ID E0V9Y3_PEDHC Unreviewed; 841 AA.
AC E0V9Y3;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE RecName: Full=leucine--tRNA ligase {ECO:0000256|ARBA:ARBA00013164};
DE EC=6.1.1.4 {ECO:0000256|ARBA:ARBA00013164};
DE AltName: Full=Leucyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00030520};
GN Name=8233889 {ECO:0000313|EnsemblMetazoa:PHUM024070-PA};
GN ORFNames=Phum_PHUM024070 {ECO:0000313|EMBL:EEB10189.1};
OS Pediculus humanus subsp. corporis (Body louse).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Paraneoptera; Psocodea; Phthiraptera; Anoplura; Pediculidae;
OC Pediculus.
OX NCBI_TaxID=121224;
RN [1] {ECO:0000313|EMBL:EEB10189.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB10189.1};
RA Kirkness E., Hannick L., Hass B., Bruggner R., Lawson D., Bidwell S.,
RA Joardar V., Caler E., Walenz B., Inman J., Schobel S., Galinsky K.,
RA Amedeo P., Strausberg R.;
RT "Annotation of Pediculus humanus corporis strain USDA.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EEB10189.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB10189.1};
RG The Human Body Louse Genome Consortium;
RA Kirkness E., Walenz B., Hass B., Bruggner R., Strausberg R.;
RT "The genome of the human body louse.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:PHUM024070-PA}
RP IDENTIFICATION.
RC STRAIN=USDA {ECO:0000313|EnsemblMetazoa:PHUM024070-PA};
RG EnsemblMetazoa;
RL Submitted (FEB-2021) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-
CC tRNA(Leu); Xref=Rhea:RHEA:11688, Rhea:RHEA-COMP:9613, Rhea:RHEA-
CC COMP:9622, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57427,
CC ChEBI:CHEBI:78442, ChEBI:CHEBI:78494, ChEBI:CHEBI:456215; EC=6.1.1.4;
CC Evidence={ECO:0000256|ARBA:ARBA00001372};
CC -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family.
CC {ECO:0000256|ARBA:ARBA00005594, ECO:0000256|RuleBase:RU363035}.
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DR EMBL; AAZO01000288; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS235000; EEB10189.1; -; Genomic_DNA.
DR RefSeq; XP_002422927.1; XM_002422882.1.
DR AlphaFoldDB; E0V9Y3; -.
DR STRING; 121224.E0V9Y3; -.
DR EnsemblMetazoa; PHUM024070-RA; PHUM024070-PA; PHUM024070.
DR GeneID; 8233889; -.
DR KEGG; phu:Phum_PHUM024070; -.
DR CTD; 8233889; -.
DR VEuPathDB; VectorBase:PHUM024070; -.
DR eggNOG; KOG0435; Eukaryota.
DR HOGENOM; CLU_004427_0_1_1; -.
DR InParanoid; E0V9Y3; -.
DR OMA; TFMVLAP; -.
DR OrthoDB; 2876972at2759; -.
DR Proteomes; UP000009046; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004823; F:leucine-tRNA ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0006429; P:leucyl-tRNA aminoacylation; IEA:InterPro.
DR CDD; cd00812; LeuRS_core; 1.
DR Gene3D; 3.40.50.620; HUPs; 2.
DR InterPro; IPR001412; aa-tRNA-synth_I_CS.
DR InterPro; IPR002300; aa-tRNA-synth_Ia.
DR InterPro; IPR002302; Leu-tRNA-ligase.
DR InterPro; IPR013155; M/V/L/I-tRNA-synth_anticd-bd.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR009080; tRNAsynth_Ia_anticodon-bd.
DR PANTHER; PTHR43740:SF3; LEUCINE--TRNA LIGASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43740; LEUCYL-TRNA SYNTHETASE; 1.
DR Pfam; PF08264; Anticodon_1; 1.
DR Pfam; PF00133; tRNA-synt_1; 3.
DR PRINTS; PR00985; TRNASYNTHLEU.
DR SUPFAM; SSF47323; Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases; 1.
DR SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
DR PROSITE; PS00178; AA_TRNA_LIGASE_I; 1.
PE 3: Inferred from homology;
KW Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146,
KW ECO:0000256|RuleBase:RU363035};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU363035};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000256|RuleBase:RU363035};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU363035};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917,
KW ECO:0000256|RuleBase:RU363035};
KW Reference proteome {ECO:0000313|Proteomes:UP000009046}.
FT DOMAIN 45..234
FT /note="Aminoacyl-tRNA synthetase class Ia"
FT /evidence="ECO:0000259|Pfam:PF00133"
FT DOMAIN 404..561
FT /note="Aminoacyl-tRNA synthetase class Ia"
FT /evidence="ECO:0000259|Pfam:PF00133"
FT DOMAIN 599..639
FT /note="Aminoacyl-tRNA synthetase class Ia"
FT /evidence="ECO:0000259|Pfam:PF00133"
FT DOMAIN 687..833
FT /note="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase
FT anticodon-binding"
FT /evidence="ECO:0000259|Pfam:PF08264"
FT REGION 817..841
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 841 AA; 96807 MW; 45A6A1A375C3FCC1 CRC64;
MMMREEGIRK EEGAVRFSGS GGGGGGGVNL WNEELTNDVR KKIEKHWSCK TLDFSRIDEN
NDKEKFYVLS MFPYPSGSLH MGHVRVYSIS DVLARFFRMR GKNVIHPMGW DAFGLPAENA
AFEKGINPDE WTQQNIANMK SVMEKLCFSF DWSREFATCD SDYYKWTQFL FLKLYERGLV
YRKEAVVNWD PVDLTVLADE QVDANGRSWR SGAIVEKKLL KQWFVKTTSF SQLLYDGLED
PILEDWKEIK PIQRNWIGKL DGTFINFEIV GHVENCREKE ISIWLKRPEY IDRGKFVAVQ
PGSVWTFGVK QEGLLPYRLK NPFTNESLPV YMTSEVKYLK NNDVYLGIPD LSETDKNFAT
SVGIKCCPGL QESASEEELL DLREKICSEA RERGIGGHPA SFKLRDWLIS RQRFWGTPIP
IIYCERCGEQ PVPETDLPVK LPKVKYLKLG TNPLKEDKSW LNVKCPKCGS EGATRETDTM
DTFVDSSWYF LRFLDPDNAQ AGFNVEKIKK MMPVDIYIGG IEHATLHLYF ARFMNHFLYS
VDLVPHPEPF KRLLCQGLVK GKTFRCEKTG KYVRSDSVEL KNKEYVDKKT GNPVVMNWEK
MSKSKYNGVE PSEMIENYGV DALRTVILAE AAPRSSLNWD EKSFRNILMW QSKLWDAVKK
FNDVRSKSAT NPSKDERSEE FKKLDLYLYD SRNFYVKKIT SLLEKTFSVS VAIAKMQGLT
NSLRKADEET MALSENYEKA LATQIIMLAP IAPSFASELW SGFLKAPNRL SKEEGIEWWD
KPLMEQKWPK VDEDYVEKSD GIVVDMLKLS NKTIAAAKEK KNETKKSSKK KLKVSGSTRN
D
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