ID E0XJ19_9NIDO Unreviewed; 272 AA.
AC E0XJ19;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2010, sequence version 1.
DT 28-JUN-2023, entry version 29.
DE RecName: Full=Replicase polyprotein 1ab {ECO:0000256|ARBA:ARBA00022087};
DE AltName: Full=ORF1ab polyprotein {ECO:0000256|ARBA:ARBA00029611};
DE Flags: Fragment;
OS Bat coronavirus BM48-39/BGR/2008.
OC Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC Nidovirales; Cornidovirineae; Coronaviridae; Coronavirinae.
OX NCBI_TaxID=864600 {ECO:0000313|EMBL:ADK66867.1};
RN [1] {ECO:0000313|EMBL:ADK66867.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=BtCoV/BM48-39/BGR/2008 {ECO:0000313|EMBL:ADK66867.1};
RX PubMed=20686038; DOI=10.1128/JVI.00650-10;
RA Drexler J.F., Gloza-Rausch F., Glende J., Corman V.M., Muth D.,
RA Goettsche M., Seebens A., Niedrig M., Pfefferle S., Yordanov S.,
RA Zhelyazkov L., Hermanns U., Vallo P., Lukashev A., Muller M.A., Deng H.,
RA Herrler G., Drosten C.;
RT "Genomic characterization of severe acute respiratory syndrome-related
RT coronavirus in European bats and classification of coronaviruses based on
RT partial RNA-dependent RNA polymerase gene sequences.";
RL J. Virol. 84:11336-11349(2010).
CC -!- SIMILARITY: Belongs to the coronaviruses polyprotein 1ab family.
CC {ECO:0000256|ARBA:ARBA00008087}.
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DR EMBL; GU190234; ADK66867.1; -; Genomic_RNA.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003968; F:RNA-dependent RNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR046441; RdRp_CoV.
DR InterPro; IPR001205; RNA-dir_pol_C.
DR Pfam; PF00680; RdRP_1; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS51948; COV_NSP12_RDRP; 1.
PE 3: Inferred from homology;
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW RNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022484,
KW ECO:0000313|EMBL:ADK66867.1}; Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1..272
FT /note="Nsp12 RNA-dependent RNA polymerase"
FT /evidence="ECO:0000259|PROSITE:PS51948"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ADK66867.1"
FT NON_TER 272
FT /evidence="ECO:0000313|EMBL:ADK66867.1"
SQ SEQUENCE 272 AA; 30440 MW; 0E05C0626A80DB52 CRC64;
VTYKLVSRYF EIYEGGCITA REVVVTNLNK SAGYPLNKFG KAGLYYESLS YEEQDALYAI
TKRNVLPTMT QLNLKYAISG KERARTVGGV SLLSTMTTRQ YHQKHLKSIV NTRNASVVIG
TTKFYGGWDN MLKTLIDGVE NPCLMGWDYP KCDRALPNMI RMISAMILGS KHTTCCDTSE
RYYRLCNELA QVLTEVVYSN GGFYLKPGGT TSGDATTAYA NSVFNIFQAV SANINRLLSI
DSNVCNNVNV KSLQRELYDN CYRSSHVDDA FV
//
