ID E0VUJ9_PEDHC Unreviewed; 762 AA.
AC E0VUJ9;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Dipeptidyl peptidase 4, putative {ECO:0000313|EMBL:EEB17055.1, ECO:0000313|EnsemblMetazoa:PHUM451260-PA};
DE EC=3.4.14.5 {ECO:0000313|EMBL:EEB17055.1};
GN Name=8230341 {ECO:0000313|EnsemblMetazoa:PHUM451260-PA};
GN ORFNames=Phum_PHUM451260 {ECO:0000313|EMBL:EEB17055.1};
OS Pediculus humanus subsp. corporis (Body louse).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Paraneoptera; Psocodea; Phthiraptera; Anoplura; Pediculidae;
OC Pediculus.
OX NCBI_TaxID=121224;
RN [1] {ECO:0000313|EMBL:EEB17055.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB17055.1};
RA Kirkness E., Hannick L., Hass B., Bruggner R., Lawson D., Bidwell S.,
RA Joardar V., Caler E., Walenz B., Inman J., Schobel S., Galinsky K.,
RA Amedeo P., Strausberg R.;
RT "Annotation of Pediculus humanus corporis strain USDA.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EEB17055.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB17055.1};
RG The Human Body Louse Genome Consortium;
RA Kirkness E., Walenz B., Hass B., Bruggner R., Strausberg R.;
RT "The genome of the human body louse.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:PHUM451260-PA}
RP IDENTIFICATION.
RC STRAIN=USDA {ECO:0000313|EnsemblMetazoa:PHUM451260-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
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DR EMBL; AAZO01005497; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS235786; EEB17055.1; -; Genomic_DNA.
DR RefSeq; XP_002429793.1; XM_002429748.1.
DR AlphaFoldDB; E0VUJ9; -.
DR ESTHER; pedhc-e0vuj9; DPP4N_Peptidase_S9.
DR EnsemblMetazoa; PHUM451260-RA; PHUM451260-PA; PHUM451260.
DR GeneID; 8230341; -.
DR KEGG; phu:Phum_PHUM451260; -.
DR CTD; 8230341; -.
DR VEuPathDB; VectorBase:PHUM451260; -.
DR eggNOG; KOG2100; Eukaryota.
DR HOGENOM; CLU_006105_4_0_1; -.
DR InParanoid; E0VUJ9; -.
DR OMA; YDVYDIA; -.
DR OrthoDB; 2876738at2759; -.
DR Proteomes; UP000009046; Unassembled WGS sequence.
DR GO; GO:0008239; F:dipeptidyl-peptidase activity; IEA:UniProtKB-EC.
DR GO; GO:0008236; F:serine-type peptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 2.140.10.30; Dipeptidylpeptidase IV, N-terminal domain; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR001375; Peptidase_S9.
DR InterPro; IPR002469; Peptidase_S9B_N.
DR PANTHER; PTHR11731; PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED; 1.
DR PANTHER; PTHR11731:SF154; VENOM DIPEPTIDYL PEPTIDASE 4-LIKE PROTEIN; 1.
DR Pfam; PF00930; DPPIV_N; 1.
DR Pfam; PF00326; Peptidase_S9; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF82171; DPP6 N-terminal domain-like; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000313|EMBL:EEB17055.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000009046};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..762
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5011412784"
FT DOMAIN 96..469
FT /note="Dipeptidylpeptidase IV N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00930"
FT DOMAIN 559..761
FT /note="Peptidase S9 prolyl oligopeptidase catalytic"
FT /evidence="ECO:0000259|Pfam:PF00326"
SQ SEQUENCE 762 AA; 88225 MW; 1369425DEFD67573 CRC64;
MIIRNVELFI IIIIGFVFVS SNPLKNDKTP FSIEESALGF YSVNSFFGTW ISDNEFEYQD
NDTKNIKILN LETNKTYVSL NRTVFNKYNS NKYKFSHDRN YVLIPYNETT VFRHTKTAQY
VVYSLKDGVY YHVSNKERLQ EADWGPKNNI LLFIKNNDIY VVTDIDENMN SVQVTNTGLH
GVVYNGMSDW VYEEEVLSTS KAYWFSPNGD QLLYLTLNDT RVKKATLFEY GEPGSLENQY
PKEVEIRYPK SGSTPPDFKL WHVTLKNVTL KKLFAQSKVI SSSSLITFSE DIFYGLKWAD
NDKFLYMMTN RVQNESKTYM CDLKQENPCQ IKFQHLKERG WANTEMPKVS ENLDRFLMLE
GISVGDSGKF KHLVLHKENG DSFSLTNGHF DVERILYWNQ KTKMVYYLAP EVNDSTTSQV
YAVSESNTNE KPECLTCHIK SPEGRFCKDA SGQFSKLGSY VVINCNGPDP RVVYLFKTEH
PLGKPLRVLE NNFKLRNQME GKIFPEVLNL NVDVVGGSFK ADVRLFLPPN MDKSGKTKYP
LLIYVYGGPG SKGISNTFKF DWGYYMSTNL SVIYGFIDGR NTLKKGENVL FAGYRALGTY
EMYDQINVTR TLQKQFPFID SNNTGIWGWS YGGYATTKVL EMDFNNVFKC GIAVAPVADW
LYYDSVYTER YMGLPEENKE GYKKSSTLYD VTNLLKKKYF LIHGNADDNV HYQNAMMLAR
VLEKKNIPFE LMSYPDENHS LLSVRKHLYH TMDRFWKRCF NL
//
