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Database: UniProt
Entry: E1B9G2_BOVIN
LinkDB: E1B9G2_BOVIN
Original site: E1B9G2_BOVIN 
ID   E1B9G2_BOVIN            Unreviewed;      2007 AA.
AC   E1B9G2;
DT   02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 2.
DT   07-JUN-2017, entry version 54.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=SCN3A {ECO:0000313|Ensembl:ENSBTAP00000025829};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000025829, ECO:0000313|Proteomes:UP000009136};
RN   [1] {ECO:0000313|Ensembl:ENSBTAP00000025829, ECO:0000313|Proteomes:UP000009136}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000025829,
RC   ECO:0000313|Proteomes:UP000009136};
RX   PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42;
RA   Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C.,
RA   Puiu D., Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S.,
RA   Marcais G., Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.;
RT   "A whole-genome assembly of the domestic cow, Bos taurus.";
RL   Genome Biol. 10:R42.01-R42.10(2009).
RN   [2] {ECO:0000313|Ensembl:ENSBTAP00000025829}
RP   IDENTIFICATION.
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000025829};
RG   Ensembl;
RL   Submitted (MAR-2016) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSBTAP00000025829}.
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DR   EMBL; DAAA02004364; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9913.ENSBTAP00000025829; -.
DR   PaxDb; E1B9G2; -.
DR   Ensembl; ENSBTAT00000025829; ENSBTAP00000025829; ENSBTAG00000019385.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   InParanoid; E1B9G2; -.
DR   OMA; EGCIKKF; -.
DR   TreeFam; TF323985; -.
DR   Proteomes; UP000009136; Chromosome 2.
DR   Bgee; ENSBTAG00000019385; -.
DR   ExpressionAtlas; E1B9G2; baseline.
DR   GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IBA:GO_Central.
DR   GO; GO:0086010; P:membrane depolarization during action potential; IBA:GO_Central.
DR   GO; GO:0019228; P:neuronal action potential; IBA:GO_Central.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   PROSITE; PS50096; IQ; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000009136};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    129    153       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    198    217       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    229    250       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    256    276       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    406    433       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    768    786       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    798    821       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    878    906       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    968    991       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1214   1232       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1253   1275       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1281   1301       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1330   1356       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1451   1475       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1534   1552       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1564   1582       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1589   1614       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1651   1679       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1755   1778       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      134    440       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      515    717       Na_trans_cytopl. {ECO:0000259|Pfam:
FT                                PF11933}.
FT   DOMAIN      768    996       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1005   1207       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1212   1483       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1533   1788       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      430    475       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2007 AA;  227200 MW;  92740860C4A21595 CRC64;
     MAQALLVPPG PESFRLFTRE SLAAIEKRAA EEKAKKPKKE QDNDEENEPK PNSDLEAGKN
     LPFIYGDIPP GMVSEPLEDL DPYYINKKTF IVLNKGKAIF RFSATSALYI LTPLNPIRKI
     AIKILVHSYP FYSTLFSMLI MCTILTNCVF MTLSNPPDWT KNVEYTFTGI YTFESLIKIL
     ARGFCLEDFT FLRDPWNWLD FSVIVMAYVT EFVNLGNVSA LRTFRVLRAL KTISVIPGLK
     TIVGALIQSV KKLSDVMILT VFCLSVFALI GLQLFMGNLR NKCLQWPPSD SAFETNTTSL
     FNGTMNSNGT FVNVTMSTFN WKDYIEDDSH FYVLDGQNDP LLCGNGSDAG QCPEGYICVK
     AGRNPNYGYT SFDTFSWAFL SLFRLMTQDY WENLYQLTLR AAGKTYMIFF VLVIFLGSFY
     LVNLILAVVA MAYEEQNQAT LEEAEQKEAE FQQMLEQIKK QQEEAQEAAV AAASAASRDF
     SGIGGLGELL ESSSEASKLS SKSAKEWRNR RKKRRQRENL EGNNKGEGNR FPKSESEDSV
     KRRSFLFSMD GNRLTSDKKF YSPHQSLLSI RGSLFSPRRN SKTSIFSFRG RAKDIGSEND
     FADDEHSTFE DSESRRDSLF VPHRHGERRN SNVSQASMSS RMVPGLPANG KMHSTVDCNG
     VVSLVGGPSA LTSPTGHRPE GTTTETEVRK RRLSSYQISM EMLEDSSGRQ RAMSIASILT
     NTMEELEESR QKCPPCWYRF ANMFLIWDCC DAWLKVKHLV NLIVMDPFVD LAITICIVLN
     TLFMAMEHYP MTGQFSSVLT VGNLVFTGIF TAEMVLKIIA MDPYYYFQEG WNIFDGIIVS
     LSLMELGLAN VEGLSVLRSF RLLRVFKLAK SWPTLNMLIK IIGNSVGALG NLTLVLAIIV
     FIFAVVGMQL FGKSYKECVC KISSDCELPR WHMNDFFHSF LIVFRVLCGE WIETMWDCME
     VAGQTMCLIV FMLVMVIGNL VVLNLFLALL LSSFSSDNLA ATDDDNEMNN LQIAVGRMQK
     GIDYVKNKIR ECFQKTFFRK PKVIEIHEGN KIDSCVSNNT GIEISKELNY LKDGNGTTSG
     VGTGSSAEKY VIDENDYMSF INNPSLTVTV PIAVGESDFE NLNTEEFSSE SELEESKEKL
     NATSSSEGST VDVAPPREGE QAEIEPEEDL KPEACFTEGC IKKFPFCQVS IEEGKGKIWW
     NLRKTCYSIV EHNWFETFIV FMILLSSGAL AFEDIYIEQR KTIKTMLEYA DKVFTYIFIL
     EMLLKWVAYG FQTYFTNAWC WLDFLIVDVS LVSLVANALG YSELGAIKSL RTLRALRPLR
     ALSRFEGMRV VVNALVGAIP SIMNVLLVCL IFWLIFSIMG VNLFAGKFYH CVNTTTGNMF
     DVSEVNNLSD CQALGKKARW KNVKVNFDNV GAGYLALLQV ATFKGWMDIM YAAVDSRDVK
     LQPVYEENLY MYLYFVIFII FGSFFTLNLF IGVIIDNFNQ QKKKFGGQDI FMTEEQKKYY
     NAMKKLGSKK PQKPIPRPAN KFQGMVFDFV TRQVFDISIM ILICLNMVTM MVETDDQSKY
     MTLVLSRINL VFIILFTGEF VLKLISLRYY YFTIGWNIFD FVVVILSIVG MFLAELIEKY
     FVSPTLFRVI RLARIGRILR LIKGAKGIRT LLFALMMSLP ALFNIGLLLF LVMFIYAIFG
     MSNFAYVKKE AGIDDMFNFE TFGNSMICLF QITTSAGWDG LLAPILNSAP PDCDPDTIHP
     GSSVKGDCGN PSVGIFFFVS YIIISFLVVV NMYIAVILEN FSVATEESAE PLSEDDFEMF
     YEVWEKFDPD ATQFIEFSKL SDFAAALDPP LLIAKPNKVQ LIAMDLPMVS GDRIHCLDIL
     FAFTKRVLGE SGEMDALRIQ MEDRFMASNP SKVSYEPITT TLKRKQEEVS AAIIQRNFRC
     YLLKQRLKKV VNEYNKEAIK GRIDLPIKDD MIIDKLNGNS TPEKTDGSSS TTSPPSYDSV
     TKPDKEKFEK DKPEKESKGK EVRENQK
//
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