ID E0VAX6_PEDHC Unreviewed; 410 AA.
AC E0VAX6;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 78.
DE SubName: Full=Dual specificity protein phosphatase, putative {ECO:0000313|EMBL:EEB10532.1, ECO:0000313|EnsemblMetazoa:PHUM046720-PA};
DE EC=3.1.3.16 {ECO:0000313|EMBL:EEB10532.1};
GN Name=8232731 {ECO:0000313|EnsemblMetazoa:PHUM046720-PA};
GN ORFNames=Phum_PHUM046720 {ECO:0000313|EMBL:EEB10532.1};
OS Pediculus humanus subsp. corporis (Body louse).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Paraneoptera; Psocodea; Phthiraptera; Anoplura; Pediculidae;
OC Pediculus.
OX NCBI_TaxID=121224;
RN [1] {ECO:0000313|EMBL:EEB10532.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB10532.1};
RA Kirkness E., Hannick L., Hass B., Bruggner R., Lawson D., Bidwell S.,
RA Joardar V., Caler E., Walenz B., Inman J., Schobel S., Galinsky K.,
RA Amedeo P., Strausberg R.;
RT "Annotation of Pediculus humanus corporis strain USDA.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EEB10532.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB10532.1};
RG The Human Body Louse Genome Consortium;
RA Kirkness E., Walenz B., Hass B., Bruggner R., Strausberg R.;
RT "The genome of the human body louse.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:PHUM046720-PA}
RP IDENTIFICATION.
RC STRAIN=USDA {ECO:0000313|EnsemblMetazoa:PHUM046720-PA};
RG EnsemblMetazoa;
RL Submitted (FEB-2021) to UniProtKB.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC receptor class dual specificity subfamily.
CC {ECO:0000256|ARBA:ARBA00008601}.
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DR EMBL; AAZO01000548; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS235019; EEB10532.1; -; Genomic_DNA.
DR RefSeq; XP_002423270.1; XM_002423225.1.
DR AlphaFoldDB; E0VAX6; -.
DR STRING; 121224.E0VAX6; -.
DR EnsemblMetazoa; PHUM046720-RA; PHUM046720-PA; PHUM046720.
DR GeneID; 8232731; -.
DR KEGG; phu:Phum_PHUM046720; -.
DR CTD; 8232731; -.
DR VEuPathDB; VectorBase:PHUM046720; -.
DR eggNOG; KOG1717; Eukaryota.
DR HOGENOM; CLU_027074_0_0_1; -.
DR InParanoid; E0VAX6; -.
DR OMA; NDQRCIG; -.
DR OrthoDB; 2901840at2759; -.
DR Proteomes; UP000009046; Unassembled WGS sequence.
DR GO; GO:0017017; F:MAP kinase tyrosine/serine/threonine phosphatase activity; IEA:InterPro.
DR GO; GO:0017018; F:myosin phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd01446; DSP_MapKP; 1.
DR CDD; cd14566; DSP_MKP_classII; 1.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR Gene3D; 3.40.250.10; Rhodanese-like domain; 1.
DR InterPro; IPR000340; Dual-sp_phosphatase_cat-dom.
DR InterPro; IPR008343; MKP.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR001763; Rhodanese-like_dom.
DR InterPro; IPR036873; Rhodanese-like_dom_sf.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR InterPro; IPR020422; TYR_PHOSPHATASE_DUAL_dom.
DR PANTHER; PTHR10159; DUAL SPECIFICITY PROTEIN PHOSPHATASE; 1.
DR PANTHER; PTHR10159:SF519; DUAL SPECIFICITY PROTEIN PHOSPHATASE MPK3; 1.
DR Pfam; PF00782; DSPc; 1.
DR Pfam; PF00581; Rhodanese; 1.
DR PRINTS; PR01764; MAPKPHPHTASE.
DR SMART; SM00195; DSPc; 1.
DR SMART; SM00450; RHOD; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF52821; Rhodanese/Cell cycle control phosphatase; 1.
DR PROSITE; PS50206; RHODANESE_3; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50054; TYR_PHOSPHATASE_DUAL; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000313|EMBL:EEB10532.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000009046}.
FT DOMAIN 29..147
FT /note="Rhodanese"
FT /evidence="ECO:0000259|PROSITE:PS50206"
FT DOMAIN 208..352
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50054"
FT DOMAIN 272..333
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 179..202
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 410 AA; 45887 MW; EC4CC395970EF6F6 CRC64;
MPTSDVDEYT SIRDIRITKE WLLQQLRSDS KQIIILDCRS TNEYGESHIR QAVNFSIPSI
MLRRLSAGKI DLISTIKCKG LKEKILEGYK RDLFVIYGDD LNDTEKNNNT KEILHVLMKR
LKQDGCKVVC LQEGFTKFFN SYPEWCESAA DINLPGSDPV ATPLMGLRSL RISARSSCGS
SAATSSTESS DSDDRCDSSL GLEDDRDFPV EILPHLYLGN AINSEDSESL NKHGIQYILN
VTADLPNVFE DCGSMKYMQI PIADHWSENL AKFFPKAIKF IADEGRNNSK GVLVHCLAGV
SRSVTITVAY LMYKLKLSLN DAFTLVRNRK SNVGPNFHFM EQLHNFEQEL KIQGTLPDVS
IHGKKCSKCD CFVLECKCKS SRFLSPLAIG TSPDSGIEFD RWAPPPGSGE
//
