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Database: UniProt
Entry: E0WSK5_9ENTR
LinkDB: E0WSK5_9ENTR
Original site: E0WSK5_9ENTR 
ID   E0WSK5_9ENTR            Unreviewed;       254 AA.
AC   E0WSK5;
DT   02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2010, sequence version 1.
DT   07-JUN-2017, entry version 38.
DE   RecName: Full=DnaA regulatory inactivator Hda {ECO:0000256|HAMAP-Rule:MF_01158, ECO:0000256|SAAS:SAAS00634471};
GN   Name=hda {ECO:0000256|HAMAP-Rule:MF_01158,
GN   ECO:0000313|EMBL:EFL91974.1};
GN   ORFNames=REG_0932 {ECO:0000313|EMBL:EFL91974.1};
OS   Candidatus Regiella insecticola LSR1.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; aphid secondary symbionts; Candidatus Regiella.
OX   NCBI_TaxID=663321 {ECO:0000313|EMBL:EFL91974.1, ECO:0000313|Proteomes:UP000005726};
RN   [1] {ECO:0000313|EMBL:EFL91974.1, ECO:0000313|Proteomes:UP000005726}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LSR1 {ECO:0000313|EMBL:EFL91974.1};
RX   PubMed=19840097;
RA   Degnan P.H., Leonardo T.E., Cass B.N., Hurwitz B., Stern D.,
RA   Gibbs R.A., Richards S., Moran N.A.;
RT   "Dynamics of genome evolution in facultative symbionts of aphids.";
RL   Environ. Microbiol. 0:0-0(2009).
CC   -!- FUNCTION: Mediates the interaction of DNA replication inititator
CC       protein DnaA with DNA polymerase subunit beta sliding clamp
CC       (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering
CC       DnaA inactive for reinititation, a process called regulatory
CC       inhibition of DnaA or RIDA. {ECO:0000256|HAMAP-Rule:MF_01158}.
CC   -!- SUBUNIT: The active form seems to be an ADP-bound monomer. Forms
CC       the RIDA complex (regulatory inactivation of DnaA) of ATP-DnaA,
CC       ADP-Hda and the DNA-loaded beta sliding clamp (dnaN).
CC       {ECO:0000256|HAMAP-Rule:MF_01158}.
CC   -!- SIMILARITY: Belongs to the DnaA family. HdA subfamily.
CC       {ECO:0000256|HAMAP-Rule:MF_01158, ECO:0000256|SAAS:SAAS00548763}.
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DR   EMBL; GL379591; EFL91974.1; -; Genomic_DNA.
DR   STRING; 663321.REG_0932; -.
DR   EnsemblBacteria; EFL91974; EFL91974; REG_0932.
DR   eggNOG; ENOG4108KZ1; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   OrthoDB; POG091H0GIW; -.
DR   Proteomes; UP000005726; Unassembled WGS sequence.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-HAMAP.
DR   GO; GO:0032297; P:negative regulation of DNA-dependent DNA replication initiation; IEA:InterPro.
DR   HAMAP; MF_01158; Hda; 1.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR017788; Hda.
DR   InterPro; IPR022864; Hda_Enterobact.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   PRINTS; PR00051; DNAA.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR03420; DnaA_homol_Hda; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005726};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_01158,
KW   ECO:0000256|SAAS:SAAS00634466};
KW   DNA replication inhibitor {ECO:0000256|HAMAP-Rule:MF_01158,
KW   ECO:0000256|SAAS:SAAS00634468};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005726}.
FT   DOMAIN       37    233       Bac_DnaA. {ECO:0000259|Pfam:PF00308}.
SQ   SEQUENCE   254 AA;  28865 MW;  A105132B53B67F49 CRC64;
     MLKLQGFLAY FGSVLILIEV FLNSPAQLSL PLYLPDDETF ASFYPGENAS VLAAIQSVIH
     HSHGSYIYFW SGEGGGRSHL LHAACTEFSQ RGEAVGYVPL EKRAYFVEEV LDGMEQLALV
     CIDNIECVAG IPQWEMAIFN LYNRIQETGH TRLLITGDRP PRQLNLHLPD LASRLDWGQI
     YKLQPLSDDE KLQALQLRAK LRAFELPEDV GRFMLKRLDR KMRTLFMTLD QLDRASITAQ
     RKLTIPFVKE ILGL
//
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