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Database: UniProt
Entry: E1BCP0_BOVIN
LinkDB: E1BCP0_BOVIN
Original site: E1BCP0_BOVIN 
ID   E1BCP0_BOVIN            Unreviewed;       871 AA.
AC   E1BCP0;
DT   02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2010, sequence version 1.
DT   22-NOV-2017, entry version 59.
DE   SubName: Full=Transient receptor potential cation channel subfamily V member 4 {ECO:0000313|Ensembl:ENSBTAP00000000034};
GN   Name=TRPV4 {ECO:0000313|Ensembl:ENSBTAP00000000034};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000000034, ECO:0000313|Proteomes:UP000009136};
RN   [1] {ECO:0000313|Ensembl:ENSBTAP00000000034, ECO:0000313|Proteomes:UP000009136}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000000034,
RC   ECO:0000313|Proteomes:UP000009136};
RX   PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42;
RA   Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C.,
RA   Puiu D., Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S.,
RA   Marcais G., Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.;
RT   "A whole-genome assembly of the domestic cow, Bos taurus.";
RL   Genome Biol. 10:R42.01-R42.10(2009).
RN   [2] {ECO:0000313|Ensembl:ENSBTAP00000000034}
RP   IDENTIFICATION.
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000000034};
RG   Ensembl;
RL   Submitted (MAR-2016) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the transient receptor (TC 1.A.4) family.
CC       {ECO:0000256|SAAS:SAAS00933551}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSBTAP00000000034}.
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DR   EMBL; DAAA02045464; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; DAAA02045465; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001179314.1; NM_001192385.1.
DR   RefSeq; XP_005217959.1; XM_005217902.2.
DR   RefSeq; XP_005217960.1; XM_005217903.3.
DR   STRING; 9913.ENSBTAP00000000034; -.
DR   PaxDb; E1BCP0; -.
DR   Ensembl; ENSBTAT00000000034; ENSBTAP00000000034; ENSBTAG00000000031.
DR   GeneID; 540259; -.
DR   KEGG; bta:540259; -.
DR   CTD; 59341; -.
DR   eggNOG; KOG3676; Eukaryota.
DR   eggNOG; ENOG4110DG4; LUCA.
DR   GeneTree; ENSGT00550000074425; -.
DR   InParanoid; E1BCP0; -.
DR   KO; K04973; -.
DR   OMA; KVCNEDQ; -.
DR   OrthoDB; EOG091G016O; -.
DR   TreeFam; TF314711; -.
DR   Reactome; R-BTA-3295583; TRP channels.
DR   Proteomes; UP000009136; Chromosome 17.
DR   Bgee; ENSBTAG00000000031; -.
DR   GO; GO:0005912; C:adherens junction; IEA:Ensembl.
DR   GO; GO:0005929; C:cilium; IBA:GO_Central.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0005262; F:calcium channel activity; IBA:GO_Central.
DR   GO; GO:0005516; F:calmodulin binding; IEA:Ensembl.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0005034; F:osmosensor activity; IEA:Ensembl.
DR   GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
DR   GO; GO:0042169; F:SH2 domain binding; IEA:Ensembl.
DR   GO; GO:0015275; F:stretch-activated, cation-selective, calcium channel activity; IEA:Ensembl.
DR   GO; GO:0007015; P:actin filament organization; IBA:GO_Central.
DR   GO; GO:0097497; P:blood vessel endothelial cell delamination; IEA:Ensembl.
DR   GO; GO:0070509; P:calcium ion import; IEA:Ensembl.
DR   GO; GO:0060351; P:cartilage development involved in endochondral bone morphogenesis; IEA:Ensembl.
DR   GO; GO:0007043; P:cell-cell junction assembly; IEA:Ensembl.
DR   GO; GO:0006874; P:cellular calcium ion homeostasis; IBA:GO_Central.
DR   GO; GO:0071476; P:cellular hypotonic response; IBA:GO_Central.
DR   GO; GO:0071477; P:cellular hypotonic salinity response; IEA:Ensembl.
DR   GO; GO:0034605; P:cellular response to heat; IEA:Ensembl.
DR   GO; GO:0002024; P:diet induced thermogenesis; IEA:Ensembl.
DR   GO; GO:0042593; P:glucose homeostasis; IEA:Ensembl.
DR   GO; GO:0042538; P:hyperosmotic salinity response; IEA:Ensembl.
DR   GO; GO:0050891; P:multicellular organismal water homeostasis; IEA:Ensembl.
DR   GO; GO:1903444; P:negative regulation of brown fat cell differentiation; IEA:Ensembl.
DR   GO; GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
DR   GO; GO:0007231; P:osmosensory signaling pathway; IBA:GO_Central.
DR   GO; GO:0071651; P:positive regulation of chemokine (C-C motif) ligand 5 production; IEA:Ensembl.
DR   GO; GO:2000340; P:positive regulation of chemokine (C-X-C motif) ligand 1 production; IEA:Ensembl.
DR   GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IEA:Ensembl.
DR   GO; GO:2000507; P:positive regulation of energy homeostasis; IEA:Ensembl.
DR   GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IEA:Ensembl.
DR   GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR   GO; GO:0050729; P:positive regulation of inflammatory response; IEA:Ensembl.
DR   GO; GO:2000778; P:positive regulation of interleukin-6 secretion; IEA:Ensembl.
DR   GO; GO:0046330; P:positive regulation of JNK cascade; IEA:Ensembl.
DR   GO; GO:0010759; P:positive regulation of macrophage chemotaxis; IEA:Ensembl.
DR   GO; GO:0071642; P:positive regulation of macrophage inflammatory protein 1 alpha production; IEA:Ensembl.
DR   GO; GO:0071639; P:positive regulation of monocyte chemotactic protein-1 production; IEA:Ensembl.
DR   GO; GO:0043117; P:positive regulation of vascular permeability; IEA:Ensembl.
DR   GO; GO:0047484; P:regulation of response to osmotic stress; IEA:Ensembl.
DR   GO; GO:0032868; P:response to insulin; IEA:Ensembl.
DR   GO; GO:1903759; P:signal transduction involved in regulation of aerobic respiration; IEA:Ensembl.
DR   GO; GO:0030103; P:vasopressin secretion; IEA:Ensembl.
DR   CDD; cd00204; ANK; 1.
DR   Gene3D; 1.25.40.20; -; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR020683; Ankyrin_rpt-contain_dom.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR004729; TRP_channel.
DR   InterPro; IPR024862; TRPV.
DR   InterPro; IPR008347; TRPV1-4_channel.
DR   InterPro; IPR008348; TRPV4_channel.
DR   PANTHER; PTHR10582; PTHR10582; 1.
DR   PANTHER; PTHR10582:SF4; PTHR10582:SF4; 1.
DR   Pfam; PF00023; Ank; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   PRINTS; PR01768; TRPVRECEPTOR.
DR   PRINTS; PR01769; VRL2RECEPTOR.
DR   SMART; SM00248; ANK; 3.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   TIGRFAMs; TIGR00870; trp; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 1.
PE   3: Inferred from homology;
KW   ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023,
KW   ECO:0000256|SAAS:SAAS00933366};
KW   Complete proteome {ECO:0000313|Proteomes:UP000009136};
KW   Ion channel {ECO:0000256|SAAS:SAAS00931870};
KW   Ion transport {ECO:0000256|SAAS:SAAS00929079};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW   Repeat {ECO:0000256|SAAS:SAAS00931009};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|SAAS:SAAS00927442}.
FT   TRANSMEM    469    491       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    511    529       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    550    568       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    574    593       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    614    636       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    693    717       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      237    392       ANK_REP_REGION. {ECO:0000259|PROSITE:
FT                                PS50297}.
FT   REPEAT      237    269       ANK. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00023}.
SQ   SEQUENCE   871 AA;  98237 MW;  6EBA89A4B473D848 CRC64;
     MADPGEGPRV GPGEMAESPG DESGPPGGEA FPLSSLANLF EGEDGSPSPS PADGGRSTGP
     GDGRPNLRMK FQGAFRKGVP NPIDLLESTL YESSVVPGPK KAPMDSLFDY GTYRHHPSDN
     KRWRRKVIEK QPQSPKAPAP QPPPILKVFN RPILFDIVSR GSTADLDGLL PFLLTHKKRL
     TDEEFREPST GKTCLPKALL NLSNGRNDTI PVLLDIAERT GNMREFINSP FRDIYYRGQT
     ALHIAIERRC KHYVELLVAQ GADVHAQARG RFFQPKDEGG YFYFGELPLS LAACTNQPHI
     VNYLTENPHK KADMRRQDSR GNTVLHALVA IADNTRENTK FVTKMYDLLL LKCARLFPDS
     NLEAVLNNDG LSPLMMAAKT GKIGIFQHII RREVTDEDTR HLSRKFKDWA YGPVYSSLYD
     LSSLDTCGEE TSVLEILVYN SKIENRHEML AVEPINELLR DKWRKFGAVS FYINVVSYLC
     AMVIFTLTAY YQPLEGTPPY PYRTTMDYLR LAGEIITLFT GILFFFTNIK DLFMKKCPGV
     NSLFIDGSFQ LLYFIYSVLV IVSAALYLAG IEAYLAVMVF ALVLGWMNAL YFTRGLKLTG
     TYSIMIQKIL FKDLFRFLLV YLLFMIGYAS ALVSLLNPCA NLKVCDEDHA NCTVPTYPSC
     RDSETFSTFL LDLFKLTIGM GDLEMLSSTK YPVVFIILLV TYIILTFVLL LNMLIALMGE
     TVGQVSKESK HIWKLQWATT ILDIERSFPV FLRKAFRSGE MVTVGKSSDG TPDRRWCFRV
     DEVNWSHWNQ NLGIINEDPG KNENYQYYGF SHTVGRLRRD RWSSVVPRVV ELNKNSNPDE
     VVVPLDNVGN PSCDGHQQSY PPKWRTDDAP L
//
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