ID E0VX48_PEDHC Unreviewed; 707 AA.
AC E0VX48;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Hemocyanin subunit, putative {ECO:0000313|EMBL:EEB17954.1, ECO:0000313|EnsemblMetazoa:PHUM494820-PA};
DE EC=1.14.18.1 {ECO:0000313|EMBL:EEB17954.1};
GN Name=8235989 {ECO:0000313|EnsemblMetazoa:PHUM494820-PA};
GN ORFNames=Phum_PHUM494820 {ECO:0000313|EMBL:EEB17954.1};
OS Pediculus humanus subsp. corporis (Body louse).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Paraneoptera; Psocodea; Phthiraptera; Anoplura; Pediculidae;
OC Pediculus.
OX NCBI_TaxID=121224;
RN [1] {ECO:0000313|EMBL:EEB17954.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB17954.1};
RA Kirkness E., Hannick L., Hass B., Bruggner R., Lawson D., Bidwell S.,
RA Joardar V., Caler E., Walenz B., Inman J., Schobel S., Galinsky K.,
RA Amedeo P., Strausberg R.;
RT "Annotation of Pediculus humanus corporis strain USDA.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EEB17954.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB17954.1};
RG The Human Body Louse Genome Consortium;
RA Kirkness E., Walenz B., Hass B., Bruggner R., Strausberg R.;
RT "The genome of the human body louse.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:PHUM494820-PA}
RP IDENTIFICATION.
RC STRAIN=USDA {ECO:0000313|EnsemblMetazoa:PHUM494820-PA};
RG EnsemblMetazoa;
RL Submitted (FEB-2021) to UniProtKB.
CC -!- SIMILARITY: Belongs to the hemocyanin family.
CC {ECO:0000256|ARBA:ARBA00038082}.
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DR EMBL; AAZO01005992; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS235829; EEB17954.1; -; Genomic_DNA.
DR RefSeq; XP_002430692.1; XM_002430647.1.
DR AlphaFoldDB; E0VX48; -.
DR STRING; 121224.E0VX48; -.
DR EnsemblMetazoa; PHUM494820-RA; PHUM494820-PA; PHUM494820.
DR GeneID; 8235989; -.
DR KEGG; phu:Phum_PHUM494820; -.
DR CTD; 8235989; -.
DR VEuPathDB; VectorBase:PHUM494820; -.
DR eggNOG; ENOG502QR98; Eukaryota.
DR HOGENOM; CLU_012213_1_0_1; -.
DR InParanoid; E0VX48; -.
DR OMA; SRYHMER; -.
DR OrthoDB; 5406463at2759; -.
DR Proteomes; UP000009046; Unassembled WGS sequence.
DR GO; GO:0045735; F:nutrient reservoir activity; IEA:UniProtKB-KW.
DR GO; GO:0004503; F:tyrosinase activity; IEA:UniProtKB-EC.
DR Gene3D; 1.10.1280.10; Di-copper center containing domain from catechol oxidase; 1.
DR Gene3D; 2.60.40.1520; Hemocyanin, C-terminal domain; 1.
DR Gene3D; 1.20.1370.10; Hemocyanin, N-terminal domain; 1.
DR InterPro; IPR008922; Di-copper_centre_dom_sf.
DR InterPro; IPR013788; Hemocyanin/hexamerin.
DR InterPro; IPR000896; Hemocyanin/hexamerin_mid_dom.
DR InterPro; IPR005203; Hemocyanin_C.
DR InterPro; IPR037020; Hemocyanin_C_sf.
DR InterPro; IPR005204; Hemocyanin_N.
DR InterPro; IPR036697; Hemocyanin_N_sf.
DR InterPro; IPR014756; Ig_E-set.
DR PANTHER; PTHR11511:SF5; FAT-BODY PROTEIN 1-RELATED; 1.
DR PANTHER; PTHR11511; LARVAL STORAGE PROTEIN/PHENOLOXIDASE; 1.
DR Pfam; PF03723; Hemocyanin_C; 1.
DR Pfam; PF00372; Hemocyanin_M; 1.
DR Pfam; PF03722; Hemocyanin_N; 1.
DR PRINTS; PR00187; HAEMOCYANIN.
DR SUPFAM; SSF48056; Di-copper centre-containing domain; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF48050; Hemocyanin, N-terminal domain; 1.
DR PROSITE; PS00209; HEMOCYANIN_1; 1.
DR PROSITE; PS00210; HEMOCYANIN_2; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000313|EMBL:EEB17954.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000009046};
KW Signal {ECO:0000256|SAM:SignalP};
KW Storage protein {ECO:0000256|ARBA:ARBA00022761}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..707
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5011412737"
FT DOMAIN 50..173
FT /note="Hemocyanin N-terminal"
FT /evidence="ECO:0000259|Pfam:PF03722"
FT DOMAIN 178..442
FT /note="Hemocyanin/hexamerin middle"
FT /evidence="ECO:0000259|Pfam:PF00372"
FT DOMAIN 452..697
FT /note="Hemocyanin C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03723"
SQ SEQUENCE 707 AA; 81911 MW; 267F0BFB45714E4B CRC64;
MSKFFVFLAC LVALAATAHV QHGTEKKIEE EDFETFFFFF FFFIIADKDF LSKQKAVLQL
LVHIHQPAVV PEIKEVATTF NWEQNVNNFN DVKTVENLIN LLKTGGILGR KNNFSPLYKT
HLRQAKSVFE VLYNAKDWKT FFNVASYLRE RVNYGLFVYA FSAAVLHRPD TQGVVLPPLY
EVCPHFYVNE KTIQKAYEAR MKISSMGTGK ESVVIPSNYT GWINLQNPEL RTSYFTEDVG
LNFYHFVHHL TYPQWLKQEY YGIKNERQGE LFYFTHQQLL ARYRLERHAN FMYPMKNFSF
GEPNVVAYAP KLRYFNGEAV PSRPENIKIR DYDLAEVERV KDYERRLRDA VDQGYVKTVK
GEKIPLTTET GIDVLGRLVQ KGITSVNPKY YGALYQLTLN LLGHVVDPYH QNNVAPSVLQ
HYETMLRDPM YYRLYQHVNR IFESYKKTLP VYTKETLQFP GVTVEKVEVD KLMTYFENFD
VDVTNAVVVG KVEDDKLLKI VVRQPRLNHK DFTYRVTVNS NQDTTALVHV FLAPKYDVTG
TRELSLAEKK QFMVQIDRFL YDLKNGKTVI ERNSKDSTVS VPDFTSFRVL SKKVEDALQG
KSQFYVNDKG QEYGFPRRLL LPKGTKSGTP YTLHVVVTPY KPTGTKEVVR GVKTYVTCGG
NVVCGDAHPL GYPFDREIVE REFNVPNIHV ADVTIYHKKL EDYSTDV
//
