ID E1B918_BOVIN Unreviewed; 333 AA.
AC E1B918;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 80.
DE SubName: Full=Homeobox A1 {ECO:0000313|Ensembl:ENSBTAP00000001367.2};
GN Name=HOXA1 {ECO:0000313|Ensembl:ENSBTAP00000001367.2,
GN ECO:0000313|VGNC:VGNC:29908};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000001367.2, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000001367.2, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000001367.2,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000001367.2}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000001367.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
CC -!- SIMILARITY: Belongs to the Antp homeobox family. Labial subfamily.
CC {ECO:0000256|ARBA:ARBA00029448}.
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DR RefSeq; NP_001193040.1; NM_001206111.1.
DR AlphaFoldDB; E1B918; -.
DR SMR; E1B918; -.
DR STRING; 9913.ENSBTAP00000001367; -.
DR PaxDb; 9913-ENSBTAP00000001367; -.
DR Ensembl; ENSBTAT00000001367.3; ENSBTAP00000001367.2; ENSBTAG00000013263.3.
DR GeneID; 537889; -.
DR KEGG; bta:537889; -.
DR CTD; 3198; -.
DR VEuPathDB; HostDB:ENSBTAG00000013263; -.
DR VGNC; VGNC:29908; HOXA1.
DR eggNOG; KOG0489; Eukaryota.
DR GeneTree; ENSGT00940000157315; -.
DR HOGENOM; CLU_058839_1_1_1; -.
DR InParanoid; E1B918; -.
DR OMA; SAQTFDW; -.
DR OrthoDB; 728401at2759; -.
DR TreeFam; TF317730; -.
DR Proteomes; UP000009136; Chromosome 4.
DR Bgee; ENSBTAG00000013263; Expressed in semen and 53 other cell types or tissues.
DR ExpressionAtlas; E1B918; baseline.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR InterPro; IPR046327; HXA1/B1/D1.
DR PANTHER; PTHR45946:SF3; HOMEOBOX PROTEIN HOX-A1; 1.
DR PANTHER; PTHR45946; HOMEOBOX PROTEIN ROUGH-RELATED; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000009136}.
FT DOMAIN 225..285
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 227..286
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 58..81
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 279..333
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 311..333
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 333 AA; 36255 MW; 833BD6851DCE5EF9 CRC64;
MDNARMSSFL EYPILSGGDS GTCSARAYPS DHGITTFQSC AVSANSCGSD DRFLVGRGVQ
ISPPHHHHHH HHPQPTTYQT SGNLGVSYSH SSCGPSYSAQ NFGAPYSPYA LNQEAEVSGG
YPSCAPAVYS GNLSSPMVQH HHHHQGYAGG AVGSPQYIHH SYGQEHQSLA LATYNNSLSP
LHASHQEACR SPASETSSPA QTFDWMKVKR NPPKTGKIGE YGYVGQPNAV RTNFTTKQLT
ELEKEFHFNK YLTRARRVEI AASLQLNETQ VKIWFQNRRM KQKKREKEGL LPISPATPTG
SEEKAEESSE KSSSSPCVPS PGSSTSDTLP TSH
//
