWWP LSAEDANSSW EAAGHQKGSD PSGDVRNEEL AKLEIAVLAV
IFVVAVLGNS SVLLALHRTP RKTSRMHLFI RHLSLADLAV AFFQVLPQLC WDITYRFRGP
DWLCRVVKHL QVFAMFASAY MLVVMTADRY IAVCHPLKTL QQPTRRSRLM IAASWVLSFL
LSTPQYFIFS MIEIEVNNGT KTQDCWATFI QPWGTRAYVT WMTSGVFVVP VVILGTCYGF
ICYHIWRNVR GKTASRQSKG SGEDVAPFHK GLLVTPCVSS VKTISRAKIR TVKMTFVIVT
AYILCWAPFF IVQMWSVWDD NFIWTDSENP SITITALLAS LNSCCNPWIY MFFSGHLLQD
CVQSFPCCQR MVQKFTKDDS DNMSRRQTSY SNNRSPTNST GTWKDSPKSS RSIRFIPVST
//
