UniProt: E1B8N5

Database: UniProt
Entry: E1B8N5_BOVIN

LinkDB:  E1B8N5_BOVIN 
Original site:  E1B8N5_BOVIN

All links

Ontology (17)   
   GO (17)   
Gene (5)   
   KEGG GENES (1)   
   NCBI-Gene (1)   
   ENSEMBL-UP (3)   
Protein sequence (2)   
   RefSeq(pep) (2)   
Protein domain (18)   
   InterPro (11)   
   Pfam (5)   
   PROSITE (1)   
   SMART (1)   
All databases (42)   

Download RDF

ID   E1B8N5_BOVIN            Unreviewed;      1030 AA.
AC   E1B8N5;
DT   02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 2.
DT   27-MAR-2024, entry version 97.
DE   RecName: Full=Sodium/potassium-transporting ATPase subunit alpha {ECO:0000256|RuleBase:RU362084};
GN   Name=ATP1A4 {ECO:0000313|Ensembl:ENSBTAP00000013951.5,
GN   ECO:0000313|VGNC:VGNC:26284};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000013951.5, ECO:0000313|Proteomes:UP000009136};
RN   [1] {ECO:0000313|Ensembl:ENSBTAP00000013951.5, ECO:0000313|Proteomes:UP000009136}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000013951.5,
RC   ECO:0000313|Proteomes:UP000009136};
RA   Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA   Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA   Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT   "ARS-UCD1.2.";
RL   Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSBTAP00000013951.5}
RP   IDENTIFICATION.
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000013951.5};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU362084};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU362084}.
CC   -!- SIMILARITY: Belongs to the cation transport ATPase (P-type) (TC 3.A.3)
CC       family. Type IIC subfamily. {ECO:0000256|ARBA:ARBA00006934,
CC       ECO:0000256|RuleBase:RU362084}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   RefSeq; NP_001137575.2; NM_001144103.2.
DR   RefSeq; XP_005203590.1; XM_005203533.3.
DR   AlphaFoldDB; E1B8N5; -.
DR   SMR; E1B8N5; -.
DR   STRING; 9913.ENSBTAP00000013951; -.
DR   PaxDb; 9913-ENSBTAP00000013951; -.
DR   Ensembl; ENSBTAT00000013951.6; ENSBTAP00000013951.5; ENSBTAG00000038523.3.
DR   GeneID; 537960; -.
DR   KEGG; bta:537960; -.
DR   CTD; 480; -.
DR   VEuPathDB; HostDB:ENSBTAG00000038523; -.
DR   VGNC; VGNC:26284; ATP1A4.
DR   eggNOG; KOG0203; Eukaryota.
DR   GeneTree; ENSGT00940000162378; -.
DR   HOGENOM; CLU_002360_4_1_1; -.
DR   InParanoid; E1B8N5; -.
DR   OMA; NGQEYSM; -.
DR   OrthoDB; 203629at2759; -.
DR   TreeFam; TF312838; -.
DR   Reactome; R-BTA-5578775; Ion homeostasis.
DR   Reactome; R-BTA-936837; Ion transport by P-type ATPases.
DR   Proteomes; UP000009136; Chromosome 3.
DR   Bgee; ENSBTAG00000038523; Expressed in spermatid and 37 other cell types or tissues.
DR   GO; GO:0042995; C:cell projection; IBA:GO_Central.
DR   GO; GO:0045121; C:membrane raft; IDA:ARUK-UCL.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005890; C:sodium:potassium-exchanging ATPase complex; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0019900; F:kinase binding; IPI:ARUK-UCL.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0005391; F:P-type sodium:potassium-exchanging transporter activity; IMP:ARUK-UCL.
DR   GO; GO:0007166; P:cell surface receptor signaling pathway; IDA:ARUK-UCL.
DR   GO; GO:0030007; P:intracellular potassium ion homeostasis; IBA:GO_Central.
DR   GO; GO:0006883; P:intracellular sodium ion homeostasis; IBA:GO_Central.
DR   GO; GO:1990573; P:potassium ion import across plasma membrane; IBA:GO_Central.
DR   GO; GO:0071805; P:potassium ion transmembrane transport; IMP:ARUK-UCL.
DR   GO; GO:1902600; P:proton transmembrane transport; IBA:GO_Central.
DR   GO; GO:0036376; P:sodium ion export across plasma membrane; IBA:GO_Central.
DR   GO; GO:0035725; P:sodium ion transmembrane transport; IMP:ARUK-UCL.
DR   CDD; cd02608; P-type_ATPase_Na-K_like; 1.
DR   Gene3D; 3.40.1110.10; Calcium-transporting ATPase, cytoplasmic domain N; 1.
DR   Gene3D; 2.70.150.10; Calcium-transporting ATPase, cytoplasmic transduction domain A; 1.
DR   Gene3D; 1.20.1110.10; Calcium-transporting ATPase, transmembrane domain; 1.
DR   Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR   InterPro; IPR006068; ATPase_P-typ_cation-transptr_C.
DR   InterPro; IPR004014; ATPase_P-typ_cation-transptr_N.
DR   InterPro; IPR023299; ATPase_P-typ_cyto_dom_N.
DR   InterPro; IPR018303; ATPase_P-typ_P_site.
DR   InterPro; IPR023298; ATPase_P-typ_TM_dom_sf.
DR   InterPro; IPR008250; ATPase_P-typ_transduc_dom_A_sf.
DR   InterPro; IPR036412; HAD-like_sf.
DR   InterPro; IPR023214; HAD_sf.
DR   InterPro; IPR005775; P-type_ATPase_IIC.
DR   InterPro; IPR001757; P_typ_ATPase.
DR   InterPro; IPR044492; P_typ_ATPase_HD_dom.
DR   NCBIfam; TIGR01106; ATPase-IIC_X-K; 1.
DR   NCBIfam; TIGR01494; ATPase_P-type; 2.
DR   PANTHER; PTHR43294; SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA; 1.
DR   PANTHER; PTHR43294:SF3; SODIUM_POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA-4; 1.
DR   Pfam; PF13246; Cation_ATPase; 1.
DR   Pfam; PF00689; Cation_ATPase_C; 1.
DR   Pfam; PF00690; Cation_ATPase_N; 1.
DR   Pfam; PF00122; E1-E2_ATPase; 1.
DR   Pfam; PF00702; Hydrolase; 1.
DR   PRINTS; PR00119; CATATPASE.
DR   PRINTS; PR00121; NAKATPASE.
DR   SFLD; SFLDS00003; Haloacid_Dehalogenase; 1.
DR   SFLD; SFLDF00027; p-type_atpase; 1.
DR   SMART; SM00831; Cation_ATPase_N; 1.
DR   SUPFAM; SSF81653; Calcium ATPase, transduction domain A; 1.
DR   SUPFAM; SSF81665; Calcium ATPase, transmembrane domain M; 1.
DR   SUPFAM; SSF56784; HAD-like; 1.
DR   SUPFAM; SSF81660; Metal cation-transporting ATPase, ATP-binding domain N; 1.
DR   PROSITE; PS00154; ATPASE_E1_E2; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU362084};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW   ECO:0000256|RuleBase:RU362084};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362084};
KW   Metal-binding {ECO:0000256|RuleBase:RU362084};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU362084};
KW   Potassium {ECO:0000256|ARBA:ARBA00022958, ECO:0000256|RuleBase:RU362084};
KW   Potassium transport {ECO:0000256|ARBA:ARBA00022538,
KW   ECO:0000256|RuleBase:RU362084};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW   Translocase {ECO:0000256|ARBA:ARBA00022967};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU362084};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU362084}; Transport {ECO:0000256|RuleBase:RU362084}.
FT   TRANSMEM        105..127
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362084"
FT   TRANSMEM        139..158
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362084"
FT   TRANSMEM        300..324
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362084"
FT   TRANSMEM        330..353
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362084"
FT   TRANSMEM        783..805
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362084"
FT   TRANSMEM        811..831
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362084"
FT   TRANSMEM        852..879
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362084"
FT   TRANSMEM        920..939
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362084"
FT   TRANSMEM        960..980
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362084"
FT   TRANSMEM        992..1008
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362084"
FT   DOMAIN          51..125
FT                   /note="Cation-transporting P-type ATPase N-terminal"
FT                   /evidence="ECO:0000259|SMART:SM00831"
FT   REGION          1..44
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1030 AA;  113734 MW;  C49EA31D56826B2A CRC64;
     MGLGGKKGAV TPHERNPNPG PTNSPKMSKK KMKRKKKKKD IEELKKEVVM DDHKLTLDEL
     SAKYSVDLTR GHSPEKAQEI LTRDGPNALT PPSTTPEWVK FCKQLFGGFS LLLWTGAILC
     FVAFGIQLYF NEDTTKDNLY LGIVLTVVVI ITGCFSYYQE AKSSKIMESF KNMVPQQALV
     IRGGEKFQIP VYEVVVGDLV EVKGGDRIPA DIRLISSQGC KVDNSSLTGE SEPQSRSTEF
     TNENPLETQN ICFFSTNCVE GSAQGIVIAT GDSTVMGRIA SLTSGLAVGK TPIAIELEHF
     IHLITGVAVF LGVTFFGLSL ILGYTWLEAV IFLIGIIVAN VPEGLLATVT VCLTLTAKRM
     ARKNCLVKNL EAVETLGSTS TICSDKTGTL TQNRMTVAHL WFDKTIYEAD TTEEQTGNPF
     AKGSDTWFIL ARIAGLCNRA DFKANEESLP IAKRATTGDA SESALLKFIE QSYSSVNEMR
     EKSPKVAEIP FNSTNKYQVS IHLREDSSQA HVLMMKGAPE RILEFCSTYL LKGQEYPIDD
     EMKDAFQNAY LDLGGLGERV LGFCFLNLPN TYPKGFKFNT DEINFPINNL CFVGLISMID
     PPRAAVPDAV GKCRSAGIKV IMVTGDHPIT AKAIAKGVGI ISEGSETAED IAARLKIPVS
     KVNPRDAQAI VVHGSELKNM NSEQLDEILQ NHTEIVFART SPQQKLIIVE GCQRLGAIVA
     VTGDGVNDSP ALKKADIGIA MGIAGSDVSK QAADMILLDD NFASIVTGVE EGRLIFDNLK
     KSIAYTLTSN IPEITPFLMF IILGIPLPLG TITILCIDLG TDMVPAISLA YESAESDIMK
     RAPRNSKTDK LVNHRLIGMA YGQIGMIQAL AGFFTYFVIL AENGFKPPDL LGIRVNWENR
     YINDLEDSYG QQWTYEQRKV LEFTCQTAFF VSIVIVQWAD LIICKTRRNS IFQQGMKNKI
     LIFGILEETI LAAFLSYTPG MDVALRMYPL KITWWFCATP YSLLIFVYDE IRRLIIRRYP
     GGWVEKETYY
//

DBGET integrated database retrieval system