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Database: UniProt
Entry: E1BHM6_BOVIN
LinkDB: E1BHM6_BOVIN
Original site: E1BHM6_BOVIN 
ID   E1BHM6_BOVIN            Unreviewed;      1783 AA.
AC   E1BHM6;
DT   02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 2.
DT   05-JUL-2017, entry version 53.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=SCN11A {ECO:0000313|Ensembl:ENSBTAP00000022822};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000022822, ECO:0000313|Proteomes:UP000009136};
RN   [1] {ECO:0000313|Ensembl:ENSBTAP00000022822, ECO:0000313|Proteomes:UP000009136}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000022822,
RC   ECO:0000313|Proteomes:UP000009136};
RX   PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42;
RA   Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C.,
RA   Puiu D., Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S.,
RA   Marcais G., Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.;
RT   "A whole-genome assembly of the domestic cow, Bos taurus.";
RL   Genome Biol. 10:R42.01-R42.10(2009).
RN   [2] {ECO:0000313|Ensembl:ENSBTAP00000022822}
RP   IDENTIFICATION.
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000022822};
RG   Ensembl;
RL   Submitted (MAR-2016) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSBTAP00000022822}.
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DR   EMBL; DAAA02053657; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; DAAA02053658; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9913.ENSBTAP00000022822; -.
DR   PaxDb; E1BHM6; -.
DR   Ensembl; ENSBTAT00000022822; ENSBTAP00000022822; ENSBTAG00000017174.
DR   eggNOG; ENOG410KCTY; Eukaryota.
DR   eggNOG; COG1226; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   InParanoid; E1BHM6; -.
DR   OMA; CYQIVKH; -.
DR   OrthoDB; EOG091G00FK; -.
DR   TreeFam; TF323985; -.
DR   Proteomes; UP000009136; Chromosome 22.
DR   Bgee; ENSBTAG00000017174; -.
DR   GO; GO:0044299; C:C-fiber; IEA:Ensembl.
DR   GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IBA:GO_Central.
DR   GO; GO:0086010; P:membrane depolarization during action potential; IBA:GO_Central.
DR   GO; GO:0019228; P:neuronal action potential; IBA:GO_Central.
DR   GO; GO:0051930; P:regulation of sensory perception of pain; IEA:Ensembl.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR028821; Na_channel_a11su.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   PANTHER; PTHR10037:SF229; PTHR10037:SF229; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   PRINTS; PR00170; NACHANNEL.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000009136};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    131    150       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    162    184       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    196    214       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    235    253       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    259    278       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    375    394       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    580    598       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    610    633       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    703    726       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    784    810       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1053   1071       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1092   1114       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1120   1142       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1163   1196       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1283   1306       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1356   1379       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1399   1417       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1429   1447       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1484   1512       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1532   1555       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1576   1602       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      128    411       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      580    818       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      828   1047       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1051   1314       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1363   1612       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      412    436       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1783 AA;  204494 MW;  2FFC16DA4C66F86C CRC64;
     MDDRCYPVIF PDGRNFRPFT PDSLAAIKKR IAIQKEKNKS KDRKAAECEP RPQLDLKVSR
     KLPKLYGDIP RDLIAKPLED LDPFYHNHKT FMVLNKKRTI YRFSAKRALF ILGPFNSIRS
     LAIRISVHSL FSMFIICTVI INCVFMALAH QKSSIDVKTD HAEYVFLGIY LFEALVKILA
     RGFILDEFSF LRDPWNWLDS IVIATAFVSY SPYINDSSFS LSSLRTFRVF RALKAISVIS
     GLKVIVGALL HSVKKLVDVM ILALFCLSIF ALVGQQLFMG NLRYKCVSNS CKHHYQDYYQ
     DYCFKKEEST EFKMCGMWMG NRACPEQYEC RDSHKNPDYN YTNFDNFGWS FLAMFRLMTQ
     DSWEKLYRQT VRTSGLISVL FFVVVIFLGS FYLVNLTLAV VTMTYEEQNK NVAAETEAKE
     KMFQEAQQLL KEEKEALVAM GIDRSSLNSL EASSFSPKKR KLFGSKKRKS FFLRKSGKDQ
     IPGSDSDEDS SKKPHLLEQT KRLSQNLSVD HCDEHGDSFQ RQRALSAVSI LTITMQEQEK
     SQEPCLPCGE NLASRYLVWD CSPWWLDIKK VLRTVMTDPF TELAITICII INTVFLAMEH
     YKMDQNFENI LYTGNLVFTG IFMAEMCLKI IALDPYHYFR RGWNIFDSVV ALLSLADVIL
     NHIVSGKSWI SFRSLRVLRV FKLAKSWPTL STLIKIIGHS VGALGNLTVV LAIVVFIFSV
     VGMQLFGSKF NNRKNNLKSC DPEVLCLRRW HMGDFYHSFL VVFRILCGEW IENMWECMQE
     ANPTLCVIVF LSIMVIGKLV VLNLFIALLL NSFSNEERNG HLEGKVKKTK IQIALDRFCR
     AFCFVIHTLE HFFRKHCRKR HLSKQKEVTE DPGGKIKDII PLVTGMRKGP EIWEEFGVLT
     SVPMALYDRT WLAPLAEEED DAEPPGEDKA QAVTQPEAGK QASEVHQKSK DLTSPGIQSV
     EIDLFSGDDP PMSIQNLRKK SDAASVLSEC STIGPQDPFM RVLEMIPKKE PERCLPEGLN
     CCSLCHTVDK RKSSWITWWS LRKICYQIVK HSWFESFIIF VILLSSGALV FEDINLDKQP
     KIQELLKCTD TIFTYIFILE MGLKWVAFGF RKYFTSVWCW LDFVIVIVSV TSLIDLMGLK
     SFRILRALRP LRALSQFEGM KVVVYALIGA IPAILNVLLV CLIFWLIFCI LGVSLFSGRF
     GRCVNATDVK SVIDYNIVAN RNQCESGHFY WDTPDVNFDN VLMAYLALLQ VATFKGWMDI
     MYAAVDSTEE GQQPQFEARS SMYLYFVVFI IFGSFFTLNL FTGVIIDNFN QQQKKISGQD
     VFLTEEQKKY YNAMKKLGSK KPQRPIPRPQ NKCQGFVFDL VTHQVFDIII IILILLNMLS
     MMAETHKQSE TMKHLLESLN MAFVVIFAIE CFIKIFALRQ YYFANGWNLF DCVIVLLSIV
     SSVVSALKTQ AQIPFPPTLF RMVRLVRIGR ILRLVRAARR IRTLLFALMM SLPSLFNIGL
     LLFLVMFIYA IFGMNSFRKV KEESGIDDIF NFQTFTSSML CLFQITTTAG WDALLSPMLK
     SNKSCDPKTE SCHLSTIAII YFVTYIIISS LIVVNMYIAV ILENFNVATE ESEDPLGEDD
     FEMFYEVWEK FDPEATQFIK YSALSDFADA LPEPLRVAKP NKYQFLVMDL PMVSGERLHC
     LDILFAFTTR VLGESSGLDS MKAAIEEKFM EANPFKKLYE PIVTTTKRNE EERCAAAVIQ
     KAFRKYMLKT RCTLKDRPHS TLQTLSNGDL PSSGVAEGKV HYD
//
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