ID E0VLV8_PEDHC Unreviewed; 884 AA.
AC E0VLV8;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 70.
DE RecName: Full=adenylate cyclase {ECO:0000256|ARBA:ARBA00012201};
DE EC=4.6.1.1 {ECO:0000256|ARBA:ARBA00012201};
GN Name=8229735 {ECO:0000313|EnsemblMetazoa:PHUM294440-PA};
GN ORFNames=Phum_PHUM294440 {ECO:0000313|EMBL:EEB14364.1};
OS Pediculus humanus subsp. corporis (Body louse).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Paraneoptera; Psocodea; Phthiraptera; Anoplura; Pediculidae;
OC Pediculus.
OX NCBI_TaxID=121224;
RN [1] {ECO:0000313|EMBL:EEB14364.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB14364.1};
RA Kirkness E., Hannick L., Hass B., Bruggner R., Lawson D., Bidwell S.,
RA Joardar V., Caler E., Walenz B., Inman J., Schobel S., Galinsky K.,
RA Amedeo P., Strausberg R.;
RT "Annotation of Pediculus humanus corporis strain USDA.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EEB14364.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB14364.1};
RG The Human Body Louse Genome Consortium;
RA Kirkness E., Walenz B., Hass B., Bruggner R., Strausberg R.;
RT "The genome of the human body louse.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:PHUM294440-PA}
RP IDENTIFICATION.
RC STRAIN=USDA {ECO:0000313|EnsemblMetazoa:PHUM294440-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP = 3',5'-cyclic AMP + diphosphate; Xref=Rhea:RHEA:15389,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:58165; EC=4.6.1.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001593};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl cyclase
CC family. {ECO:0000256|RuleBase:RU000405}.
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DR EMBL; AAZO01003413; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS235281; EEB14364.1; -; Genomic_DNA.
DR RefSeq; XP_002427102.1; XM_002427057.1.
DR AlphaFoldDB; E0VLV8; -.
DR STRING; 121224.E0VLV8; -.
DR EnsemblMetazoa; PHUM294440-RA; PHUM294440-PA; PHUM294440.
DR GeneID; 8229735; -.
DR KEGG; phu:Phum_PHUM294440; -.
DR CTD; 8229735; -.
DR VEuPathDB; VectorBase:PHUM294440; -.
DR eggNOG; KOG3619; Eukaryota.
DR HOGENOM; CLU_001072_2_5_1; -.
DR InParanoid; E0VLV8; -.
DR OMA; SKMVEFW; -.
DR OrthoDB; 3087296at2759; -.
DR Proteomes; UP000009046; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProtKB-EC.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006171; P:cAMP biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 2.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 2.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR018297; A/G_cyclase_CS.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR PANTHER; PTHR45627; ADENYLATE CYCLASE TYPE 1; 1.
DR PANTHER; PTHR45627:SF2; ADENYLATE CYCLASE TYPE 2; 1.
DR Pfam; PF00211; Guanylate_cyc; 2.
DR SMART; SM00044; CYCc; 2.
DR SUPFAM; SSF55073; Nucleotide cyclase; 2.
DR PROSITE; PS00452; GUANYLATE_CYCLASE_1; 2.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW cAMP biosynthesis {ECO:0000256|ARBA:ARBA00022998};
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000405};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022840};
KW Reference proteome {ECO:0000313|Proteomes:UP000009046};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 387..408
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 414..435
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 465..487
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 568..590
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 602..622
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 90..217
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT DOMAIN 689..833
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
SQ SEQUENCE 884 AA; 101680 MW; BF4B4EF5DBDB9204 CRC64;
MRGRKREGKD KGKAGIRKWM TELNHKKTFI GTKACIESRV KLECEKEQQE QLLLSVKRSI
MLKMANACQD TTNKQTRFHE MYVQRHNNVT ILYADIVNFT PLSEQLNASD LVKTLNELFG
RFDQIAQDNQ CMRIKILGDC YYCVSGLPVS RPNHAYNCVN MGLKMIEAIK FVREATGCDV
DMRIGIHTGN VLCGVLGLRK WQFDVWSDDV TLANYMESGG VPGRVHITKA TLLQLNGKFE
SEPGFGGDRE PFLADHKIET YLIIPPKVNK DDTAVDLESI DNNKIDNKND DDNNMKNNLK
TRSSSKMTKY VECWGADKPF ANITEATLAK NIGITSINML EPNLFTPKTS WWNIRNFINY
EDFHPIFLWL KNKEFEKKYR NLPDPYFKYY MIFSIALFLS ISFIQFLLTK RTFVFYGSFG
STAITLLTFL SLTWLKNCKN IKLSEIPSSE PLDYDTSRYT TSTRWLRLVI FMITTILIST
CSVITLLDSE NYYPENITIF NNNNNISSEN LLKDLNWTKD LQINFSDGDG DYDESNNLAP
CYLFSSTLTL ASISVFLKLG FMLKFSLMAF TSIIHIILYT NQPFFHYYYY YQNQIGNGFQ
ELSIHFKITI SFCITIILIH ILDRQIEFTS RTDFLWKAKL KVEQEEVETM RGINKILLEN
ILPEHVAEHF LTSSRLTQNL YHEKYSCIAV MFASIPNYKE FYDESDINKK GLECLRLLNE
IICDFDKLLL KPKFSCIEKI KTIGSTYMLA SGLSPGKEAN KDASRQKEHM VVILLEFAIA
LMTILDQINK ESFQRFKLRI GLNHGPVIAG VVGAQKPQYD IWGNTVNVAS RMDSCGIMGR
VQVTEDTAKI LQNAGYECEC RGPTYVKGKG MLITYFVKTQ FDDK
//
