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Database: UniProt
Entry: E0W1R2_PEDHC
LinkDB: E0W1R2_PEDHC
Original site: E0W1R2_PEDHC 
ID   E0W1R2_PEDHC            Unreviewed;      1055 AA.
AC   E0W1R2;
DT   02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2010, sequence version 1.
DT   25-OCT-2017, entry version 50.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EEB19644.1, ECO:0000313|VectorBase:PHUM581890-PA};
GN   Name=8232391 {ECO:0000313|VectorBase:PHUM581890-PA};
GN   ORFNames=Phum_PHUM581890 {ECO:0000313|EMBL:EEB19644.1};
OS   Pediculus humanus subsp. corporis (Body louse).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Paraneoptera; Psocodea; Phthiraptera; Anoplura;
OC   Pediculidae; Pediculus.
OX   NCBI_TaxID=121224 {ECO:0000313|Proteomes:UP000009046};
RN   [1] {ECO:0000313|EMBL:EEB19644.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=USDA {ECO:0000313|EMBL:EEB19644.1};
RA   Kirkness E., Hannick L., Hass B., Bruggner R., Lawson D., Bidwell S.,
RA   Joardar V., Caler E., Walenz B., Inman J., Schobel S., Galinsky K.,
RA   Amedeo P., Strausberg R.;
RT   "Annotation of Pediculus humanus corporis strain USDA.";
RL   Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:EEB19644.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=USDA {ECO:0000313|EMBL:EEB19644.1};
RG   The Human Body Louse Genome Consortium;
RA   Kirkness E., Walenz B., Hass B., Bruggner R., Strausberg R.;
RT   "The genome of the human body louse.";
RL   Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Proteomes:UP000009046, ECO:0000313|VectorBase:PHUM581890-PA}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=USDA {ECO:0000313|Proteomes:UP000009046,
RC   ECO:0000313|VectorBase:PHUM581890-PA};
RX   PubMed=20566863; DOI=10.1073/pnas.1003379107;
RA   Kirkness E.F., Haas B.J., Sun W., Braig H.R., Perotti M.A.,
RA   Clark J.M., Lee S.H., Robertson H.M., Kennedy R.C., Elhaik E.,
RA   Gerlach D., Kriventseva E.V., Elsik C.G., Graur D., Hill C.A.,
RA   Veenstra J.A., Walenz B., Tubio J.M., Ribeiro J.M., Rozas J.,
RA   Johnston J.S., Reese J.T., Popadic A., Tojo M., Raoult D., Reed D.L.,
RA   Tomoyasu Y., Krause E., Mittapalli O., Margam V.M., Li H.M.,
RA   Meyer J.M., Johnson R.M., Romero-Severson J., Vanzee J.P.,
RA   Alvarez-Ponce D., Vieira F.G., Aguade M., Guirao-Rico S., Anzola J.M.,
RA   Yoon K.S., Strycharz J.P., Unger M.F., Christley S., Lobo N.F.,
RA   Seufferheld M.J., Wang N., Dasch G.A., Struchiner C.J., Madey G.,
RA   Hannick L.I., Bidwell S., Joardar V., Caler E., Shao R., Barker S.C.,
RA   Cameron S., Bruggner R.V., Regier A., Johnson J., Viswanathan L.,
RA   Utterback T.R., Sutton G.G., Lawson D., Waterhouse R.M., Venter J.C.,
RA   Strausberg R.L., Berenbaum M.R., Collins F.H., Zdobnov E.M.,
RA   Pittendrigh B.R.;
RT   "Genome sequences of the human body louse and its primary endosymbiont
RT   provide insights into the permanent parasitic lifestyle.";
RL   Proc. Natl. Acad. Sci. U.S.A. 107:12168-12173(2010).
RN   [4] {ECO:0000313|VectorBase:PHUM581890-PA}
RP   IDENTIFICATION.
RC   STRAIN=USDA {ECO:0000313|VectorBase:PHUM581890-PA};
RG   VectorBase;
RL   Submitted (FEB-2017) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the transient receptor (TC 1.A.4) family.
CC       {ECO:0000256|SAAS:SAAS00933551}.
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DR   EMBL; DS235873; EEB19644.1; -; Genomic_DNA.
DR   RefSeq; XP_002432382.1; XM_002432337.1.
DR   STRING; 121225.PHUM581890-PA; -.
DR   EnsemblMetazoa; PHUM581890-RA; PHUM581890-PA; PHUM581890.
DR   GeneID; 8232391; -.
DR   KEGG; phu:Phum_PHUM581890; -.
DR   VectorBase; PHUM581890-RA; PHUM581890-PA; PHUM581890.
DR   CTD; 8232391; -.
DR   InParanoid; E0W1R2; -.
DR   KO; K04975; -.
DR   OMA; SEKEWVK; -.
DR   PhylomeDB; E0W1R2; -.
DR   Proteomes; UP000009046; Partially assembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005216; F:ion channel activity; IEA:InterPro.
DR   CDD; cd00204; ANK; 1.
DR   Gene3D; 1.25.40.20; -; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR020683; Ankyrin_rpt-contain_dom.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR024862; TRPV.
DR   PANTHER; PTHR10582; PTHR10582; 1.
DR   Pfam; PF00023; Ank; 1.
DR   Pfam; PF12796; Ank_2; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   SMART; SM00248; ANK; 5.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 2.
PE   3: Inferred from homology;
KW   ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023,
KW   ECO:0000256|SAAS:SAAS00933366};
KW   Complete proteome {ECO:0000313|Proteomes:UP000009046};
KW   Ion channel {ECO:0000256|SAAS:SAAS00931870};
KW   Ion transport {ECO:0000256|SAAS:SAAS00929079};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009046};
KW   Repeat {ECO:0000256|SAAS:SAAS00931009};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|SAAS:SAAS00927442}.
FT   TRANSMEM    468    488       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    508    529       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    536    558       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    603    625       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      168    320       ANK_REP_REGION. {ECO:0000259|PROSITE:
FT                                PS50297}.
FT   REPEAT      168    200       ANK. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00023}.
FT   REPEAT      226    258       ANK. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00023}.
SQ   SEQUENCE   1055 AA;  117777 MW;  163914B23B1071BD CRC64;
     MGAGLCGTSQ DPQNQGSVLD RVISQASNKD DCLLYKLANY KNSGELIEAY NIGGQAEVEK
     LIKEQFGVLM YADGKGEVIK RAEYLRWKFR DQAQVVLPIE ASLSIYDPLA KWEDHEACWQ
     MQYRGSLGET LLHVLIICDS KIHTKLARTL LKCFPKLALD IVEGEEYLGA SALHLAIAYN
     NNELVEDLVD AGANINQRAV GSFFLPKDQQ RAKPLKTTDY EGLAYLGEYP LSWAACCSNE
     SVYNLLLDVG ADPDSQDSFG NMILHMVVVC DKLDMFGYAL RHPKVPASNG IINNEGLTPL
     TLACKLGRAD VFKEMLELSA KEFWRYSNIT CSAYPLNALD TLLPDGRTNW NSAIFIILNG
     TKEEHLDMLD GGIIQRLLEE KWKTFARNQF LKRLVIFFLH IFCLSGSVYL RPDDRNKPLL
     GGTSVQDVVR YCFEIGTILG VLCYLCFQQG DEIRNQGLIS FLKQLPHDPA KFIFLISNLL
     ILACIPYRVA GDTDTEEAIL VFAVPSSWFL LMFFAGAIRL TGPFVTMIYS MITGDMLTFG
     IIYSVFLFGF SQSFFFLYKG SKNVSSSLFT SYPSTWMALF QVTMGDYNYN DLSLTAYPAI
     SKMVFTIFMV LVPILLLNML IAMMGNTYAH VIEQSEKEWM KQWAKIVVAL ERAVNQEDCH
     RYLQEYSIKL GPGDDPSTEQ RGVLVIKSKS KTRAKQRKGA LCNWKRVGKV TIRELHKRGM
     TGEQLRRLMW GRSSISTPVK PAPIKLGHVT SISGVADITV PETTGNTVGT GGGGLLAALD
     VMAFTNDLEF SSENQTSTSF KTQPQPSEVS CVESDSNSDP LYNDPLRQLN EELNKTREEI
     LTLARVAANN DGIEEIPPQI CQYGWINNYN FFGNTFAQNQ KVEDPVQQPT FQSTPNHSDS
     DGLGDGLLLG SNRRLKRTRS ANIKRKFSGS STNEKNLLEP EDSSSTNSED FSCLTENYIN
     KNIKVNANFS ENSLRSNRSS ANLVVKKFGR RSGLKSSTNR IAPADLSPVG NVSKYSETLC
     NSYCITSSSD VLYQWSIKGI TNMNTLLGLE NEDSM
//
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