ID E1B6Y9_BOVIN Unreviewed; 731 AA.
AC E1B6Y9;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 2.
DT 27-MAR-2024, entry version 91.
DE SubName: Full=Transient receptor potential cation channel subfamily V member 5 {ECO:0000313|Ensembl:ENSBTAP00000002485.4};
GN Name=TRPV5 {ECO:0000313|Ensembl:ENSBTAP00000002485.4,
GN ECO:0000313|VGNC:VGNC:36401};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000002485.4, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000002485.4, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000002485.4,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000002485.4}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000002485.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; XP_010802928.1; XM_010804626.2.
DR RefSeq; XP_010802929.1; XM_010804627.2.
DR RefSeq; XP_010825727.1; XM_010827425.2.
DR RefSeq; XP_010825729.1; XM_010827427.2.
DR AlphaFoldDB; E1B6Y9; -.
DR SMR; E1B6Y9; -.
DR STRING; 9913.ENSBTAP00000002485; -.
DR PaxDb; 9913-ENSBTAP00000002485; -.
DR Ensembl; ENSBTAT00000002485.4; ENSBTAP00000002485.4; ENSBTAG00000001912.4.
DR GeneID; 524365; -.
DR KEGG; bta:524365; -.
DR CTD; 56302; -.
DR VEuPathDB; HostDB:ENSBTAG00000001912; -.
DR VGNC; VGNC:36401; TRPV5.
DR eggNOG; KOG3676; Eukaryota.
DR GeneTree; ENSGT00940000161809; -.
DR HOGENOM; CLU_012795_2_0_1; -.
DR InParanoid; E1B6Y9; -.
DR OMA; AYETHED; -.
DR OrthoDB; 1003028at2759; -.
DR TreeFam; TF314711; -.
DR Reactome; R-BTA-3295583; TRP channels.
DR Proteomes; UP000009136; Chromosome 4.
DR Bgee; ENSBTAG00000001912; Expressed in conceptus and 7 other cell types or tissues.
DR GO; GO:0016324; C:apical plasma membrane; IEA:Ensembl.
DR GO; GO:0034704; C:calcium channel complex; IEA:Ensembl.
DR GO; GO:0005262; F:calcium channel activity; IEA:Ensembl.
DR GO; GO:0055074; P:calcium ion homeostasis; IEA:Ensembl.
DR GO; GO:0035809; P:regulation of urine volume; IEA:Ensembl.
DR CDD; cd22296; CBD_TRPV5_C; 1.
DR CDD; cd22192; TRPV5-6; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 2.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR024862; TRPV.
DR InterPro; IPR008346; TRPV5.
DR InterPro; IPR008344; TRPV5/TRPV6.
DR NCBIfam; TIGR00870; trp; 1.
DR PANTHER; PTHR10582:SF11; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY V MEMBER 5; 1.
DR PANTHER; PTHR10582; TRANSIENT RECEPTOR POTENTIAL ION CHANNEL PROTEIN; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF13637; Ank_4; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR PRINTS; PR01415; ANKYRIN.
DR PRINTS; PR01765; ECACCHANNEL.
DR PRINTS; PR01767; ECACCHANNEL2.
DR SMART; SM00248; ANK; 4.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 2.
DR PROSITE; PS50088; ANK_REPEAT; 2.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 328..352
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 425..445
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 451..469
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 490..512
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 553..575
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 116..148
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 162..194
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 353..588
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 653..672
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 731 AA; 82871 MW; 444231E447B31DCB CRC64;
MGAPPSKARG LWIQLQKLLT SWLVGQQDWD QRLDEMYMLQ QQKIRESPLL RAAKDNDLCV
LKKLLLDRNC DFRQRGAVGE TALHVAALYD NLEAAMVLME AAPELVKEPA ICEPFVGQTA
LHIAVMNRNV NLVKALLAQG ASVSARAIGS AFRLTPHNLI YFGEHPLSFA ACMGSEEIVR
LLIEHGADIR AQDSLGNTVL HILVLQPNKT FACQMYNLLL SYDRRGDHLQ SLDLMLNHQG
LTPFKLAGVE GNTVMFQHLM QKRKYIQWTC GPLTSTLYDL TEIDSWGEDV SFLELVVSSK
KREARQILEQ TPVKQLVNFK WRKYGRPYFC ILGALYVLYM ICFTMCCIHR PLKARSGNRT
DSRDITVFQQ KLLQEAYVTQ QDKIRLVGEL MTVIGSAIIL FLEIPDIFRV GFSRYFGQTV
LGGPFHVITI TYSFLVLVTM VMRLTNTSGE VVPMSFALVL GWCSVMYFAR GFQMLGPFTI
MIQKMIFGDL LRFCWLMAVV IVGFASAFYI IFQTEDPSAL GEFYDYPMAL FSTFELFLTI
IDGPANYDVD LPFMYSIVYF AFAIIATLLM INLLVAMMGD THWRVAHEQD ELWRAQVVAT
TVMLERKMPR TLWPRSGICG YKYGLGDRWF LRVETNQDQN TLRARRYVEA FKGSDKEEGQ
GHPPEKRPSV TESGLLARAS LALPTPSLSR TTSRSSGSHR GWEIIRRNTL GHVNLGLDLG
EGDGDDRVYQ L
//
