ID E0VEE1_PEDHC Unreviewed; 669 AA.
AC E0VEE1;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN Name=8234161 {ECO:0000313|EnsemblMetazoa:PHUM131490-PA};
GN ORFNames=Phum_PHUM131490 {ECO:0000313|EMBL:EEB11747.1};
OS Pediculus humanus subsp. corporis (Body louse).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Paraneoptera; Psocodea; Phthiraptera; Anoplura; Pediculidae;
OC Pediculus.
OX NCBI_TaxID=121224;
RN [1] {ECO:0000313|EMBL:EEB11747.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB11747.1};
RA Kirkness E., Hannick L., Hass B., Bruggner R., Lawson D., Bidwell S.,
RA Joardar V., Caler E., Walenz B., Inman J., Schobel S., Galinsky K.,
RA Amedeo P., Strausberg R.;
RT "Annotation of Pediculus humanus corporis strain USDA.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EEB11747.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB11747.1};
RG The Human Body Louse Genome Consortium;
RA Kirkness E., Walenz B., Hass B., Bruggner R., Strausberg R.;
RT "The genome of the human body louse.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:PHUM131490-PA}
RP IDENTIFICATION.
RC STRAIN=USDA {ECO:0000313|EnsemblMetazoa:PHUM131490-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
CC -!- SIMILARITY: Belongs to the DEAD box helicase family. DDX27/DRS1
CC subfamily. {ECO:0000256|ARBA:ARBA00043999}.
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DR EMBL; AAZO01001525; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS235090; EEB11747.1; -; Genomic_DNA.
DR RefSeq; XP_002424485.1; XM_002424440.1.
DR AlphaFoldDB; E0VEE1; -.
DR STRING; 121224.E0VEE1; -.
DR EnsemblMetazoa; PHUM131490-RA; PHUM131490-PA; PHUM131490.
DR GeneID; 8234161; -.
DR KEGG; phu:Phum_PHUM131490; -.
DR CTD; 8234161; -.
DR VEuPathDB; VectorBase:PHUM131490; -.
DR eggNOG; KOG0338; Eukaryota.
DR HOGENOM; CLU_003041_3_3_1; -.
DR InParanoid; E0VEE1; -.
DR OMA; ERRTWFQ; -.
DR OrthoDB; 149428at2759; -.
DR Proteomes; UP000009046; Unassembled WGS sequence.
DR GO; GO:0043229; C:intracellular organelle; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR CDD; cd17947; DEADc_DDX27; 1.
DR CDD; cd18787; SF2_C_DEAD; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000629; RNA-helicase_DEAD-box_CS.
DR InterPro; IPR014014; RNA_helicase_DEAD_Q_motif.
DR PANTHER; PTHR47959; ATP-DEPENDENT RNA HELICASE RHLE-RELATED; 1.
DR PANTHER; PTHR47959:SF14; DEAD-BOX ATP-DEPENDENT RNA HELICASE 28; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00039; DEAD_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS51195; Q_MOTIF; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU000492};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|RuleBase:RU000492};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU000492};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU000492};
KW Reference proteome {ECO:0000313|Proteomes:UP000009046}.
FT DOMAIN 155..183
FT /note="DEAD-box RNA helicase Q"
FT /evidence="ECO:0000259|PROSITE:PS51195"
FT DOMAIN 186..361
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 372..535
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 18..48
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 97..120
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 573..669
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 155..183
FT /note="Q motif"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00552"
FT COMPBIAS 97..111
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 573..619
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 620..636
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 647..669
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 669 AA; 75947 MW; A5F4A1E2DDECC2CD CRC64;
MCERASASPK FDLIKTINDG DEVSNFSEES NEEEEFQPNK EKSTGNKEFS AGFNFDSTGD
CNQDSWSYIT KFVKRTPKRK TEDKIELIKN KKKLSAENGE NGIKVENSTD EEGDDYLSDS
DLQHDNIKIK ELKKSKKKKT ELEFSEEISE NHDITSFYQM NLSRPLMKAI AAMNFSHPTP
IQCAAIPVAL LGRDICGCAA TGTGKTAAYM LPILERLLYK PQGSLSITRV LVLVPTRELG
VQVIQVAKQL SKFTTIEIGL AVGGLDVKVQ EAFLRKQPDI VIATPGRLID HLKNSLGFSL
DSIEILVLDE ADRMLDEYFA EQMKEIVRQC SRTRQTMLFS ATMTTAVEDL ASVSLSNPVK
IFVDSNQSVT NNLRQEFIRI RKGREGDKEA VLAALVRRTF RANCIIFVAT KSQAHKLRIL
LGFLNMKAGE LHGNLRQPER LDTLKRFKNG ELDILVATDV AARGLDISGV KTVINYDLPM
TFEHYIHRVG RTARAGRSGI SVSLACESER KLVKEIVKKA ERPVKSRIIP PQILLKYKKK
VEELGEDVDK VLKEELEERL LQKAEMQMNA MEKKLKSNDN NNDYDKTREW FQTKKQRSDE
KRKLKKKRET EVEKNNKVKK QIGKGKRKKK EKILPPRKPP KKGFKTSGGN KRNERDSTKK
KKGKRSVFD
//
