ID E0VPP9_PEDHC Unreviewed; 516 AA.
AC E0VPP9;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Voltage-activated ion channel, putative {ECO:0000313|EMBL:EEB15355.1, ECO:0000313|EnsemblMetazoa:PHUM362770-PA};
GN Name=8233414 {ECO:0000313|EnsemblMetazoa:PHUM362770-PA};
GN ORFNames=Phum_PHUM362770 {ECO:0000313|EMBL:EEB15355.1};
OS Pediculus humanus subsp. corporis (Body louse).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Paraneoptera; Psocodea; Phthiraptera; Anoplura; Pediculidae;
OC Pediculus.
OX NCBI_TaxID=121224;
RN [1] {ECO:0000313|EMBL:EEB15355.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB15355.1};
RA Kirkness E., Hannick L., Hass B., Bruggner R., Lawson D., Bidwell S.,
RA Joardar V., Caler E., Walenz B., Inman J., Schobel S., Galinsky K.,
RA Amedeo P., Strausberg R.;
RT "Annotation of Pediculus humanus corporis strain USDA.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EEB15355.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB15355.1};
RG The Human Body Louse Genome Consortium;
RA Kirkness E., Walenz B., Hass B., Bruggner R., Strausberg R.;
RT "The genome of the human body louse.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:PHUM362770-PA}
RP IDENTIFICATION.
RC STRAIN=USDA {ECO:0000313|EnsemblMetazoa:PHUM362770-PA};
RG EnsemblMetazoa;
RL Submitted (FEB-2021) to UniProtKB.
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DR EMBL; AAZO01004216; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS235370; EEB15355.1; -; Genomic_DNA.
DR RefSeq; XP_002428093.1; XM_002428048.1.
DR AlphaFoldDB; E0VPP9; -.
DR STRING; 121224.E0VPP9; -.
DR EnsemblMetazoa; PHUM362770-RA; PHUM362770-PA; PHUM362770.
DR GeneID; 8233414; -.
DR KEGG; phu:Phum_PHUM362770; -.
DR CTD; 8233414; -.
DR VEuPathDB; VectorBase:PHUM362770; -.
DR eggNOG; KOG0500; Eukaryota.
DR HOGENOM; CLU_528194_0_0_1; -.
DR InParanoid; E0VPP9; -.
DR OMA; CKENTWS; -.
DR OrthoDB; 5404347at2759; -.
DR Proteomes; UP000009046; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005261; F:monoatomic cation channel activity; IEA:UniProt.
DR CDD; cd00038; CAP_ED; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR PANTHER; PTHR10217:SF435; POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN EAG; 1.
DR PANTHER; PTHR10217; VOLTAGE AND LIGAND GATED POTASSIUM CHANNEL; 1.
DR Pfam; PF00027; cNMP_binding; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR SMART; SM00100; cNMP; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000009046};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 180..205
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 232..249
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 261..281
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 360..481
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT REGION 485..516
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 489..516
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 516 AA; 59810 MW; BD1FAB62B6293D76 CRC64;
MIRSTGNGGL FGNISKKSFS LSSITVTAAT NVDILQLNSQ IFFKYLENLP NTASLIEFLT
KRTEDYILPM QDEMDPLKYD FFESSDDTLP FEVTLHLSYY DKFGNYVINS QRISKRYLSS
KKSLVYDLLA NVPFETFCIA APRNWKLMVL SILRLNRILR LHYVREFYNW KDKQLMTNFL
ILKITWVVLN GALVIHIFAA LWYFISKPFG YEIKNSWVIS TFGVRNLTSR DLYAMSMYYV
ITLTTTTGYG DIRTNTVMEL LMSVFFMNVN PVFAGSVAGV INNKMTPLLQ YQVTALNLEN
SLKFQKTSMF LIEKIKSYVK YFWDLRAIKE IPQFIKNAPY SLQCEVMTAM YGHHLSQSFI
FYNLGDRFLT QLSTHLKRSI YFTGNYVVQQ GDIDQTMYFI NSGEISVLTI HPDLTETIHF
TLHANDSFGI RQGLQIEAEH HFSYRARCQT EVLLLLLSEW QQLLKYFPDV RTEIYQRLQS
LPSENVKVEP VDDTAESGAE DTVKDTPQDT SKPKDK
//
