ID E0VPV8_PEDHC Unreviewed; 1507 AA.
AC E0VPV8;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 89.
DE SubName: Full=Ras GTP exchange factor, son of sevenless, putative {ECO:0000313|EMBL:EEB15414.1};
GN Name=8233474 {ECO:0000313|EnsemblMetazoa:PHUM366140-PA};
GN ORFNames=Phum_PHUM366140 {ECO:0000313|EMBL:EEB15414.1};
OS Pediculus humanus subsp. corporis (Body louse).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Paraneoptera; Psocodea; Phthiraptera; Anoplura; Pediculidae;
OC Pediculus.
OX NCBI_TaxID=121224;
RN [1] {ECO:0000313|EMBL:EEB15414.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB15414.1};
RA Kirkness E., Hannick L., Hass B., Bruggner R., Lawson D., Bidwell S.,
RA Joardar V., Caler E., Walenz B., Inman J., Schobel S., Galinsky K.,
RA Amedeo P., Strausberg R.;
RT "Annotation of Pediculus humanus corporis strain USDA.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EEB15414.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB15414.1};
RG The Human Body Louse Genome Consortium;
RA Kirkness E., Walenz B., Hass B., Bruggner R., Strausberg R.;
RT "The genome of the human body louse.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:PHUM366140-PA}
RP IDENTIFICATION.
RC STRAIN=USDA {ECO:0000313|EnsemblMetazoa:PHUM366140-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
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DR EMBL; AAZO01004262; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS235379; EEB15414.1; -; Genomic_DNA.
DR RefSeq; XP_002428152.1; XM_002428107.1.
DR STRING; 121224.E0VPV8; -.
DR EnsemblMetazoa; PHUM366140-RA; PHUM366140-PA; PHUM366140.
DR GeneID; 8233474; -.
DR KEGG; phu:Phum_PHUM366140; -.
DR CTD; 8233474; -.
DR VEuPathDB; VectorBase:PHUM366140; -.
DR eggNOG; KOG3417; Eukaryota.
DR HOGENOM; CLU_002744_2_1_1; -.
DR InParanoid; E0VPV8; -.
DR OMA; KNTHRED; -.
DR OrthoDB; 68574at2759; -.
DR Proteomes; UP000009046; Unassembled WGS sequence.
DR GO; GO:0000786; C:nucleosome; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd01261; PH_SOS; 1.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 6.10.250.3060; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 1.10.20.10; Histone, subunit A; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR009072; Histone-fold.
DR InterPro; IPR002119; Histone_H2A.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF373; PROTEIN SON OF SEVENLESS; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR PRINTS; PR00620; HISTONEH2A.
DR SMART; SM00414; H2A; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF47113; Histone-fold; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000009046}.
FT DOMAIN 211..398
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 445..554
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 603..751
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 788..1026
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 1029..1212
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1372..1394
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1072..1089
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1116..1134
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1135..1156
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1193..1207
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1507 AA; 171588 MW; 2347FCD41E393EAD CRC64;
MFSSPSSAIE SQNYDFEKAE NAAKWKGVFV NSLRKVLEQV HSSLTARDDA LEYVESLILR
LLGMLCARPP PHTTQDVEER VRRTFPTPID RWALTDAKEA IEKGKKKSPL VLPVDRVHHL
LQKEVLQYKL DSQVSFYIVA VLEYISADIL KLAGNYVKNI RHVEITCQDI RVAMCADKVL
MDMFHQDEGG SSSSTATIEE SEGIQPRTSL TYEEVVKDLI HDEKQYLRDL HMIIKVFREE
IAKLTNNPKD LEDMFSNIMD IYELTITLLG SLEDMVEISE EKQLPAVGSC FEELAEAAEF
DVYGKYARDM MSSKSREALH RLLSRPEVSE TLHTAGQGFC EAVKYYLPKL LLGPVWHCFL
YFDYMKVLNK LTPMVEDKES LEQVEGLLRP LQMELTSLIG NVARRDTNVR MHSRVRRQIA
IEKTNELQRS IDGWEGKDIG QCCNEFIRED VLGKLSSGKR LTERRAFLFD GLMVLCKPNS
KRTSVSVTTQ QTTAEFRLKE RFFIRKVYIT DKEDTEDLKN AFEISPRVQP SVILVAKSPE
DKNIWMADLI MLNTKSMLDR LLDSILLDEE KKHPLKLPPP HLYKFAEADS KDNIVLDETE
GSGVPLIKGA TLYKLIERLT YHIYADPMFV RTFLTTYRSF CSPQELLDLL VERFNIPEPQ
LFYDDNKETS ESDKTIKNSQ REDWKRFRKE YCQPVQFRVL NVLRHWVDHH FYDFERDATL
LEKLHHFLDT VNGKSMRKWV DSVLKIVQRK CDSNEIQREI TFAFDRSPPP IEWHIRCPEE
EWSILTLHPI EIARQLTLLE FELYRAVKPS ELVGSVWTKK DKEKTSPNLL KMIKHTTNFT
RWLEKNIIDA ENLEERIAIV SRIIEVMMVL QELNNFNGVL AVVSAMGSAG VFRLKFTFQA
LSARLDKALE EARELNAGHF KKYQQKLRSI NPPCVPFFGM YLTNILFIEE GNPDYLPNSP
KLINFSKRRK VAEITGEIQQ YQNQPYCFSV ELKIRHFLEN LCPFENQTDA EIGNYLFNKS
LEIEPRMCKQ PPRFPRKWPE LNLKSPGTKP KNLPGRSHPP MPLPSIDRHR SPSTMRLQED
QEPETPKTPH TPPHRPTPDL IDNTVFMPVL IGGRSGNQSP GGQVLVSSAT PSPGTSPSPA
HPPALPPPPP PPAKSIELVR LPSSKIVRSA VAPPLPPRRK KENSTGESIP DVPPRDQSPP
PLPPRSNPSH LQRRNSALDV GQNEGQTTVP RRHMSVNGPF LSTMPRSGHK ALPVNHQIST
MPAPTFHVPN HSQDTQSHGQ GVPPFYGHLS FGSHNLQATQ TAILGTHNLS QSCRNSGNFN
FNTNKPVTIG TGMTGMTTTT TPPITTAPHP LRHHPHVRNF ENVLENLELN NASSPTRKTS
HNFNFKSNSS DIDKQQQKTI LTAYGKNENS PKLLPENLGI PYPGEELSNR LTAVSPQKST
KEIKSSRLSG NQEDIHLNCI LSTPELPPKI HLGKKSPVYA KGSGETLFHF DSQKIHRMNS
SSQDGHS
//
