ID E1AA77_NEIME Unreviewed; 365 AA.
AC E1AA77;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=Cytochrome c oxidase subunit III {ECO:0000256|ARBA:ARBA00029635};
GN Name=ccoP {ECO:0000313|EMBL:ADM88992.1};
OS Neisseria meningitidis.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC Neisseria.
OX NCBI_TaxID=487 {ECO:0000313|EMBL:ADM88992.1};
RN [1] {ECO:0000313|EMBL:ADM88992.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=OX9930134 {ECO:0000313|EMBL:ADM88992.1}, OX9930254
RC {ECO:0000313|EMBL:ADM88993.1}, and OX9930310
RC {ECO:0000313|EMBL:ADM88994.1};
RX PubMed=20808844; DOI=10.1371/journal.ppat.1001055;
RA Aspholm M., Aas F.E., Harrison O.B., Quinn D., Vik A., Viburiene R.,
RA Tonjum T., Moir J., Maiden M.C., Koomey M.;
RT "Structural alterations in a component of cytochrome c oxidase and
RT molecular evolution of pathogenic Neisseria in humans.";
RL PLoS Pathog. 6:e1001055-e1001055(2010).
CC -!- COFACTOR:
CC Name=heme c; Xref=ChEBI:CHEBI:61717;
CC Evidence={ECO:0000256|ARBA:ARBA00001926};
CC -!- PATHWAY: Energy metabolism; oxidative phosphorylation.
CC {ECO:0000256|ARBA:ARBA00004673}.
CC -!- SIMILARITY: Belongs to the CcoP / FixP family.
CC {ECO:0000256|ARBA:ARBA00006113}.
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DR EMBL; HM543252; ADM88992.1; -; Genomic_DNA.
DR EMBL; HM543253; ADM88993.1; -; Genomic_DNA.
DR EMBL; HM543254; ADM88994.1; -; Genomic_DNA.
DR AlphaFoldDB; E1AA77; -.
DR UniPathway; UPA00705; -.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0009055; F:electron transfer activity; IEA:InterPro.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0006119; P:oxidative phosphorylation; IEA:UniProtKB-UniPathway.
DR GO; GO:1902600; P:proton transmembrane transport; IEA:UniProtKB-KW.
DR Gene3D; 6.10.280.130; -; 1.
DR Gene3D; 1.10.760.10; Cytochrome c-like domain; 2.
DR InterPro; IPR032858; CcoP_N.
DR InterPro; IPR038414; CcoP_N_sf.
DR InterPro; IPR009056; Cyt_c-like_dom.
DR InterPro; IPR036909; Cyt_c-like_dom_sf.
DR InterPro; IPR008168; Cyt_C_IC.
DR InterPro; IPR004678; Cyt_c_oxidase_cbb3_su3.
DR NCBIfam; TIGR00782; ccoP; 1.
DR PANTHER; PTHR33751; CBB3-TYPE CYTOCHROME C OXIDASE SUBUNIT FIXP; 1.
DR PANTHER; PTHR33751:SF1; CBB3-TYPE CYTOCHROME C OXIDASE SUBUNIT FIXP; 1.
DR Pfam; PF13442; Cytochrome_CBB3; 2.
DR Pfam; PF14715; FixP_N; 1.
DR PRINTS; PR00605; CYTCHROMECIC.
DR SUPFAM; SSF46626; Cytochrome c; 2.
DR PROSITE; PS51007; CYTC; 2.
PE 3: Inferred from homology;
KW Cell inner membrane {ECO:0000256|ARBA:ARBA00022519};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Electron transport {ECO:0000256|ARBA:ARBA00022982};
KW Heme {ECO:0000256|ARBA:ARBA00022617, ECO:0000256|PROSITE-ProRule:PRU00433};
KW Hydrogen ion transport {ECO:0000256|ARBA:ARBA00022781};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|PROSITE-ProRule:PRU00433};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW ProRule:PRU00433}; Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Respiratory chain {ECO:0000256|ARBA:ARBA00022660};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 66..88
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 134..213
FT /note="Cytochrome c"
FT /evidence="ECO:0000259|PROSITE:PS51007"
FT DOMAIN 222..305
FT /note="Cytochrome c"
FT /evidence="ECO:0000259|PROSITE:PS51007"
FT REGION 308..365
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 347..365
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 365 AA; 40039 MW; EFCC2552A51EB4B4 CRC64;
MNTTSQFTSN FWNIYIAVIV LLSFIALAWL LLSQNVVKRP KKGEEVQTTG HEWDGIAEYD
NPLPRWWFWL CVLTWLFGIG YLVMYPGVGD YKGLLKWTSH NQYEKEVKKA DEQYGKLYAK
FADMPIEKVA KDPQAKQIAQ NLFNTYCIQC HGSDAKGSKG FPNLTDSDWL WGGDPDKIHE
TIEKGRVATM PAWGPALGEE GVKDVAHYVM SLSKPEGQYD EERAARGQAL FSGPPANCFT
CHGDKGQGIQ GLGPNLTDDV WLWGGTQKSI IETITNGRSS QMPAWGHFLD KDKLHIMTAY
VWGLSDKDGK APVKKAEPAP TPAPAAEPAA SAPVEAAQAA SEAKPAAAEP KAEEKAAPAA
KADGK
//
