ID E0VV15_PEDHC Unreviewed; 1256 AA.
AC E0VV15;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE RecName: Full=Protein kibra {ECO:0000256|ARBA:ARBA00013712};
GN Name=8230669 {ECO:0000313|EnsemblMetazoa:PHUM457750-PA};
GN ORFNames=Phum_PHUM457750 {ECO:0000313|EMBL:EEB17221.1};
OS Pediculus humanus subsp. corporis (Body louse).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Paraneoptera; Psocodea; Phthiraptera; Anoplura; Pediculidae;
OC Pediculus.
OX NCBI_TaxID=121224;
RN [1] {ECO:0000313|EMBL:EEB17221.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB17221.1};
RA Kirkness E., Hannick L., Hass B., Bruggner R., Lawson D., Bidwell S.,
RA Joardar V., Caler E., Walenz B., Inman J., Schobel S., Galinsky K.,
RA Amedeo P., Strausberg R.;
RT "Annotation of Pediculus humanus corporis strain USDA.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EEB17221.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB17221.1};
RG The Human Body Louse Genome Consortium;
RA Kirkness E., Walenz B., Hass B., Bruggner R., Strausberg R.;
RT "The genome of the human body louse.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:PHUM457750-PA}
RP IDENTIFICATION.
RC STRAIN=USDA {ECO:0000313|EnsemblMetazoa:PHUM457750-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- FUNCTION: Regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a
CC signaling pathway that plays a pivotal role in organ size control and
CC tumor suppression by restricting proliferation and promoting apoptosis.
CC The core of this pathway is composed of a kinase cascade wherein Hippo
CC (Hpo), in complex with its regulatory protein Salvador (Sav),
CC phosphorylates and activates Warts (Wts) in complex with its regulatory
CC protein Mats, which in turn phosphorylates and inactivates the Yorkie
CC (Yki) oncoprotein. Kibra acts synergistically along with Ex and Mer to
CC regulate the Hippo signaling pathway. {ECO:0000256|ARBA:ARBA00024960}.
CC -!- SUBUNIT: Forms a complex with Mer and Ex. Interacts (via domain WW 1)
CC with Ex (via RXPPXY motif). Interacts with Mer, Sav, Hpo and Wts.
CC {ECO:0000256|ARBA:ARBA00025969}.
CC -!- SUBCELLULAR LOCATION: Apical cell membrane
CC {ECO:0000256|ARBA:ARBA00004221}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004236}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
CC -!- SIMILARITY: Belongs to the WWC family. KIBRA subfamily.
CC {ECO:0000256|ARBA:ARBA00010585}.
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DR EMBL; AAZO01005566; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS235800; EEB17221.1; -; Genomic_DNA.
DR RefSeq; XP_002429959.1; XM_002429914.1.
DR AlphaFoldDB; E0VV15; -.
DR STRING; 121224.E0VV15; -.
DR EnsemblMetazoa; PHUM457750-RA; PHUM457750-PA; PHUM457750.
DR GeneID; 8230669; -.
DR KEGG; phu:Phum_PHUM457750; -.
DR CTD; 8230669; -.
DR VEuPathDB; VectorBase:PHUM457750; -.
DR eggNOG; KOG0940; Eukaryota.
DR eggNOG; KOG3209; Eukaryota.
DR HOGENOM; CLU_005420_1_0_1; -.
DR InParanoid; E0VV15; -.
DR OMA; DTDYQYK; -.
DR OrthoDB; 1334597at2759; -.
DR Proteomes; UP000009046; Unassembled WGS sequence.
DR GO; GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell.
DR CDD; cd00201; WW; 2.
DR Gene3D; 2.20.70.10; -; 2.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR PANTHER; PTHR14791; BOMB/KIRA PROTEINS; 1.
DR PANTHER; PTHR14791:SF29; PROTEIN KIBRA; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF00397; WW; 1.
DR SMART; SM00239; C2; 1.
DR SMART; SM00456; WW; 2.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF51045; WW domain; 2.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS01159; WW_DOMAIN_1; 1.
DR PROSITE; PS50020; WW_DOMAIN_2; 2.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000009046}.
FT DOMAIN 9..42
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 56..89
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 691..811
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 424..447
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 480..509
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 619..640
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 829..862
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1127..1183
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 166..193
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 230..257
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 295..322
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 354..396
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1013..1043
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 843..857
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1128..1142
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1147..1169
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1256 AA; 140965 MW; 9003A2487CFFC8CB CRC64;
MPRRRNGELP LPEGWEYATD DDGKVYFIDH VTKKTTWIDP RDRFTKPQTF ADCIGNELPL
GWEEAYDAQI GVYYINHVNQ CTQLEDPRLE WRAIQEAMLR DYLQTAQDAL EAKKEIFDVK
QQRLYLAEDE YNHLNNALTT LNKSRSSLCS NVSSTKYDPD LLKSDVALAR NRVSRLKREL
EQIKTEMTCT QRGVETLASV EQKLSGQGGY YNLSEAQAIV TELKNIQMSL SSGEKEKAEL
MQSLAKLKDD LTRLQLSESS PDVSTLSLPQ EKLSTASQTD LSGELVPIGT RLAEMARTRL
QYDEARKRVQ LVQRKLADLE EKVTPGQAES DKDRLLLFQE KEQLLRELRS MTPRSRSAQE
MTDIQLEVKR LERDLNQALE LNNRAIADRV RLHEEKQILL QELCEALRTM TSLESQLKSL
SASTSSVSSS SSLGSLSTSS SKGSLSSGLS FTDIYDVNWP GSSVDMIDLH KRVERLLRSS
NDAISPQPSL SPRSSLSSVS PPVSPQLHKV PSKVSNYTFE SNNSIIYDKF QMSESNIQTV
TGNNPTTLVN SKYNDSADPL YQNIGINLVC LPPRYDDVER QRQLERSGKL LDNVKNKLLM
YDHNLENVRL CEDERAYPQS RISQTRQQLE PPLSPISETP QDQNFELIQV SSTPSSGSNT
RSVSAAVSDE SVAGDSGVFE AANRLQHCNL DTAQIQIKLR YAVSEGLLHV GIERARNLSA
LLIPQQSQVF IKTVLLPSGP GSGSCCTKTV TDLKKPIFGE NFPLSVALNK LSSKTLQINV
LCLTNSIEEC VGYAQVSLAD FSPESVSSKW YNILGSEFMQ LKSPTNKTLR NSSINVKNEG
NNKSEVNETR REESSDESTI ISSQASTLTR PAVVESCAST FCLAEEEEED VLEQVFPLED
ETCIDKETNT ECVFVLEKGN RGENKQMGII KRSQTFSPSA AQHQYTCRLN RSDSDSSMPL
YRRGAPFQRN SVERRSLRWK PSSGLTVVKV NSHRRSGRVP AVARTSLDLE LDRRAQLSRL
QAQQDELEKL RNLTTKLESV RARGDAELAA LVLEDQQFQT LIAQAETSLQ PQSQDDKRVE
KMFKKTAKEI YKLRKSKAGK GKPDVISFKE KMAFFTRVHL NIPNLPGEEI RSESSTLTRG
ESLLNPELED DDADDADADD DDNDNDNDDN DNKLELNESN EEGLSVIVSE TINESTGETL
RNVEGEEKKV VMENSEINIR SVDKDSRTVE GSEGIQSGKE NQRFEYVVDR ILGVEV
//
