GenomeNet

Database: UniProt
Entry: E0VU84_PEDHC
LinkDB: E0VU84_PEDHC
Original site: E0VU84_PEDHC 
ID   E0VU84_PEDHC            Unreviewed;      1837 AA.
AC   E0VU84;
DT   02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2010, sequence version 1.
DT   27-SEP-2017, entry version 49.
DE   SubName: Full=Dihydropyridine-sensitive L-type, skeletal muscle calcium channel alpha-1 subunit, putative {ECO:0000313|EMBL:EEB16940.1};
DE   SubName: Full=Dihydropyridine-sensitive L-type, skeletalmuscle calcium channel alpha-1 subunit, putative {ECO:0000313|VectorBase:PHUM447690-PA};
GN   Name=8231224 {ECO:0000313|VectorBase:PHUM447690-PA};
GN   ORFNames=Phum_PHUM447690 {ECO:0000313|EMBL:EEB16940.1};
OS   Pediculus humanus subsp. corporis (Body louse).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Paraneoptera; Psocodea; Phthiraptera; Anoplura;
OC   Pediculidae; Pediculus.
OX   NCBI_TaxID=121224 {ECO:0000313|Proteomes:UP000009046};
RN   [1] {ECO:0000313|EMBL:EEB16940.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=USDA {ECO:0000313|EMBL:EEB16940.1};
RA   Kirkness E., Hannick L., Hass B., Bruggner R., Lawson D., Bidwell S.,
RA   Joardar V., Caler E., Walenz B., Inman J., Schobel S., Galinsky K.,
RA   Amedeo P., Strausberg R.;
RT   "Annotation of Pediculus humanus corporis strain USDA.";
RL   Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:EEB16940.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=USDA {ECO:0000313|EMBL:EEB16940.1};
RG   The Human Body Louse Genome Consortium;
RA   Kirkness E., Walenz B., Hass B., Bruggner R., Strausberg R.;
RT   "The genome of the human body louse.";
RL   Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Proteomes:UP000009046, ECO:0000313|VectorBase:PHUM447690-PA}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=USDA {ECO:0000313|Proteomes:UP000009046,
RC   ECO:0000313|VectorBase:PHUM447690-PA};
RX   PubMed=20566863; DOI=10.1073/pnas.1003379107;
RA   Kirkness E.F., Haas B.J., Sun W., Braig H.R., Perotti M.A.,
RA   Clark J.M., Lee S.H., Robertson H.M., Kennedy R.C., Elhaik E.,
RA   Gerlach D., Kriventseva E.V., Elsik C.G., Graur D., Hill C.A.,
RA   Veenstra J.A., Walenz B., Tubio J.M., Ribeiro J.M., Rozas J.,
RA   Johnston J.S., Reese J.T., Popadic A., Tojo M., Raoult D., Reed D.L.,
RA   Tomoyasu Y., Krause E., Mittapalli O., Margam V.M., Li H.M.,
RA   Meyer J.M., Johnson R.M., Romero-Severson J., Vanzee J.P.,
RA   Alvarez-Ponce D., Vieira F.G., Aguade M., Guirao-Rico S., Anzola J.M.,
RA   Yoon K.S., Strycharz J.P., Unger M.F., Christley S., Lobo N.F.,
RA   Seufferheld M.J., Wang N., Dasch G.A., Struchiner C.J., Madey G.,
RA   Hannick L.I., Bidwell S., Joardar V., Caler E., Shao R., Barker S.C.,
RA   Cameron S., Bruggner R.V., Regier A., Johnson J., Viswanathan L.,
RA   Utterback T.R., Sutton G.G., Lawson D., Waterhouse R.M., Venter J.C.,
RA   Strausberg R.L., Berenbaum M.R., Collins F.H., Zdobnov E.M.,
RA   Pittendrigh B.R.;
RT   "Genome sequences of the human body louse and its primary endosymbiont
RT   provide insights into the permanent parasitic lifestyle.";
RL   Proc. Natl. Acad. Sci. U.S.A. 107:12168-12173(2010).
RN   [4] {ECO:0000313|VectorBase:PHUM447690-PA}
RP   IDENTIFICATION.
RC   STRAIN=USDA {ECO:0000313|VectorBase:PHUM447690-PA};
RG   VectorBase;
RL   Submitted (FEB-2017) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
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DR   EMBL; DS235783; EEB16940.1; -; Genomic_DNA.
DR   RefSeq; XP_002429678.1; XM_002429633.1.
DR   STRING; 121225.PHUM447690-PA; -.
DR   EnsemblMetazoa; PHUM447690-RA; PHUM447690-PA; PHUM447690.
DR   GeneID; 8231224; -.
DR   KEGG; phu:Phum_PHUM447690; -.
DR   VectorBase; PHUM447690-RA; PHUM447690-PA; PHUM447690.
DR   CTD; 8231224; -.
DR   InParanoid; E0VU84; -.
DR   OMA; DSPRNNA; -.
DR   PhylomeDB; E0VU84; -.
DR   Proteomes; UP000009046; Partially assembled WGS sequence.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   SMART; SM01062; Ca_chan_IQ; 1.
DR   SMART; SM00054; EFh; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   PROSITE; PS00018; EF_HAND_1; 1.
DR   PROSITE; PS50222; EF_HAND_2; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|PROSITE-ProRule:PRU00448,
KW   ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000009046};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009046};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM    187    209       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    275    296       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    308    330       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    458    476       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    488    506       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    583    606       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    657    683       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    789    806       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    826    847       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    856    874       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    923    945       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1037   1062       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1118   1136       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1148   1170       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1190   1211       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1239   1262       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1282   1306       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1327   1351       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1367   1402       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   CA_BIND    1380   1391       {ECO:0000256|PROSITE-ProRule:PRU00448}.
FT   COILED      686    721       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1837 AA;  209424 MW;  47979A83845D12E7 CRC64;
     MIVFFFFGFR LAAAQEAAAQ QRALPPGRDC PPSPGTMGKH SQQPPGAKQP TSLFIFGEEN
     IEKTETYFLC IFCVEASLKI LALGFVLHRG SYLRNIWNMM DFVVVVDDHI RGIECGRRSS
     NAAIFPRVEA FEIGFADPKF VTMVPGDVGL DLRTLRAIRV LRPLKLVSGI PSLQVVLKSI
     IKAMAPLLQI GLLVLFAIVI FAIIGLEFYS GALHKTCYSL EDLTKIVEEG DAATPCNTDN
     ESIAQPGSFI CNPNISTCME EWEGPNYGIT SFDNIGFAML TVFQCITMEG WTAILYWTND
     AQGSKYNWIY FVPLIVVGSF FMLNLVLGVL SGEFANQREK VENRQTFLKL RTQQLLEREL
     NGYVEWISKA EEVILNEERT TEEEKMHIIE ARRRAAAKRK KLKNLGKSKS TDTEEEEEEV
     EEGFSRSYLK AKVKNKGAFW RAEKRLRFWI RHAVKTQVFY WFVIVLVFLN TICVAVEHYD
     QPPWLTSFLY YTEFIFLGLF LIEMFIKMYA LGPRIYFESA FNRFDCVVIS GSIFEVIWSQ
     IKSGSFGLSV LRALRLLRIF KVTKYWSSLR NLVISLLNSM RSIISLLFLL FLFILIFALL
     GMQLFGGQFN FDDGTPPTNF NTFPIALLTV FQILTGEDWN EVMYKGIESQ GGHKKGMIYS
     LYFVILMLFG NYTLLNVFLA IAVDNLANAQ ELTAAEEEQE EEDKEKQAQE LEKEMEALQM
     GGTLIEGDGN VPSPSHNLKE KRKKEEEKKV EADEELTGPR PMLPYTSMFI LSTTNPIRRA
     AHWVVNLKYF DFFIMVVISL SSIALAAEDP VEEESVRNSI LNYFDYAFTC VFTIEMILKI
     LDLGLILHPG SYLREFWNIM DAVVVICAAV SFGFDISGSS AGQNLSTIKS LRVLRVLRPL
     KTIKRVPKLK AVFDCVVNSL KNVINILIVY ILFQFIFAVI AVQLFNGKFY YCTDDSKATE
     KECQGQYFVF DKSSLLPRAD KRVWRAQDFH YDNVAVAMLT LFAVQTGEGW PQVLQNSMAA
     TYEDTGPIQN FRIEMSIFYI VYFVVFPFFF VNIFVALIII TFQEQGEAEL QDGEIDKNQK
     SCIDFTIQAR PLERYMPKER NSFKYKVWKL IASTSFEYFI MMLIVFNTLL LMMKFHKQSA
     LYKKSLHYLN MGFTTMFTIE TILKLLAYGI RNFFKDAWNT FDLITVLGSI VDVLFMEFGE
     NSFNVGFLRL FRAARLIKLL RQGYTIRILL WTFVQSFKAL PYVCLLIAML FFIYAIIGMQ
     VFGNMKFDPY SALNRHNNFQ TFFGALLLLF RCATGEAWPS IMLSCIKDRP CDVRANKGSE
     TCGSNLAYAY FVSFIFFCSF LMLNLFVAVI MDNFDYLTRD SSILGAHHLD EFVRIWAEYD
     PNATGKIDYT EMYDMLKNMD PPLGFGAKCP NRLAYKKLIR MNMPVDDKGK VNFTTTLFAL
     IRENLSIKVR AAEEMDQADE ELRKTIMKIW PLQSKKMIDL LVPQKEELGK GKLTVGKIYA
     GLLILESWRS TRFGQIESAG VPSVNGVLKI GIPSMPPSPK NPRVCFWGKI QPTGVPGFNV
     FPPLFLILMV NDLQNVTIES RRPSLESLQG DQNHRLHPGY GDQSTRTPSF RRRKSPSFMY
     KGVSPRRGGH PQQHDIGFSD TVSNVVDIVK HDRRGKPKGT WSTSTSPARS PSPSRVRYYS
     NRSRAYGTTS LEQRSRSPSP TGDRGPPPSV HHHHFHHHSH QHSYPVLVTR RGHGRRLPAT
     PSKPSTLQLR PSSINFPKLN ASPTHCPPLS SSSGGHHQIT TGQYCPLSFE QAVAIGRGGR
     VLPSPLLNGY KPGQQQHQHQ HQQRPRRHSD SDEDDWC
//
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