ID E0VNM6_PEDHC Unreviewed; 533 AA.
AC E0VNM6;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=Class A rhodopsin-like G-protein coupled receptor GPRlrr, putative {ECO:0000313|EMBL:EEB14982.1, ECO:0000313|EnsemblMetazoa:PHUM337980-PA};
GN Name=8231840 {ECO:0000313|EnsemblMetazoa:PHUM337980-PA};
GN ORFNames=Phum_PHUM337980 {ECO:0000313|EMBL:EEB14982.1};
OS Pediculus humanus subsp. corporis (Body louse).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Paraneoptera; Psocodea; Phthiraptera; Anoplura; Pediculidae;
OC Pediculus.
OX NCBI_TaxID=121224;
RN [1] {ECO:0000313|EMBL:EEB14982.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB14982.1};
RA Kirkness E., Hannick L., Hass B., Bruggner R., Lawson D., Bidwell S.,
RA Joardar V., Caler E., Walenz B., Inman J., Schobel S., Galinsky K.,
RA Amedeo P., Strausberg R.;
RT "Annotation of Pediculus humanus corporis strain USDA.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EEB14982.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB14982.1};
RG The Human Body Louse Genome Consortium;
RA Kirkness E., Walenz B., Hass B., Bruggner R., Strausberg R.;
RT "The genome of the human body louse.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:PHUM337980-PA}
RP IDENTIFICATION.
RC STRAIN=USDA {ECO:0000313|EnsemblMetazoa:PHUM337980-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000256|ARBA:ARBA00010663, ECO:0000256|RuleBase:RU000688}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
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DR EMBL; AAZO01003929; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAZO01003930; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAZO01003931; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAZO01003932; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAZO01003933; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS235341; EEB14982.1; -; Genomic_DNA.
DR RefSeq; XP_002427720.1; XM_002427675.1.
DR STRING; 121224.E0VNM6; -.
DR EnsemblMetazoa; PHUM337980-RA; PHUM337980-PA; PHUM337980.
DR GeneID; 8231840; -.
DR KEGG; phu:Phum_PHUM337980; -.
DR CTD; 8231840; -.
DR VEuPathDB; VectorBase:PHUM337980; -.
DR eggNOG; KOG0619; Eukaryota.
DR eggNOG; KOG2087; Eukaryota.
DR HOGENOM; CLU_006130_2_1_1; -.
DR InParanoid; E0VNM6; -.
DR OrthoDB; 2913881at2759; -.
DR Proteomes; UP000009046; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR CDD; cd00112; LDLa; 1.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 2.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR24372; GLYCOPROTEIN HORMONE RECEPTOR; 1.
DR PANTHER; PTHR24372:SF77; GPR INSULIN LIKE RECEPTOR 1; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR Pfam; PF00057; Ldl_recept_a; 1.
DR Pfam; PF13855; LRR_8; 2.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR SMART; SM00192; LDLa; 1.
DR SMART; SM00369; LRR_TYP; 6.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 2.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF57424; LDL receptor-like module; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
DR PROSITE; PS50068; LDLRA_2; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040,
KW ECO:0000256|RuleBase:RU000688};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU000688};
KW Reference proteome {ECO:0000313|Proteomes:UP000009046};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transducer {ECO:0000256|ARBA:ARBA00023224, ECO:0000256|RuleBase:RU000688};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000688};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 265..283
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 295..316
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 336..361
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 382..401
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 407..428
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 277..401
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
SQ SEQUENCE 533 AA; 60588 MW; 48AC9B3397EFB876 CRC64;
MCSNSTLCIP QKSICNGYPD CPEGEDESVK MCADFFGSEF ITNILQGVKH DKANYETCDL
KKIPKECKCK NKTYLYCKNK GLNKLPIGIS ENVTRLILAN NTLNNLNDDT FEKYHDLNLI
HLEGNDIETL PKNLFQHQKN LTKLLLENNF LEIISGDTFS HLKNLQFLSV RQNKIRQIHS
HXXNNFIKTD LSYNYLHTLP ENIFLGLTNL KKLNLQEIEI SNVDVGMFDI MKNLKFIYLK
NFYYCTFAPQ LSTSENLLGR PVLRVPVWIV AFLTCVGNVY VFWERISTRN DENKVLSWII
RNLAVSDLAM GIYLIVIGYK DIQYRGYYHK MSHEWISSWT CTIIGSIAML SSEVSIIILV
FMSLERFLLI AVPFGGHKNL NWKTSCFSLG SIWAFGLSLA LVPADVYSWI SVFVIPVNSA
FNPLLYTLTT PKYREAIKYT ITRRMQPFAN SRHQSSTADT ISHTSSHKNA IGFCTVSVLS
GNSKNNSFDL QTCNTSVDRT SSLNLDEFSA ISLSTGQSSR GNSFDLPGTC FEH
//
