ID E1BCR0_BOVIN Unreviewed; 630 AA.
AC E1BCR0;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 3.
DT 27-MAR-2024, entry version 80.
DE SubName: Full=SHC adaptor protein 4 {ECO:0000313|Ensembl:ENSBTAP00000015489.6};
GN Name=SHC4 {ECO:0000313|Ensembl:ENSBTAP00000015489.6,
GN ECO:0000313|VGNC:VGNC:106925};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000015489.6, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000015489.6, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000015489.6,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000015489.6}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000015489.6};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; NP_001192841.1; NM_001205912.1.
DR AlphaFoldDB; E1BCR0; -.
DR SMR; E1BCR0; -.
DR STRING; 9913.ENSBTAP00000015489; -.
DR PaxDb; 9913-ENSBTAP00000015489; -.
DR Ensembl; ENSBTAT00000015489.6; ENSBTAP00000015489.6; ENSBTAG00000022583.5.
DR GeneID; 524734; -.
DR KEGG; bta:524734; -.
DR CTD; 399694; -.
DR VEuPathDB; HostDB:ENSBTAG00000022583; -.
DR VGNC; VGNC:106925; SHC4.
DR eggNOG; KOG3697; Eukaryota.
DR GeneTree; ENSGT00950000182870; -.
DR HOGENOM; CLU_029532_0_0_1; -.
DR InParanoid; E1BCR0; -.
DR OMA; QLRSEDC; -.
DR OrthoDB; 2903566at2759; -.
DR TreeFam; TF315807; -.
DR Proteomes; UP000009136; Chromosome 10.
DR Bgee; ENSBTAG00000022583; Expressed in spermatocyte and 54 other cell types or tissues.
DR ExpressionAtlas; E1BCR0; baseline.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0019904; F:protein domain specific binding; IEA:Ensembl.
DR GO; GO:0030971; F:receptor tyrosine kinase binding; IBA:GO_Central.
DR GO; GO:0006915; P:apoptotic process; IEA:Ensembl.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:Ensembl.
DR GO; GO:0010468; P:regulation of gene expression; IEA:Ensembl.
DR GO; GO:0048863; P:stem cell differentiation; IEA:Ensembl.
DR GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IBA:GO_Central.
DR CDD; cd01209; PTB_Shc; 1.
DR CDD; cd09925; SH2_SHC; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR006019; PID_Shc-like.
DR InterPro; IPR006020; PTB/PI_dom.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR035676; SHC_SH2.
DR PANTHER; PTHR10337; SHC TRANSFORMING PROTEIN; 1.
DR PANTHER; PTHR10337:SF12; SHC-TRANSFORMING PROTEIN 4; 1.
DR Pfam; PF00640; PID; 1.
DR Pfam; PF00017; SH2; 1.
DR PRINTS; PR00401; SH2DOMAIN.
DR PRINTS; PR00629; SHCPIDOMAIN.
DR SMART; SM00462; PTB; 1.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR PROSITE; PS01179; PID; 1.
DR PROSITE; PS50001; SH2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191}.
FT DOMAIN 189..349
FT /note="PID"
FT /evidence="ECO:0000259|PROSITE:PS01179"
FT DOMAIN 526..617
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT REGION 40..66
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 118..176
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 475..515
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 40..57
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 122..136
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 630 AA; 68633 MW; 0D75B9CFAE6026C3 CRC64;
MRERGQDSLA GLVLYVGLFG HPGMLHRAKY SRFRNESITS LDEGSPGVST GSKGSPQPPY
PTLAPHLPAE DAALASQESP TPLCTLIPRM ASVKLANPAT LLSLKNFCLG TKEVPRLKLQ
ESQDPAPSSP ASPETSLNRA VPAPPPQRDP LGHRATSLTP DACPLPGPGE PTPRNRQDRH
FVQHLLGLGM NYYVRYMGCI EVLQSMRSLD FGMRTQVTRE AISRLCEAVP GANGAIKKRK
PPAKFLSTVL GKSNLQFSGM NIKLTISTCS LTLMNLDNQQ IIANHHMQSI SFASGGDPDT
TDYVAYVAKD PVNQRACHIL ECRNGMAQDV ISTIGQAFEL RFKQYLKNPS LNTSCESEEV
PVDGHAEERE DHEYYNEIPG KQPPAGGVSD VRIKVQVTEQ MAYCPIRCEK LCYLPGSSKS
SSMYENCLEQ SRAIGNAHER GVPSQREASL MKHSCGADLF DDPCYINTQA LRSTLGPAGN
QSSPHPLGSP WPQETAPETV QPGATAQPAS SHSLPHIKQQ LRNEDCYHGK LSRKAAESLL
VKDGDFLVRE SATSPGQYVL SGLQGGQAKH LLLVDPEGKV RTKDHVFDNV GHLIRYHMDN
SLPIISSGSE VSLKQPVRKD NNPGLLHSNK
//
