ID E1BGJ0_BOVIN Unreviewed; 4545 AA.
AC E1BGJ0;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 3.
DT 27-MAR-2024, entry version 100.
DE SubName: Full=LDL receptor related protein 1 {ECO:0000313|Ensembl:ENSBTAP00000017556.6};
GN Name=LRP1 {ECO:0000313|Ensembl:ENSBTAP00000017556.6,
GN ECO:0000313|VGNC:VGNC:30986};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000017556.6, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000017556.6, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000017556.6,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000017556.6}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000017556.6};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the LDLR family.
CC {ECO:0000256|ARBA:ARBA00009939}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR SMR; E1BGJ0; -.
DR CORUM; E1BGJ0; -.
DR STRING; 9913.ENSBTAP00000017556; -.
DR PaxDb; 9913-ENSBTAP00000017556; -.
DR Ensembl; ENSBTAT00000017556.6; ENSBTAP00000017556.6; ENSBTAG00000010830.6.
DR VEuPathDB; HostDB:ENSBTAG00000010830; -.
DR VGNC; VGNC:30986; LRP1.
DR eggNOG; KOG1215; Eukaryota.
DR GeneTree; ENSGT00940000157899; -.
DR HOGENOM; CLU_000085_2_1_1; -.
DR InParanoid; E1BGJ0; -.
DR OMA; TEQLYWI; -.
DR TreeFam; TF315253; -.
DR Reactome; R-BTA-2168880; Scavenging of heme from plasma.
DR Reactome; R-BTA-975634; Retinoid metabolism and transport.
DR Proteomes; UP000009136; Chromosome 5.
DR Bgee; ENSBTAG00000010830; Expressed in omental fat pad and 106 other cell types or tissues.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:Ensembl.
DR GO; GO:0005769; C:early endosome; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IDA:AgBase.
DR GO; GO:0043235; C:receptor complex; IEA:Ensembl.
DR GO; GO:0016964; F:alpha-2 macroglobulin receptor activity; IEA:Ensembl.
DR GO; GO:0034185; F:apolipoprotein binding; IBA:GO_Central.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0048306; F:calcium-dependent protein binding; IPI:GO_Central.
DR GO; GO:0038024; F:cargo receptor activity; IBA:GO_Central.
DR GO; GO:0032050; F:clathrin heavy chain binding; IEA:Ensembl.
DR GO; GO:0044877; F:protein-containing complex binding; IEA:Ensembl.
DR GO; GO:0150094; P:amyloid-beta clearance by cellular catabolic process; IBA:GO_Central.
DR GO; GO:0150093; P:amyloid-beta clearance by transcytosis; IBA:GO_Central.
DR GO; GO:0006909; P:phagocytosis; IBA:GO_Central.
DR GO; GO:0045807; P:positive regulation of endocytosis; IEA:Ensembl.
DR GO; GO:1905167; P:positive regulation of lysosomal protein catabolic process; IEA:Ensembl.
DR GO; GO:1903078; P:positive regulation of protein localization to plasma membrane; IEA:Ensembl.
DR GO; GO:0006898; P:receptor-mediated endocytosis; IBA:GO_Central.
DR CDD; cd00054; EGF_CA; 1.
DR CDD; cd00112; LDLa; 31.
DR Gene3D; 4.10.1220.10; EGF-type module; 1.
DR Gene3D; 2.10.25.10; Laminin; 13.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 30.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 8.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR032485; LRP1-like_beta_prop.
DR PANTHER; PTHR22722:SF5; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 1B; 1.
DR PANTHER; PTHR22722; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED; 1.
DR Pfam; PF12662; cEGF; 1.
DR Pfam; PF16472; DUF5050; 1.
DR Pfam; PF07645; EGF_CA; 2.
DR Pfam; PF14670; FXa_inhibition; 3.
DR Pfam; PF00057; Ldl_recept_a; 29.
DR Pfam; PF00058; Ldl_recept_b; 11.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00181; EGF; 26.
DR SMART; SM00179; EGF_CA; 7.
DR SMART; SM00192; LDLa; 31.
DR SMART; SM00135; LY; 35.
DR SUPFAM; SSF57196; EGF/Laminin; 5.
DR SUPFAM; SSF57184; Growth factor receptor domain; 3.
DR SUPFAM; SSF57424; LDL receptor-like module; 30.
DR SUPFAM; SSF63825; YWTD domain; 8.
DR PROSITE; PS00010; ASX_HYDROXYL; 1.
DR PROSITE; PS00022; EGF_1; 3.
DR PROSITE; PS01186; EGF_2; 3.
DR PROSITE; PS50026; EGF_3; 6.
DR PROSITE; PS01187; EGF_CA; 2.
DR PROSITE; PS01209; LDLRA_1; 15.
DR PROSITE; PS50068; LDLRA_2; 31.
DR PROSITE; PS51120; LDLRB; 25.
PE 1: Evidence at protein level;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Proteomics identification {ECO:0007829|PeptideAtlas:E1BGJ0};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..4545
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018662490"
FT TRANSMEM 4425..4445
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 335..378
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 379..422
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 571..613
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 614..659
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 660..710
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 711..754
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1309..1355
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1356..1398
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1399..1445
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1446..1490
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1627..1669
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1670..1713
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1714..1753
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1934..1976
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1977..2019
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 2020..2063
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 2064..2107
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 2344..2388
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 2389..2431
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DOMAIN 2982..3017
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REPEAT 3069..3113
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 3114..3156
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 3157..3200
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 3201..3243
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 3971..4013
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 4014..4057
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DOMAIN 4197..4230
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 4233..4269
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 4270..4302
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 4305..4341
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 4376..4410
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 854..866
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 861..879
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 895..907
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 902..920
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 936..948
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 943..961
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 984..1002
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 996..1011
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1015..1027
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1022..1040
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1082..1097
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1125..1140
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2532..2550
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2566..2578
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2573..2591
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2585..2600
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2605..2617
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2612..2630
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2624..2639
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2673..2688
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2696..2708
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2703..2721
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2715..2730
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2734..2746
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2741..2759
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2818..2830
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2825..2843
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2858..2870
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2912..2930
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2924..2939
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2986..2996
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 3335..3347
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3342..3360
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3375..3387
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3382..3400
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3394..3409
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3434..3449
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3537..3549
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3544..3562
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3556..3571
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3576..3588
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3583..3601
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3595..3610
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3614..3626
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3621..3639
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3633..3648
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3655..3667
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3662..3680
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3717..3732
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3750..3768
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3762..3777
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 4201..4211
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 4237..4247
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 4259..4268
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 4273..4283
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 4309..4319
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 4331..4340
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 4378..4388
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 4400..4409
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 4545 AA; 504916 MW; C4E428B53348453A CRC64;
MLTPPLLLLL PLLSALVAAA VDVPKTCSPK QFACRDQITC ISKGWRCDGE RDCPDGSDEA
PEICPQSKAQ RCQPNEHNCL GTELCILMSR LCNGVQDCAD GSDEGSHCRE QRGQCSHLGC
QHHCVPTLNG PTCYCNNSFQ LQADGKTCKD FDECSVYGTC SQLCTNTDGS FTCGCVEGYL
LQPDNRSCKA KNEPVDRPPV LLIANSQNIL ATYLSGAQVS TITPTSTRQT TAMDFSYANE
TVCWVHVGDS AAQTQLKCAR MPGLKGFVDE YTINISLSLH HVEQMAIDWL TGNFYFVDDI
DDRIFVCNRN GDTCVTLLDL ELYNPKGIAL DPAMGKVFFT DYGQIPKVER CDMDGQNRTK
LVDSKIVFPH GITLDLVSRL VYWADAYLDY IEVVDYEGKG RQTIIQGILI EHLYGLTVFE
NYLYATNSDN ANAQQKTSVI RVNRFNSTDY QVVTRVDKGG ALHIYHQRRQ PRVRSHACEN
DQYGKPGGCS DICLLANSHK ARTCRCRSGF SLGSDGKSCK KPEHELFLVY GKGRPGIIRG
MDMGAKVPDE HMIPIENLMN PRALDFHAET GFIYFADTTS YLIGRQKIDG TERETILKDG
IHNVEGVAVD WMGDNLYWTD DGPKKTISVA RLEKAAQTRK TLIEGKMTHP RAIVVDPLNG
WMYWTDWEED PKDSRRGRLE RAWMDGSHRD IFVTSKTVLW PNGLSLDIPA GRLYWVDAFY
DRIETILLNG TDRKIVYEGP ELNHAFGLCH HGNYLFWTEY RSGSVYRLER GTGGAAPIVT
LLRSERPPIF EIRMYDAQQQ QVGTNKCRVN NGGCSSLCLA TPGSRQCACA EDQVLDADGV
TCLANPSYVP PPQCQPGEFA CSNSRCIQER WKCDGDNDCL DNSDEAPALC HQHTCPSDRF
KCENNRCIPN RWLCDGDNDC GNSEDESNAT CSARTCPPNQ FSCASGRCIP ISWTCDLDDD
CGDRSDESAS CAYPTCFPLT QFTCNNGRCI NINWRCDNDN DCGDNSDEAG CSHSCSSTQF
KCNSGRCIPE HWTCDGDNDC GDYSDETHAN CTNQATRPPG GCHNDEFQCR LDGLCIPLRW
RCDGDTDCMD SSDEKSCEGV THVCDPNVKF GCKDSARCIS KAWVCDGDSD CEDNSDEENC
ESLACRPPSH PCANNTSVCL PPDKLCDGND DCGDGSDEGE LCDQCSLNNG GCSHNCSVAP
GEGIVCSCPL GMELGPDNHT CQIQSYCAKH LKCSQKCDQN KFSVKCSCYE GWVLEPDGES
CRSLDPFKPF IIFSNRHEIR RIDLHKGDYS VLVPGLRNTI ALDFHLSQSA LYWTDVVEDK
IYRGKLLDNG ALTSFEVVIQ YGLATPEGLA VDWIAGNIYW VESNLDQIEV AKLDGTLRTT
LLAGDIEHPR AIALDPRDGI LFWTDWDASL PRIEAASMSG AGRRTIHRET GSGGWPNGLT
VDYLEKRILW IDARSDAIYS ARYDGSGHME VLRGHEFLSH PFAVTLYGGE VYWTDWRTNT
LAKANKWTGH NVTVVQRTNT QPFDLQVYHP SRQPMAPNPC EANGGRGPCS HLCLIDYNRT
VSCACPHLMK LHKDNTTCYE FKKFLLYARQ MEIRGVDLDA PYYNYIISFT VPDIDNVTVL
DYDAREQRVY WSDVRTQAIK RAFINGTGVE TVVSADLPNA HGLAVDWVSR NLFWTSYDTN
KKQINVARLD GSFKNAVVQG LEQPHGLVVH PLRGKLYWTD GDNISMANMD GSNRTLLFSG
QRGPVGLAID FPESKLYWIS SKNHTINRCN LDGSELEVID AMRNQLGKAT ALAIMGDKLW
WADQVSEKMG TCNKADGSGS VVLRNSTTLV MHMKVYDESI QLDHEGTNPC SVNNGDCSQL
CLPTSETTRS CMCTAGYSLR SGQQACEGVG SFLLYSVHEG IRGIPLDPND KSDALVPVSG
TSLAVGIDFH AENDTIYWVD MGLSTISRAK RDQTWREDVV TNGIGRVEGI AVDWIAGNIY
WTDQGFDVIE VARLNGSFRY VVISQGLDKP RAITVHPEKG YLFWTEWGQY PRIERSRLDG
SERVVLVNVS ISWPNGISVD YQDGKLYWCD ARTDKIERID LETGEDREVV LSSNNMDMFS
VSVFEEFIYW SDRTHANGSI KRGSKDNATD SVPLRTGIGV QLKDIKVFNR DRQKGTNVCA
VDNGGCQQLC LYRGNGQRAC ACAHGMLAED GASCREYAGY LLYSERTILK SVHLSDERNL
NAPVQPFEDP EHMKNVIALA FDYRAGTSPG TPNRIFFSDI HFGNIQQIND DGSGRTTIVE
NVGSVEGLAY HRGWDTLYWT SYTTSTITRH TVDQTRPGAF ERETVITMSG DDHPRAFVLD
ECQNLMFWTN WNEQHPSIMR AALSGANVLT LIEKDIRTPN GLAIDHRAEK LYFSDATLDK
IERCEYDGSH RYVILKSEPV HPFGLAVYGE HIFWTDWVRR AVQRANKYVG SDMKLLRVDI
PQQPMGIIAV ANDTNSCELS PCRINNGGCQ DLCLLTHQGH VNCSCRGGRI LQDDFTCQAV
NSSCRAQDEF ECANGECINF GLTCDGVSHC KDKSDEKPSY CNTRRCKKTF RQCNNGRCVS
NMLWCNGADD CGDGSDEIPC NKTACGVGEF RCRDGTCIGN SSRCNQFVDC EDASDEMNCS
ATDCSSYFRL GVKGVRFQPC ERTSLCYAPS WVCDGANDCG DYSDERDCPG VKRPRCPLNY
FACPSGRCIP MSWTCDKEDD CEHGEDETHC NKFCSEAQFE CQNHRCISKQ WLCDGSDDCG
DGSDEAAHCE GKTCGPGSFS CPGTHVCVPE RWLCDGDKDC ADGADESVAA GCLYNSTCDD
REFMCQNRQC IPKHFMCDHD RDCADGSDES PECEYPTCGP NEFRCANGRC LSSRQWECDG
ENDCHDQSDE APKNPHCTSP EHKCNASSQF LCSSGRCVAE ALLCNGQDDC GDGSDERGCH
INECLSHKLS GCSQDCEDLK IGFKCRCRPG FRLKDDGRTC ADMDECSTTF PCSQRCINTH
GSYKCLCVEG YAPRGGDPHS CKAVTDEEPF LIFANRYYLR KLNLDGSNYT LLKQGLNNAV
ALDFDYREQM IYWTDVTTQG SMIRRMHLNG SNVQVLHRTG LSNPDGLAVD WVGGNLYWCD
KGRDTIEVSK LNGAYRTVLV SSGLREPRAL VVDVQNGYLY WTDWGDHSLI GRIGMDGSSR
SVIVDTKITW PNGLTLDYVT ERIYWADARE DYIEFASLDG SNRHVVLSQD IPHIFALTLF
EDYVYWTDWE TKSINRAHKT TGTNKTLLIS TLHRPMDLHV FHALRQPDAV PNHPCKVNNG
GCSNLCLLSP GGGHKCACPT NFYLGGDGRN CVSNCTASQF VCKNDKCIPF WWKCDTEDDC
GDHSDEPPDC PEFKCRPGQF QCSTGICTNP AFICDGDNDC QDNSDEANCD IHVCLPSQFK
CTNTNRCIPG IFRCNGQDNC GDGEDERDCP EVTCAPNQFQ CSITKRCIPR VWVCDRDNDC
VDGSDEPANC TQMTCGVDEF RCKDSGRCIP ARWKCDGEDD CGDGSDEPKE ECDERTCEPY
QFRCKNNRCV PGRWQCDYDN DCGDNSDEES CTPRPCSESE FSCANGRCIA GRWKCDGDHD
CADGSDEKDC TPRCDMDQFQ CKSGHCIPLR WRCDADADCM DGSDEEACGT GVRTCPLDEF
QCNNTLCKPL AWKCDGEDDC GDNSDENPEE CARFVCPPNR PFRCKNDRVC LWIGRQCDGT
DNCGDGTDEE DCEPPTAQTS HCKDKKEFLC RNQRCLSSSL RCNMFDDCGD GSDEEDCSMD
PKLTSCATNA SICGDEARCV RTEKAAYCAC RTGFHTVPGQ PGCQDINECL RFGTCSQLCN
NTKGGHLCSC ARNFMKTHNT CKAEGSEYQV LYIADDNEIR SLFPSHPHSA YEQAFQGDES
VRIDAMDVHV KAGRVYWTNW HTGTISYRSL PPAAPPTTSN RHRRQIDRGV THLNISGLKM
PRGIAIDWVA GNVYWTDSGR DVIEVAQMKG ENRKTLISGM IDEPHAIVVD PLRGTMYWSD
WGNHPKIETA AMDGTLRETL VQDNIQWPTG LAVDYHNERL YWADAKLSVI GSIRLNGTDP
IVAADSKRGL SHPFSIDVFE DYIYGVTYIN NRVFKIHKFG HSPLINLTGG LSHASDVVLY
HQHKQPEVTN PCDRKKCEWL CLLSPSGPVC TCPNGKRLDN GTCVAVPSPT PPPDAPRPGT
CNLQCFNGGS CFLNARRQPK CRCQPRYTGD KCELDQCWEH CRNGGTCAAS PSGMPTCRCP
TGFTGPKCTQ QVCAGYCANN STCTVNQGNQ PQCRCLPGFL GDRCQYRQCS DYCENFGTCQ
MAADGSRQCR CTAYFEGPRC EVNKCSRCLD GACVVNKQSG DVTCNCSDGR VAPSCLTCIG
HCSNGGSCTM NSKMMPECQC PPHMAGPRCE EQVVGQQQPG HVASILIPLL LLLLMLLVAG
VVFWYKRRVR GAKGFQHQRM TNGAMNVEIG NPTYKMYEGG EPDDVGGLLD ADFALDPDKP
TNFTNPVYAT LYMGGHGSRH SLASTDEKRE LLGRGPEDEI GDPLA
//
