ID E0W189_PEDHC Unreviewed; 514 AA.
AC E0W189;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Arylsulfatase B, putative {ECO:0000313|EMBL:EEB19395.1};
DE EC=3.1.6.12 {ECO:0000313|EMBL:EEB19395.1};
GN Name=8234914 {ECO:0000313|EnsemblMetazoa:PHUM570670-PA};
GN ORFNames=Phum_PHUM570670 {ECO:0000313|EMBL:EEB19395.1};
OS Pediculus humanus subsp. corporis (Body louse).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Paraneoptera; Psocodea; Phthiraptera; Anoplura; Pediculidae;
OC Pediculus.
OX NCBI_TaxID=121224;
RN [1] {ECO:0000313|EMBL:EEB19395.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB19395.1};
RA Kirkness E., Hannick L., Hass B., Bruggner R., Lawson D., Bidwell S.,
RA Joardar V., Caler E., Walenz B., Inman J., Schobel S., Galinsky K.,
RA Amedeo P., Strausberg R.;
RT "Annotation of Pediculus humanus corporis strain USDA.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EEB19395.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB19395.1};
RG The Human Body Louse Genome Consortium;
RA Kirkness E., Walenz B., Hass B., Bruggner R., Strausberg R.;
RT "The genome of the human body louse.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:PHUM570670-PA}
RP IDENTIFICATION.
RC STRAIN=USDA {ECO:0000313|EnsemblMetazoa:PHUM570670-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- COFACTOR:
CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|ARBA:ARBA00001913};
CC -!- SIMILARITY: Belongs to the sulfatase family.
CC {ECO:0000256|ARBA:ARBA00008779}.
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DR EMBL; AAZO01006931; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS235866; EEB19395.1; -; Genomic_DNA.
DR RefSeq; XP_002432133.1; XM_002432088.1.
DR AlphaFoldDB; E0W189; -.
DR STRING; 121224.E0W189; -.
DR EnsemblMetazoa; PHUM570670-RA; PHUM570670-PA; PHUM570670.
DR GeneID; 8234914; -.
DR KEGG; phu:Phum_PHUM570670; -.
DR CTD; 8234914; -.
DR VEuPathDB; VectorBase:PHUM570670; -.
DR eggNOG; KOG3867; Eukaryota.
DR HOGENOM; CLU_006332_10_1_1; -.
DR InParanoid; E0W189; -.
DR OMA; PWINTEM; -.
DR OrthoDB; 2913702at2759; -.
DR Proteomes; UP000009046; Unassembled WGS sequence.
DR GO; GO:0003943; F:N-acetylgalactosamine-4-sulfatase activity; IEA:UniProtKB-EC.
DR CDD; cd16029; 4-S; 1.
DR Gene3D; 3.30.1120.10; -; 1.
DR Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 1.
DR InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR InterPro; IPR047115; ARSB.
DR InterPro; IPR024607; Sulfatase_CS.
DR InterPro; IPR000917; Sulfatase_N.
DR PANTHER; PTHR10342; ARYLSULFATASE; 1.
DR PANTHER; PTHR10342:SF273; RE14504P; 1.
DR Pfam; PF00884; Sulfatase; 1.
DR SUPFAM; SSF53649; Alkaline phosphatase-like; 1.
DR PROSITE; PS00523; SULFATASE_1; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:EEB19395.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000009046}.
FT DOMAIN 31..352
FT /note="Sulfatase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00884"
SQ SEQUENCE 514 AA; 58488 MW; 4962CA9EF4F138AF CRC64;
MFTIIIIIIG YYLTLCTWID IINCEKLVNN PHIIIILADD LGWNDVGFHG SNQIPTPNID
ALAFTGIILN NYYVAPVCTP SRSALLTGKY PIHTGLQHGV IHGSAPYGLN LNEKLLPEYL
RSLNYVTRHV GKWHLGSFKK DYTPEYRGFD SHYGYWTGHQ DYYDHTAIEN PGFWGYDMRR
GMNVTRSDFG YYTTDLFTNE AVKVIKGHDS NKPLFLYLAH LATHSGNKYS PLQAPAETVA
KFNYIKDKNR RLFAGMLSKL DESVGKVVEA LADSNMINNC VILFSTDNGG PAGGFNLNAA
SNWPLRGVKD TLWEGGVRGV GFIWSPFLPS SKVSNAMIHI TDWLPTLLSL TNASNSISDI
DGINVWPNLS KGLPSVRKEI LLNIDTERKI AALRYKNWKY KKGNANNWNK WYGPSGRDMN
YDWNELYNSD AAKAIKHIKV LPNKKLVMEL INATQVTCNV KEEEEEEDES DQNSCERVIW
HQISKMVPPR NKPVDIRSNP VYWDYTWTNW MDYL
//
