ID E0VNQ0_PEDHC Unreviewed; 1453 AA.
AC E0VNQ0;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 81.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
GN Name=8231830 {ECO:0000313|EnsemblMetazoa:PHUM339220-PA};
GN ORFNames=Phum_PHUM339220 {ECO:0000313|EMBL:EEB15006.1};
OS Pediculus humanus subsp. corporis (Body louse).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Paraneoptera; Psocodea; Phthiraptera; Anoplura; Pediculidae;
OC Pediculus.
OX NCBI_TaxID=121224;
RN [1] {ECO:0000313|EMBL:EEB15006.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB15006.1};
RA Kirkness E., Hannick L., Hass B., Bruggner R., Lawson D., Bidwell S.,
RA Joardar V., Caler E., Walenz B., Inman J., Schobel S., Galinsky K.,
RA Amedeo P., Strausberg R.;
RT "Annotation of Pediculus humanus corporis strain USDA.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EEB15006.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB15006.1};
RG The Human Body Louse Genome Consortium;
RA Kirkness E., Walenz B., Hass B., Bruggner R., Strausberg R.;
RT "The genome of the human body louse.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:PHUM339220-PA}
RP IDENTIFICATION.
RC STRAIN=USDA {ECO:0000313|EnsemblMetazoa:PHUM339220-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC Receptor class 2A subfamily. {ECO:0000256|ARBA:ARBA00010504}.
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DR EMBL; AAZO01003943; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS235341; EEB15006.1; -; Genomic_DNA.
DR RefSeq; XP_002427744.1; XM_002427699.1.
DR STRING; 121224.E0VNQ0; -.
DR EnsemblMetazoa; PHUM339220-RA; PHUM339220-PA; PHUM339220.
DR GeneID; 8231830; -.
DR KEGG; phu:Phum_PHUM339220; -.
DR CTD; 8231830; -.
DR VEuPathDB; VectorBase:PHUM339220; -.
DR eggNOG; KOG4228; Eukaryota.
DR HOGENOM; CLU_001645_5_2_1; -.
DR InParanoid; E0VNQ0; -.
DR OMA; YSVQRGP; -.
DR OrthoDB; 2875525at2759; -.
DR Proteomes; UP000009046; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR GO; GO:0048666; P:neuron development; IEA:UniProt.
DR CDD; cd00063; FN3; 3.
DR CDD; cd00047; PTPc; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 5.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 2.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013151; Immunoglobulin.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR46957; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR46957:SF7; PROTEIN-TYROSINE-PHOSPHATASE; 1.
DR Pfam; PF00041; fn3; 2.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF00047; ig; 1.
DR Pfam; PF00102; Y_phosphatase; 2.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 3.
DR SMART; SM00409; IG; 2.
DR SMART; SM00408; IGc2; 2.
DR SMART; SM00194; PTPc; 2.
DR SMART; SM00404; PTPc_motif; 2.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 2.
DR PROSITE; PS50853; FN3; 3.
DR PROSITE; PS50835; IG_LIKE; 2.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 2.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 2.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Receptor {ECO:0000313|EMBL:EEB15006.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000009046};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transferase {ECO:0000313|EMBL:EEB15006.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..30
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 785..807
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 28..130
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 153..215
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 233..329
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 334..427
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 431..540
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 872..1138
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1055..1129
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT DOMAIN 1170..1438
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1347..1429
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
SQ SEQUENCE 1453 AA; 165597 MW; 27D82769D2B983A7 CRC64;
MLAKKDLIKF HYCYLFFFIL LSLIFIVPLI TANGDYKIDY VNIHGPNKTQ LGSNLTLKCV
SSPNNSIVWW SFNGQNITSQ ERFHIQKTVV DFSVVLKLVV AKVEKVDIGN YSCHVVLPEN
NELQASKNIF VDVILKGRVL SSNTVRVLKE KDATLKCEME GYPLSNPEWK IEKSGLSDLL
PQNIHNNFIN ETYLETELSF QNVNHHDNGS YICRALGPDG YFQSSVHLFV LDKPQVVIDF
VKAVGANVLF FNWTVNDGND PVKEFYPQYK KNGSNEWVYY PERVGGGNTS FLLQNLNKNT
LYQVGISARN SIGRGEVYTR DEWVSTLEKD PTFVPEVTVK GTTSNSVSLG WTQPPPDVKD
YVQYYQIILQ NNETKQETIH PSSFMNAYLF TNLISATNYK IKIAACSEYL KKCGNWSEEV
NGTTLDGVSD PPINVSVQCR FDNISHASFV YVTWQPPANP YGQITHYNVI LQGVANFRND
KGIFENMTYG PKAKSIAAET TWARFEVVPP NTNYTIHVSG VTRSRHVGRE EVKHCSMPPT
IPEKEKLLRI DWKKIESEKG KWLFRLNLQR VSERNGAICC YMVYVVKLRP GQRASDLPNP
ENIPLSSYEQ VHRNISGGAY IAETFDSLSL NEEIFLGDGK TSNLNNSPCK YCINIHHIKK
ASTTASPPVV ININPTDRVR ESNDLKTNDI FKRLKRTSFQ PENDFVIFES TTPTINSLSS
SSSSSVNDIA YDGVLDRHFN YTGFVEIIVY GENGNFIPAY SKYFMPMCPG PTMLTAIDNS
RQLTIALYVL IGLIIVVFIL LIILFVLHNY TKTVAEEQGI EMTFTNTLMH LCRNVGGRHV
PISSSPPDIP PIPKAELAAA VAELHRDSDY GFQHEFELLP DRFPDRTTRA SEARENFYKN
RYPDIKAYDQ TRVKLSTVDG IIGSDYINAN YVMGYKERKK FICAQGPMDN TVNDFWRMVW
EQHLEMILML TNLEEYSKTK CAKYWPDAQT GEKKFGDFVV SHVHEKRYSD YIIRDLKLRQ
VSAESPVEKE KDEERMIVQY HYLVWKDFVA PEHPSGILKF IKRINEEYSL EKGPILIHCS
AGVGRTGTLV ALDSLLQQLN EEKQVAVFNT VCDLRHQRNF LVQSLKQYIF IYRALLEVSQ
SGDTEIKMAS LKSHVEKLKQ KESGKDKCML EEEFDKLEVL VNDRGKTYSV GSSEENKMKN
RSEDVIPYDR NRVMLAPIPG KDHSTYINAS FIEGYDNSES FIITQDPLPG TLSDFWRMIS
EQCVSTLVML SDLGDGPRKC IRYWPEPDDE SCYDNIKVKY IQSESCPYYT RREFAVTNMK
NDDSIITTQY QYNGWPTVEG EVPEVTRGLI QLVDQTQENR ILSSASEGGS PGGPMVVHCN
LGAERSSIFV ALSILVQQLK TEKSVDIFST ARKLKCQRHK MLENYVQYEF LHRAIVNYAD
LHHMTENGTT SPL
//