ID E0VXG8_PEDHC Unreviewed; 590 AA.
AC E0VXG8;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Glucose dehydrogenase, putative {ECO:0000313|EMBL:EEB18074.1, ECO:0000313|EnsemblMetazoa:PHUM500400-PA};
DE EC=1.1.99.10 {ECO:0000313|EMBL:EEB18074.1};
GN Name=8236334 {ECO:0000313|EnsemblMetazoa:PHUM500400-PA};
GN ORFNames=Phum_PHUM500400 {ECO:0000313|EMBL:EEB18074.1};
OS Pediculus humanus subsp. corporis (Body louse).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Paraneoptera; Psocodea; Phthiraptera; Anoplura; Pediculidae;
OC Pediculus.
OX NCBI_TaxID=121224;
RN [1] {ECO:0000313|EMBL:EEB18074.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB18074.1};
RA Kirkness E., Hannick L., Hass B., Bruggner R., Lawson D., Bidwell S.,
RA Joardar V., Caler E., Walenz B., Inman J., Schobel S., Galinsky K.,
RA Amedeo P., Strausberg R.;
RT "Annotation of Pediculus humanus corporis strain USDA.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EEB18074.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB18074.1};
RG The Human Body Louse Genome Consortium;
RA Kirkness E., Walenz B., Hass B., Bruggner R., Strausberg R.;
RT "The genome of the human body louse.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:PHUM500400-PA}
RP IDENTIFICATION.
RC STRAIN=USDA {ECO:0000313|EnsemblMetazoa:PHUM500400-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|PIRSR:PIRSR000137-2};
CC -!- SIMILARITY: Belongs to the GMC oxidoreductase family.
CC {ECO:0000256|ARBA:ARBA00010790}.
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DR EMBL; AAZO01006067; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS235832; EEB18074.1; -; Genomic_DNA.
DR RefSeq; XP_002430812.1; XM_002430767.1.
DR AlphaFoldDB; E0VXG8; -.
DR STRING; 121224.E0VXG8; -.
DR EnsemblMetazoa; PHUM500400-RA; PHUM500400-PA; PHUM500400.
DR GeneID; 8236334; -.
DR KEGG; phu:Phum_PHUM500400; -.
DR CTD; 8236334; -.
DR VEuPathDB; VectorBase:PHUM500400; -.
DR eggNOG; KOG1238; Eukaryota.
DR HOGENOM; CLU_002865_7_0_1; -.
DR InParanoid; E0VXG8; -.
DR OMA; GINYMMY; -.
DR OrthoDB; 3382025at2759; -.
DR Proteomes; UP000009046; Unassembled WGS sequence.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR GO; GO:0016614; F:oxidoreductase activity, acting on CH-OH group of donors; IEA:InterPro.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR Gene3D; 3.30.560.10; Glucose Oxidase, domain 3; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR012132; GMC_OxRdtase.
DR InterPro; IPR000172; GMC_OxRdtase_N.
DR InterPro; IPR007867; GMC_OxRtase_C.
DR PANTHER; PTHR11552:SF154; FI04917P; 1.
DR PANTHER; PTHR11552; GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE; 1.
DR Pfam; PF05199; GMC_oxred_C; 1.
DR Pfam; PF00732; GMC_oxred_N; 1.
DR PIRSF; PIRSF000137; Alcohol_oxidase; 1.
DR SUPFAM; SSF54373; FAD-linked reductases, C-terminal domain; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR PROSITE; PS00624; GMC_OXRED_2; 1.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|PIRSR:PIRSR000137-2};
KW Flavoprotein {ECO:0000256|PIRSR:PIRSR000137-2};
KW Oxidoreductase {ECO:0000313|EMBL:EEB18074.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000009046}.
FT DOMAIN 257..271
FT /note="Glucose-methanol-choline oxidoreductase N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS00624"
FT BINDING 220
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR000137-2"
SQ SEQUENCE 590 AA; 65973 MW; 53BE614081FD507A CRC64;
MFDLLHIGGG SAGSIIAGRL SDNLNDATIL LIEAGGHGYD IFNIPFLGPL KQMSSIDWQY
TTIPQKNSCF ALENNVSKWP SGKILGGSTH LNYMIHLEGD VNDYKSWKDP HSNDWDENDI
NYYFTKSKKC FSNRQCKFKI DKGSVNVRNS IHSTKLSDAI LDAAKELGYS LNDLNSKTST
GFMKPFLNIN EMGMRWTSDQ YLKGVMTKRK NVKILTHAIV EKILLLNNYE AYGVSVRTIC
GQSLTIHANL EIIVSAGTIG SPKLLMLSGI GPKNSLHESN ISSKVDLPVG KNLKDHLTTG
LDLVILDKHL FSYVDLMLPS SAYEFFARGK GPFTSGLVDV VGVVRSSLMG KFDGKNTSPD
LEFMVMMAGV SSDQGVFMRK SMGISQKVWE NYFKFFTNES VVSILPVLLH PKSVGEMNLN
PNDPNGMPLI DPKYLSHEND VFTLVEGIRT IRKITKTKSL ADFGVRFNDK KFPGCENWKF
DSDEYWRCYV KHLTLTVYHP VGTCKMSEMG IDGVVDYNLR VHKTNKLRVI DASIMPTLPS
SNPNAVVIMI AEKGSDMIIE NHNNRFSSCS IRDMFITPKV CQIRRMSTTI
//
