ID E0W0I6_PEDHC Unreviewed; 285 AA.
AC E0W0I6;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2010, sequence version 1.
DT 24-JAN-2024, entry version 56.
DE SubName: Full=Lactoylglutathione lyase, putative {ECO:0000313|EMBL:EEB19142.1, ECO:0000313|EnsemblMetazoa:PHUM556400-PA};
GN Name=8234661 {ECO:0000313|EnsemblMetazoa:PHUM556400-PA};
GN ORFNames=Phum_PHUM556400 {ECO:0000313|EMBL:EEB19142.1};
OS Pediculus humanus subsp. corporis (Body louse).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Paraneoptera; Psocodea; Phthiraptera; Anoplura; Pediculidae;
OC Pediculus.
OX NCBI_TaxID=121224;
RN [1] {ECO:0000313|EMBL:EEB19142.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB19142.1};
RA Kirkness E., Hannick L., Hass B., Bruggner R., Lawson D., Bidwell S.,
RA Joardar V., Caler E., Walenz B., Inman J., Schobel S., Galinsky K.,
RA Amedeo P., Strausberg R.;
RT "Annotation of Pediculus humanus corporis strain USDA.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EEB19142.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB19142.1};
RG The Human Body Louse Genome Consortium;
RA Kirkness E., Walenz B., Hass B., Bruggner R., Strausberg R.;
RT "The genome of the human body louse.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:PHUM556400-PA}
RP IDENTIFICATION.
RC STRAIN=USDA {ECO:0000313|EnsemblMetazoa:PHUM556400-PA};
RG EnsemblMetazoa;
RL Submitted (FEB-2021) to UniProtKB.
CC -!- SIMILARITY: Belongs to the glyoxalase I family.
CC {ECO:0000256|ARBA:ARBA00010363}.
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DR EMBL; AAZO01006763; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS235860; EEB19142.1; -; Genomic_DNA.
DR RefSeq; XP_002431880.1; XM_002431835.1.
DR AlphaFoldDB; E0W0I6; -.
DR STRING; 121224.E0W0I6; -.
DR EnsemblMetazoa; PHUM556400-RA; PHUM556400-PA; PHUM556400.
DR GeneID; 8234661; -.
DR KEGG; phu:Phum_PHUM556400; -.
DR CTD; 8234661; -.
DR VEuPathDB; VectorBase:PHUM556400; -.
DR eggNOG; KOG2943; Eukaryota.
DR HOGENOM; CLU_044479_0_0_1; -.
DR InParanoid; E0W0I6; -.
DR OMA; GCEAACN; -.
DR OrthoDB; 103756at2759; -.
DR Proteomes; UP000009046; Unassembled WGS sequence.
DR GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR CDD; cd16357; GLOD4_C; 1.
DR CDD; cd08358; GLOD4_N; 1.
DR Gene3D; 3.10.180.10; 2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1; 2.
DR InterPro; IPR043193; GLOD4.
DR InterPro; IPR043194; GLOD4_C.
DR InterPro; IPR029068; Glyas_Bleomycin-R_OHBP_Dase.
DR InterPro; IPR037523; VOC.
DR PANTHER; PTHR46466; GLYOXALASE DOMAIN-CONTAINING PROTEIN 4; 1.
DR PANTHER; PTHR46466:SF1; GLYOXALASE DOMAIN-CONTAINING PROTEIN 4; 1.
DR Pfam; PF21701; GLOD4_C; 1.
DR Pfam; PF21207; GLOD4_N; 1.
DR SUPFAM; SSF54593; Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase; 2.
DR PROSITE; PS51819; VOC; 2.
PE 3: Inferred from homology;
KW Lyase {ECO:0000313|EMBL:EEB19142.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000009046};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 8..132
FT /note="VOC"
FT /evidence="ECO:0000259|PROSITE:PS51819"
FT DOMAIN 140..259
FT /note="VOC"
FT /evidence="ECO:0000259|PROSITE:PS51819"
SQ SEQUENCE 285 AA; 32043 MW; CDF901CA5427C0C4 CRC64;
MALSLNGRAL HFVFKVADRA ATARFYRDLL GMKVLRHEEF KEGCEAACNG LYDNRWSKTM
IGYGPEDSHF VIELTYNYGV KSYEKGNDFL GITIRSSEII KRAKEMNWAM EEAHGNFVLE
APGGYKYNII NEPQPQNKDP VEKVTLASSN LEKTVKYWNG ILGMKIINKT DKTVSFSFGE
NQCVLEFKDI GGPVNHALAY GRIAFSVPKA SLPAIQSRME SEKQTILKPL ISLDTPGKAT
VTVVILADPD NHEICFVDDE SFRQLSQVDP KGDADLNKYM RVDRS
//
