GenomeNet

Database: UniProt
Entry: E1ACK1_9SAUR
LinkDB: E1ACK1_9SAUR
Original site: E1ACK1_9SAUR 
ID   E1ACK1_9SAUR            Unreviewed;       346 AA.
AC   E1ACK1;
DT   02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2010, sequence version 1.
DT   24-JAN-2024, entry version 53.
DE   RecName: Full=V(D)J recombination-activating protein 1 {ECO:0000256|ARBA:ARBA00021277};
DE            EC=2.3.2.27 {ECO:0000256|ARBA:ARBA00012483};
DE   Flags: Fragment;
GN   Name=RAG-1 {ECO:0000313|EMBL:ADK73540.1};
OS   Hemidactylus platyurus (flat-tailed house gecko).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Gekkota; Gekkonidae; Gekkoninae;
OC   Hemidactylus.
OX   NCBI_TaxID=498596 {ECO:0000313|EMBL:ADK73540.1};
RN   [1] {ECO:0000313|EMBL:ADK73540.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=20601015; DOI=10.1016/j.ympev.2010.06.008;
RA   Bansal R., Karanth K.P.;
RT   "Molecular phylogeny of Hemidactylus geckos (Squamata: Gekkonidae) of the
RT   Indian subcontinent reveals a unique Indian radiation and an Indian origin
RT   of Asian house geckos.";
RL   Mol. Phylogenet. Evol. 57:459-465(2010).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC         [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC         cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC         EC=2.3.2.27; Evidence={ECO:0000256|ARBA:ARBA00000900};
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|ARBA:ARBA00001946};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|ARBA:ARBA00001936};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; HM622363; ADK73540.1; -; Genomic_DNA.
DR   AlphaFoldDB; E1ACK1; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR   GO; GO:0004519; F:endonuclease activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0042803; F:protein homodimerization activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:InterPro.
DR   GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR   GO; GO:0033151; P:V(D)J recombination; IEA:InterPro.
DR   CDD; cd16530; RING-HC_RAG1; 1.
DR   Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR   Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR   InterPro; IPR024627; RAG1.
DR   InterPro; IPR035714; RAG1_imp-bd.
DR   InterPro; IPR019485; RAG1_Znf.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR018957; Znf_C3HC4_RING-type.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   InterPro; IPR017907; Znf_RING_CS.
DR   PANTHER; PTHR11539:SF0; V(D)J RECOMBINATION-ACTIVATING PROTEIN 1; 1.
DR   PANTHER; PTHR11539; VDJ RECOMBINATION ACTIVATING PROTEIN 1 RAG1; 1.
DR   Pfam; PF12560; RAG1_imp_bd; 1.
DR   Pfam; PF00097; zf-C3HC4; 1.
DR   Pfam; PF10426; zf-RAG1; 1.
DR   SMART; SM00184; RING; 1.
DR   SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 1.
DR   SUPFAM; SSF57850; RING/U-box; 1.
DR   PROSITE; PS51765; ZF_RAG1; 1.
DR   PROSITE; PS00518; ZF_RING_1; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   4: Predicted;
KW   DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU01101}.
FT   DOMAIN          252..291
FT                   /note="RING-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50089"
FT   DOMAIN          313..342
FT                   /note="RAG1-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51765"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:ADK73540.1"
FT   NON_TER         346
FT                   /evidence="ECO:0000313|EMBL:ADK73540.1"
SQ   SEQUENCE   346 AA;  39534 MW;  8FDF9C9227D20102 CRC64;
     KPLPEESHLA KSDNREMAAS LDKVNDAMTI MLQEPFHRGQ NLNNSMQSID KDAFSVNQRE
     IEAHQVNLQH LCRICGGSFK NDLYKRSHPV HGPVDDEMQA LLRKKERKAT SWPDLLNKVF
     KVDVRGDMDT IHPTNFCHNC WSVVQRKFSN VPCEVYFPRK GTMEWHPHST SCDVCGSSSH
     GIKRKTQDPS PQGGKKLRII AERARKIMYA RSQKQANNKS IMKKITNCKK IHLSTKMLTV
     DYPVDFVKSI SCQICEHILA DPVETTCKHL FCRLCILKCL KVIGSYCPSC RYPCFPTDLV
     NPVRSFLSIL NILAVRCPVK DCHEEVTLGK YSRHLSSHKE KKEKGT
//
DBGET integrated database retrieval system