ID E0VZN3_PEDHC Unreviewed; 938 AA.
AC E0VZN3;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=Glutamate receptor, ionotropic kainate 2, putative {ECO:0000313|EMBL:EEB18839.1};
GN Name=8235322 {ECO:0000313|EnsemblMetazoa:PHUM536820-PA};
GN ORFNames=Phum_PHUM536820 {ECO:0000313|EMBL:EEB18839.1};
OS Pediculus humanus subsp. corporis (Body louse).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Paraneoptera; Psocodea; Phthiraptera; Anoplura; Pediculidae;
OC Pediculus.
OX NCBI_TaxID=121224;
RN [1] {ECO:0000313|EMBL:EEB18839.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB18839.1};
RA Kirkness E., Hannick L., Hass B., Bruggner R., Lawson D., Bidwell S.,
RA Joardar V., Caler E., Walenz B., Inman J., Schobel S., Galinsky K.,
RA Amedeo P., Strausberg R.;
RT "Annotation of Pediculus humanus corporis strain USDA.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EEB18839.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB18839.1};
RG The Human Body Louse Genome Consortium;
RA Kirkness E., Walenz B., Hass B., Bruggner R., Strausberg R.;
RT "The genome of the human body louse.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:PHUM536820-PA}
RP IDENTIFICATION.
RC STRAIN=USDA {ECO:0000313|EnsemblMetazoa:PHUM536820-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10.1)
CC family. {ECO:0000256|ARBA:ARBA00008685}.
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DR EMBL; AAZO01006521; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAZO01006522; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS235853; EEB18839.1; -; Genomic_DNA.
DR RefSeq; XP_002431577.1; XM_002431532.1.
DR AlphaFoldDB; E0VZN3; -.
DR EnsemblMetazoa; PHUM536820-RA; PHUM536820-PA; PHUM536820.
DR GeneID; 8235322; -.
DR KEGG; phu:Phum_PHUM536820; -.
DR CTD; 8235322; -.
DR VEuPathDB; VectorBase:PHUM536820; -.
DR eggNOG; KOG1052; Eukaryota.
DR HOGENOM; CLU_007257_1_1_1; -.
DR InParanoid; E0VZN3; -.
DR OMA; ENYHYIF; -.
DR OrthoDB; 1011589at2759; -.
DR Proteomes; UP000009046; Unassembled WGS sequence.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-KW.
DR GO; GO:0015276; F:ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:UniProt.
DR CDD; cd06382; PBP1_iGluR_Kainate; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 2.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR019594; Glu/Gly-bd.
DR InterPro; IPR001508; Iono_Glu_rcpt_met.
DR InterPro; IPR015683; Ionotropic_Glu_rcpt.
DR InterPro; IPR001320; Iontro_rcpt_C.
DR InterPro; IPR028082; Peripla_BP_I.
DR InterPro; IPR001638; Solute-binding_3/MltF_N.
DR PANTHER; PTHR18966:SF599; FI01405P; 1.
DR PANTHER; PTHR18966; IONOTROPIC GLUTAMATE RECEPTOR; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF00060; Lig_chan; 1.
DR Pfam; PF10613; Lig_chan-Glu_bd; 1.
DR Pfam; PF00497; SBP_bac_3; 1.
DR PRINTS; PR00177; NMDARECEPTOR.
DR SMART; SM00918; Lig_chan-Glu_bd; 1.
DR SMART; SM00079; PBPe; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00023257};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:EEB18839.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000009046};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 542..561
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 618..640
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 804..828
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 412..780
FT /note="Ionotropic glutamate receptor C-terminal"
FT /evidence="ECO:0000259|SMART:SM00079"
FT DOMAIN 422..486
FT /note="Ionotropic glutamate receptor L-glutamate and
FT glycine-binding"
FT /evidence="ECO:0000259|SMART:SM00918"
SQ SEQUENCE 938 AA; 107042 MW; ED97F10DC888AEDB CRC64;
MFGKGIVRVT NKKKKSRTGY GSSGTCLSIR SAIFTEDQKE TSTELAFKYA VYKINKNKNF
LPNTTLVYDI QYVPRDDSFR TSKKACRQLE NGIQAIFGPT DPLLGAHIQS ICEALDVPHM
EARLDFEPFL KEFSINLHPS QQHLNKAFQD LMIFLNWTKV AIIYEEDYGL FKLQDLVKSP
PNSKMEMYIR QANPTTYRHV LKEIRQKEIY KLLVDTNPVH TNVFFRAILQ LQMNDYRYHY
MFTTFDIETF DLEDFKYNSV NITAFRLVDV EDANVYNVLQ QMEKFQPVGQ AILNSSGIIQ
VEPALMYDAV HVFASGLSAM DKSYSVKPAN LSCDLEKPWE NGANLFNFIN SVYINGLTGR
VEFKEGKRSN FKLDLLKLKK EKLQKVGQWN PFSGINITDP NAFYETNTNN ITLVVMTREE
RPYVMVRHDK NLTGNARFEG FCIDLLRWIS GQVGFNYEIR LVPDHKYGVL DQETKQWNGI
VRELMDKRAD LAVASITINY ARESVIDFTK PFMNLGIGIL FKVPTSQPTR LFSFMNPLAV
EIWIYVLAAY ILVSFTLFVM ARFSPYEWHN PHPCQTDSDI IENQFSVSNS FWFITGTFLR
QGSGLNPKAA STRIVGGIWW FFTLIIISSY TANLAAFLTV ERMITPIENA ADLAEQTEIS
YGTLEGGSTM TFFRDSKIGI YQKMWRFMES KKPSVFVPSY DEGVKRVLDG NYAFLMESTM
LDYVVQRDCN LTQIGGLLDS KGYGIATPKG SPWRDRISLA ILELQEKGIT QILYDKWWKN
TGDVCNRDDK SKESKANALG IENIGGVFVV LLCGLALAVI VAFLEFCWNS KKNARMDQQS
LCSEMAEELR FAMRCHGSKQ KPALRRSCAK CSPLTTYVPA PLDMPHINGL PDFLINWSFS
KSENATTTGN TISDSCDETE LDQSNIVTID TLMKETEM
//
