ID E1BHR0_BOVIN Unreviewed; 362 AA.
AC E1BHR0;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 3.
DT 24-JAN-2024, entry version 73.
DE SubName: Full=Pregnancy-associated glycoprotein 10 {ECO:0000313|Ensembl:ENSBTAP00000044246.4};
GN Name=PAG10 {ECO:0000313|Ensembl:ENSBTAP00000044246.4};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000044246.4, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000044246.4, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000044246.4,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000044246.4}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000044246.4};
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space
CC {ECO:0000256|ARBA:ARBA00004239}.
CC -!- SIMILARITY: Belongs to the peptidase A1 family.
CC {ECO:0000256|ARBA:ARBA00007447, ECO:0000256|RuleBase:RU000454}.
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DR AlphaFoldDB; E1BHR0; -.
DR Ensembl; ENSBTAT00000047007.4; ENSBTAP00000044246.4; ENSBTAG00000004116.6.
DR VEuPathDB; HostDB:ENSBTAG00000004116; -.
DR GeneTree; ENSGT00940000153747; -.
DR Proteomes; UP000009136; Chromosome 29.
DR Bgee; ENSBTAG00000004116; Expressed in placenta and 3 other cell types or tissues.
DR ExpressionAtlas; E1BHR0; baseline and differential.
DR GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 6.10.140.60; -; 1.
DR Gene3D; 2.40.70.10; Acid Proteases; 2.
DR InterPro; IPR001461; Aspartic_peptidase_A1.
DR InterPro; IPR001969; Aspartic_peptidase_AS.
DR InterPro; IPR012848; Aspartic_peptidase_N.
DR InterPro; IPR033121; PEPTIDASE_A1.
DR InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR PANTHER; PTHR47966; BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED; 1.
DR PANTHER; PTHR47966:SF49; PEPSIN A-5; 1.
DR Pfam; PF07966; A1_Propeptide; 1.
DR Pfam; PF00026; Asp; 1.
DR PRINTS; PR00792; PEPSIN.
DR SUPFAM; SSF50630; Acid proteases; 1.
DR PROSITE; PS00141; ASP_PROTEASE; 2.
DR PROSITE; PS51767; PEPTIDASE_A1; 1.
PE 3: Inferred from homology;
KW Aspartyl protease {ECO:0000256|RuleBase:RU000454};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|PIRSR:PIRSR601461-2};
KW Hydrolase {ECO:0000256|RuleBase:RU000454};
KW Protease {ECO:0000256|RuleBase:RU000454};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136}.
FT DOMAIN 54..359
FT /note="Peptidase A1"
FT /evidence="ECO:0000259|PROSITE:PS51767"
FT ACT_SITE 72
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
FT ACT_SITE 253
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
FT DISULFID 85..90
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
FT DISULFID 244..248
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
FT DISULFID 286..319
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
SQ SEQUENCE 362 AA; 40363 MW; 814287701EF81291 CRC64;
IPLRQMKTMR ETLRERNLLT NFSEEHPYNL SQKAANDQNI IYHHPLRSYK DFSYIGNINI
GTPPQEFQVL FDTGSSSLWV PSIYCQSSSC YKHNSFVPCN SSTFKATNKI FNTNYTATSI
KGYLVYDTVR IGNLVSVAQP FGLSLKEFGF DDVPFDGILG LGYPRRTITG ANPIFDNLWK
QGVISEPVFA FYLSSQKENG SVVMFGGVNR AYYKGELNWV PVSQVGSWHI NIDSISMNGT
VVACKRGCQA LLDTGTAFLR GPRGSVSKIQ KLIHARPIDR EHVVSCQAIG TLPPAVFTIN
GIDYPVPAQA YIQRLHNSCT LLYGSSEQAN GLKTWILGEV FLRLYFSVFD RGNNRIGLAP
AV
//