ID E0ZNK1_MICMN Unreviewed; 784 AA.
AC E0ZNK1;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE RecName: Full=Toll-like receptor 2 {ECO:0000256|ARBA:ARBA00017391, ECO:0000256|PIRNR:PIRNR037595};
GN Name=TLR2 {ECO:0000313|EMBL:ADM52314.1};
OS Micromys minutus (European harvest mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Micromys.
OX NCBI_TaxID=13151 {ECO:0000313|EMBL:ADM52314.1};
RN [1] {ECO:0000313|EMBL:ADM52314.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=21418116; DOI=10.1111/j.1420-9101.2011.02254.x;
RA Tschirren B., Raberg L., Westerdahl H.;
RT "Signatures of selection acting on the innate immunity gene Toll-like
RT receptor 2 (TLR2) during the evolutionary history of rodents.";
RL J. Evol. Biol. 24:1232-1240(2011).
CC -!- FUNCTION: Cooperates with LY96 to mediate the innate immune response to
CC bacterial lipoproteins and other microbial cell wall components.
CC Cooperates with TLR1 or TLR6 to mediate the innate immune response to
CC bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6,
CC leading to NF-kappa-B activation, cytokine secretion and the
CC inflammatory response. {ECO:0000256|PIRNR:PIRNR037595}.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, phagosome membrane
CC {ECO:0000256|ARBA:ARBA00004596}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004596}. Membrane raft
CC {ECO:0000256|ARBA:ARBA00004285}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634, ECO:0000256|PIRNR:PIRNR037595}.
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DR EMBL; HM215603; ADM52314.1; -; Genomic_DNA.
DR GO; GO:0045121; C:membrane raft; IEA:UniProtKB-SubCell.
DR GO; GO:0030670; C:phagocytic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-UniRule.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-UniRule.
DR GO; GO:0001819; P:positive regulation of cytokine production; IEA:UniProt.
DR GO; GO:0032680; P:regulation of tumor necrosis factor production; IEA:UniProt.
DR GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:UniProtKB-UniRule.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR017241; Toll-like_receptor.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR24365; TOLL-LIKE RECEPTOR; 1.
DR PANTHER; PTHR24365:SF17; TOLL-LIKE RECEPTOR 2; 1.
DR Pfam; PF13855; LRR_8; 2.
DR Pfam; PF01582; TIR; 1.
DR PIRSF; PIRSF037595; Toll-like_receptor; 1.
DR PRINTS; PR00019; LEURICHRPT.
DR SMART; SM00364; LRR_BAC; 5.
DR SMART; SM00369; LRR_TYP; 7.
DR SMART; SM00082; LRRCT; 1.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 3.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Immunity {ECO:0000256|ARBA:ARBA00022859, ECO:0000256|PIRNR:PIRNR037595};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198,
KW ECO:0000256|PIRNR:PIRNR037595};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588,
KW ECO:0000256|PIRNR:PIRNR037595};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|PIRNR:PIRNR037595};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..784
FT /note="Toll-like receptor 2"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003143406"
FT DOMAIN 639..782
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT UNSURE 733
FT /note="I or L"
FT /evidence="ECO:0000313|EMBL:ADM52314.1"
SQ SEQUENCE 784 AA; 89443 MW; E44755F03161F37D CRC64;
MPGALWICWI LVAMTGLSRE GCSAQASLSC DAAGVCDGRS QSFTSIPSGL TAAMKTLDLS
FNKISHIGHS DLRACVTLQV LKLQSNRIKT IDGDAFESLG SLERLDLSDN ELSSLSSSWF
RPLSSLNCLN LMGNSYRTLG ETSLFSNLTN LQTLRVGNVH TFSEMRRRDF ARLTSLNELE
IKALNLHNYE SGSLKSIRDL YHLTLHLRES TFLLRIFABX LXSVRYFELK DTNLARFPVS
YLSVDEINSP MKMLTFRHAY LTDESFNELL KLLQYILELS EVEFDDCTLN GVGDFNPLEA
GVVKELGNVE TVTIRRLYIP QFYLFYDLST VYSLLEKVKR ITVENSKVFL VPCFFSQHLK
SLEFLDLSEN LMVEEYLKNS ACEGGWPSLQ TLVLSQNHLR SIQKTGEILL TLKNLTALDI
SRNSFQPMPD RCQWPGKLRF LNLSSTGIQA VKTCIPQTLE VLDVSNNNLD SFSLFLPRLQ
XLYISRNKLK TLPDASLLPA LVVMKIRQNA VSTFSKDQLG SFPKLETLEA GDNHFICSCE
LLSFTLETPA LAHVLVDWPD SYRCDSPQRL HGQKIQDARP SVLEXXQAAL VAGVCCAFLL
LXLLIGALCH HFHGLWXLRM MWAWLRAKRK PKKAPCRDIL YDAFVSYSEQ DSYWVENXMV
QQLENSDPPF KLCLHKRDFV PGKWIIDNVI DSIEKSHKTV FVLXENXVRS EWXKYELDFS
HFRLFDENND SAXLVLLEPI EKKAIPQRFC KLRKIMNKKT YLEWPLDDSQ QEVFWGNLRT
AIKS
//
