ID E0W452_PEDHC Unreviewed; 586 AA.
AC E0W452;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2010, sequence version 1.
DT 24-JAN-2024, entry version 60.
DE SubName: Full=Rac GTPase-activating protein, putative {ECO:0000313|EMBL:EEB20408.1, ECO:0000313|EnsemblMetazoa:PHUM615410-PA};
GN Name=8239807 {ECO:0000313|EnsemblMetazoa:PHUM615410-PA};
GN ORFNames=Phum_PHUM615410 {ECO:0000313|EMBL:EEB20408.1};
OS Pediculus humanus subsp. corporis (Body louse).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Paraneoptera; Psocodea; Phthiraptera; Anoplura; Pediculidae;
OC Pediculus.
OX NCBI_TaxID=121224;
RN [1] {ECO:0000313|EMBL:EEB20408.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB20408.1};
RA Kirkness E., Hannick L., Hass B., Bruggner R., Lawson D., Bidwell S.,
RA Joardar V., Caler E., Walenz B., Inman J., Schobel S., Galinsky K.,
RA Amedeo P., Strausberg R.;
RT "Annotation of Pediculus humanus corporis strain USDA.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EEB20408.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB20408.1};
RG The Human Body Louse Genome Consortium;
RA Kirkness E., Walenz B., Hass B., Bruggner R., Strausberg R.;
RT "The genome of the human body louse.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:PHUM615410-PA}
RP IDENTIFICATION.
RC STRAIN=USDA {ECO:0000313|EnsemblMetazoa:PHUM615410-PA};
RG EnsemblMetazoa;
RL Submitted (FEB-2021) to UniProtKB.
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DR EMBL; AAZO01007525; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS235886; EEB20408.1; -; Genomic_DNA.
DR RefSeq; XP_002433146.1; XM_002433101.1.
DR AlphaFoldDB; E0W452; -.
DR STRING; 121224.E0W452; -.
DR EnsemblMetazoa; PHUM615410-RA; PHUM615410-PA; PHUM615410.
DR GeneID; 8239807; -.
DR KEGG; phu:Phum_PHUM615410; -.
DR CTD; 8239807; -.
DR VEuPathDB; VectorBase:PHUM615410; -.
DR eggNOG; KOG3564; Eukaryota.
DR HOGENOM; CLU_026187_1_0_1; -.
DR InParanoid; E0W452; -.
DR OMA; ECKMPIS; -.
DR OrthoDB; 22770at2759; -.
DR Proteomes; UP000009046; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd20821; C1_MgcRacGAP; 1.
DR CDD; cd04382; RhoGAP_MgcRacGAP; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR46199:SF3; FI24033P1-RELATED; 1.
DR PANTHER; PTHR46199; RAC GTPASE-ACTIVATING PROTEIN 1; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000009046};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 292..342
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 355..544
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT COILED 50..105
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 586 AA; 67004 MW; 51305DD79BDE83B3 CRC64;
MTWESSLLWL LDEYRQSISF LQNDCTEEFL TFVIHQEQCR LKWKESVLEC QRLKSDIDLC
NEKLQDYEKK LNRARCLLDA EKKKRLKAES ERDELQEQVT QIEEILSTVR CAGDKLANET
KEKLDKFLST THSKLKPNTD TLGYQLNTID EINSTGSLLS DLSYTRSEDF DYEPQTEKPR
SRKLLRSTSP DINEFQINKK RKSAWSQNQV NKIEKVSSEQ LIATTTVTVP KQGPIVACST
IETYPQAYYK DTKPSAPPKL SSDTDSEVTE AINCFSHNSN PIYSKNKLFN RIHCFRNKTN
LKPSEECSVC VKKITFGNKM FYCSDCRVMV HPECRDKAPM PCLAIVATPR GTSGTTIADF
CSRTPPMVPP LIVHCVFEVE ARGLGEVGIY RIPGSEKDVR ALKDRFLRGK GVCSLSGYDI
HVVCGTIKDF LRSLSEPLVT FSLWPEFIRA SENEDVSERT SALYQAVSQL PQPNRDTLAF
MMQHLQKVSQ SPDCKMSKSN LAKVFGPTIV GYSRIEPVRN EMYVETAQQS QVIECLLDMP
GEYWYNFVNN EPDENIQPST PVLSLDYRRL NRNKNRKVFN TPPVAK
//
