ID E0VSL0_PEDHC Unreviewed; 392 AA.
AC E0VSL0;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
GN Name=8234483 {ECO:0000313|EnsemblMetazoa:PHUM420140-PA};
GN ORFNames=Phum_PHUM420140 {ECO:0000313|EMBL:EEB16366.1};
OS Pediculus humanus subsp. corporis (Body louse).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Paraneoptera; Psocodea; Phthiraptera; Anoplura; Pediculidae;
OC Pediculus.
OX NCBI_TaxID=121224;
RN [1] {ECO:0000313|EMBL:EEB16366.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB16366.1};
RA Kirkness E., Hannick L., Hass B., Bruggner R., Lawson D., Bidwell S.,
RA Joardar V., Caler E., Walenz B., Inman J., Schobel S., Galinsky K.,
RA Amedeo P., Strausberg R.;
RT "Annotation of Pediculus humanus corporis strain USDA.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EEB16366.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB16366.1};
RG The Human Body Louse Genome Consortium;
RA Kirkness E., Walenz B., Hass B., Bruggner R., Strausberg R.;
RT "The genome of the human body louse.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:PHUM420140-PA}
RP IDENTIFICATION.
RC STRAIN=USDA {ECO:0000313|EnsemblMetazoa:PHUM420140-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
CC -!- SIMILARITY: Belongs to the MPI phosphatase family.
CC {ECO:0000256|ARBA:ARBA00011065}.
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DR EMBL; AAZO01005143; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS235751; EEB16366.1; -; Genomic_DNA.
DR RefSeq; XP_002429104.1; XM_002429059.1.
DR AlphaFoldDB; E0VSL0; -.
DR STRING; 121224.E0VSL0; -.
DR EnsemblMetazoa; PHUM420140-RA; PHUM420140-PA; PHUM420140.
DR GeneID; 8234483; -.
DR KEGG; phu:Phum_PHUM420140; -.
DR CTD; 8234483; -.
DR VEuPathDB; VectorBase:PHUM420140; -.
DR eggNOG; KOG3772; Eukaryota.
DR HOGENOM; CLU_014464_3_0_1; -.
DR InParanoid; E0VSL0; -.
DR OMA; CEPCAYR; -.
DR OrthoDB; 12481at2759; -.
DR Proteomes; UP000009046; Unassembled WGS sequence.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:1902751; P:positive regulation of cell cycle G2/M phase transition; IEA:InterPro.
DR CDD; cd01530; Cdc25; 1.
DR Gene3D; 3.40.250.10; Rhodanese-like domain; 1.
DR InterPro; IPR000751; MPI_Phosphatase.
DR InterPro; IPR001763; Rhodanese-like_dom.
DR InterPro; IPR036873; Rhodanese-like_dom_sf.
DR PANTHER; PTHR10828:SF17; CDC25-LIKE PROTEIN PHOSPHATASE TWINE-RELATED; 1.
DR PANTHER; PTHR10828; M-PHASE INDUCER PHOSPHATASE DUAL SPECIFICITY PHOSPHATASE CDC25; 1.
DR Pfam; PF00581; Rhodanese; 1.
DR PRINTS; PR00716; MPIPHPHTASE.
DR SMART; SM00450; RHOD; 1.
DR SUPFAM; SSF52821; Rhodanese/Cell cycle control phosphatase; 1.
DR PROSITE; PS50206; RHODANESE_3; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:EEB16366.1};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Reference proteome {ECO:0000313|Proteomes:UP000009046}.
FT DOMAIN 225..347
FT /note="Rhodanese"
FT /evidence="ECO:0000259|PROSITE:PS50206"
FT REGION 59..89
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 392 AA; 44594 MW; 77709ADEC285B701 CRC64;
MKMSILRTIV LQFSNYKNKK EKSNTLSFGF PGSFDDGFLD VWDLEKSFTD ENEELPMGLG
NLLKGPLLGN SNGGKTEEEK GNCSRPPLRR FNSLAENYTS SPASSRARVG LFRDETVSKQ
SPGEKLPFKR PREIDSNSCK RRKSNSLHTI PDKVLKDAYK SRYKLQRSIS ETAASSLALT
LHKSDLIADF SRPYALPFVS GRHEDLKSIT SETLASLING EFNAKVNSFK IIDCRYPYEY
DGGHIIGSIN LYTKEQVEEE FFDNKGPLDA ADPSSSSSSD ENDGLNEKRN ILIFHCEFSL
ERGPALYRFL RRCDRNLSNY PSLHYPEVYL LHGGYKSFFS THKSLCEPCF YQPMVDPKHE
NDLKKFRVKS NSWSGDNKKQ TFRSGLKRLG LF
//
