ID E0VKP6_PEDHC Unreviewed; 842 AA.
AC E0VKP6;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE RecName: Full=Replication factor C subunit 1 {ECO:0000256|ARBA:ARBA00020401, ECO:0000256|PIRNR:PIRNR036578};
GN Name=8235573 {ECO:0000313|EnsemblMetazoa:PHUM268450-PA};
GN ORFNames=Phum_PHUM268450 {ECO:0000313|EMBL:EEB13952.1};
OS Pediculus humanus subsp. corporis (Body louse).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Paraneoptera; Psocodea; Phthiraptera; Anoplura; Pediculidae;
OC Pediculus.
OX NCBI_TaxID=121224;
RN [1] {ECO:0000313|EMBL:EEB13952.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB13952.1};
RA Kirkness E., Hannick L., Hass B., Bruggner R., Lawson D., Bidwell S.,
RA Joardar V., Caler E., Walenz B., Inman J., Schobel S., Galinsky K.,
RA Amedeo P., Strausberg R.;
RT "Annotation of Pediculus humanus corporis strain USDA.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EEB13952.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB13952.1};
RG The Human Body Louse Genome Consortium;
RA Kirkness E., Walenz B., Hass B., Bruggner R., Strausberg R.;
RT "The genome of the human body louse.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:PHUM268450-PA}
RP IDENTIFICATION.
RC STRAIN=USDA {ECO:0000313|EnsemblMetazoa:PHUM268450-PA};
RG EnsemblMetazoa;
RL Submitted (FEB-2021) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PIRNR:PIRNR036578}.
CC -!- SIMILARITY: Belongs to the activator 1 large subunit family.
CC {ECO:0000256|ARBA:ARBA00006116, ECO:0000256|PIRNR:PIRNR036578}.
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DR EMBL; AAZO01003104; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAZO01003105; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS235250; EEB13952.1; -; Genomic_DNA.
DR RefSeq; XP_002426690.1; XM_002426645.1.
DR AlphaFoldDB; E0VKP6; -.
DR STRING; 121224.E0VKP6; -.
DR EnsemblMetazoa; PHUM268450-RA; PHUM268450-PA; PHUM268450.
DR GeneID; 8235573; -.
DR KEGG; phu:Phum_PHUM268450; -.
DR CTD; 8235573; -.
DR VEuPathDB; VectorBase:PHUM268450; -.
DR eggNOG; KOG1968; Eukaryota.
DR HOGENOM; CLU_003574_0_0_1; -.
DR InParanoid; E0VKP6; -.
DR OMA; VKFPTWL; -.
DR OrthoDB; 6297at2759; -.
DR Proteomes; UP000009046; Unassembled WGS sequence.
DR GO; GO:0005663; C:DNA replication factor C complex; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003689; F:DNA clamp loader activity; IEA:UniProtKB-UniRule.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd00009; AAA; 1.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 1.20.272.10; -; 1.
DR Gene3D; 3.40.50.10190; BRCT domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR001357; BRCT_dom.
DR InterPro; IPR036420; BRCT_dom_sf.
DR InterPro; IPR008921; DNA_pol3_clamp-load_cplx_C.
DR InterPro; IPR013725; DNA_replication_fac_RFC1_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR012178; RFC1.
DR PANTHER; PTHR23389; CHROMOSOME TRANSMISSION FIDELITY FACTOR 18; 1.
DR PANTHER; PTHR23389:SF6; REPLICATION FACTOR C SUBUNIT 1; 1.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF00533; BRCT; 1.
DR Pfam; PF08519; RFC1; 1.
DR PIRSF; PIRSF036578; RFC1; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00292; BRCT; 1.
DR SUPFAM; SSF52113; BRCT domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF48019; post-AAA+ oligomerization domain-like; 1.
DR PROSITE; PS50172; BRCT; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|PIRNR:PIRNR036578};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705,
KW ECO:0000256|PIRNR:PIRNR036578}; Ligase {ECO:0000313|EMBL:EEB13952.1};
KW Nucleotide-binding {ECO:0000256|PIRNR:PIRNR036578};
KW Nucleus {ECO:0000256|PIRNR:PIRNR036578};
KW Reference proteome {ECO:0000313|Proteomes:UP000009046}.
FT DOMAIN 119..181
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT REGION 24..63
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 71..90
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 803..842
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 842 AA; 95117 MW; A5BFA3BC971ED262 CRC64;
MAAFEFTNRN LLLTSFFNTN DEDKNCELKP GKIDSQSTTP KKEHGKSKKT KDNVSSNEIF
DEKKMGKISE ESSVITKKQE KNGSNTSIVV SKKQNSAAYQ KYLQRSGPKN PNSKTIPKGT
SNCLQNLTFV ITGILDSLEK KKAVELIQKY GGRVTTQVSK KTDFIVVGEE PGESKLSKAE
KFCTKKINED ELLALITERS NFKQEESKPI EKTEQIISNS SMKSSINENK KMNTSKSVMV
KSNQFDDLSL TGVTTKSEAS LIKNDDCKNN FENSDILWVE KYKPKSTKAI IGQGGEKSNV
KKLTYWLQNW HLNHSTKNDK KLTKPAPWNT NDDGSYFKAA LLSGPPGVGK TTSAYLICQE
LGFDIVEFNA SDTRSKRLLQ EEVSDLLTSK SLQGYFDGNR STFKKQVLLM DEVDGMSGNE
DRGGVQELIQ LIKQTKIPII GICNDRNHPK MRSLVNYCFD IRFQRPPIKQ IKAAMLSICF
KEKINISGDS LEELIVSSNH DLRQVLHRLS LLTFVEKSLS EEDARKNSSD GKKPLNLNPW
DVVRKVFSAS DNEKFNLNEK MDLFFQDYSL GPLFVQDAYI HVKPKKARNS ELEVMSLISK
AADSICYGDV VEKTIRSKNS WNLLPAQGLF ASICPGYYMA GHFQGKIEFP AWMGKNSKAR
KLSRILQELH TSLCTKILGD VQAINLDYLK LLKTIIVKPL IEENLNGVPT SVKFMVEHNI
NKDDFDHILE LCSWPGFKDS FSSIDSKIKS AFTRTLNKEN QKVSCVKKTS KMSQDNLDDE
NITDDIIFEE NDNIDFDPLI KKGKSKVKKD IKSPKETKMD KNKRSHATKE TPVNKGSKRL
KK
//
