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Database: UniProt
Entry: E1BHR0_BOVIN
LinkDB: E1BHR0_BOVIN
Original site: E1BHR0_BOVIN 
ID   E1BHR0_BOVIN            Unreviewed;       362 AA.
AC   E1BHR0;
DT   02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 3.
DT   24-JAN-2024, entry version 73.
DE   SubName: Full=Pregnancy-associated glycoprotein 10 {ECO:0000313|Ensembl:ENSBTAP00000044246.4};
GN   Name=PAG10 {ECO:0000313|Ensembl:ENSBTAP00000044246.4};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000044246.4, ECO:0000313|Proteomes:UP000009136};
RN   [1] {ECO:0000313|Ensembl:ENSBTAP00000044246.4, ECO:0000313|Proteomes:UP000009136}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000044246.4,
RC   ECO:0000313|Proteomes:UP000009136};
RA   Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA   Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA   Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT   "ARS-UCD1.2.";
RL   Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSBTAP00000044246.4}
RP   IDENTIFICATION.
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000044246.4};
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space
CC       {ECO:0000256|ARBA:ARBA00004239}.
CC   -!- SIMILARITY: Belongs to the peptidase A1 family.
CC       {ECO:0000256|ARBA:ARBA00007447, ECO:0000256|RuleBase:RU000454}.
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DR   AlphaFoldDB; E1BHR0; -.
DR   Ensembl; ENSBTAT00000047007.4; ENSBTAP00000044246.4; ENSBTAG00000004116.6.
DR   VEuPathDB; HostDB:ENSBTAG00000004116; -.
DR   GeneTree; ENSGT00940000153747; -.
DR   Proteomes; UP000009136; Chromosome 29.
DR   Bgee; ENSBTAG00000004116; Expressed in placenta and 3 other cell types or tissues.
DR   ExpressionAtlas; E1BHR0; baseline and differential.
DR   GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 6.10.140.60; -; 1.
DR   Gene3D; 2.40.70.10; Acid Proteases; 2.
DR   InterPro; IPR001461; Aspartic_peptidase_A1.
DR   InterPro; IPR001969; Aspartic_peptidase_AS.
DR   InterPro; IPR012848; Aspartic_peptidase_N.
DR   InterPro; IPR033121; PEPTIDASE_A1.
DR   InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR   PANTHER; PTHR47966; BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED; 1.
DR   PANTHER; PTHR47966:SF49; PEPSIN A-5; 1.
DR   Pfam; PF07966; A1_Propeptide; 1.
DR   Pfam; PF00026; Asp; 1.
DR   PRINTS; PR00792; PEPSIN.
DR   SUPFAM; SSF50630; Acid proteases; 1.
DR   PROSITE; PS00141; ASP_PROTEASE; 2.
DR   PROSITE; PS51767; PEPTIDASE_A1; 1.
PE   3: Inferred from homology;
KW   Aspartyl protease {ECO:0000256|RuleBase:RU000454};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW   ECO:0000256|PIRSR:PIRSR601461-2};
KW   Hydrolase {ECO:0000256|RuleBase:RU000454};
KW   Protease {ECO:0000256|RuleBase:RU000454};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009136}.
FT   DOMAIN          54..359
FT                   /note="Peptidase A1"
FT                   /evidence="ECO:0000259|PROSITE:PS51767"
FT   ACT_SITE        72
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
FT   ACT_SITE        253
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
FT   DISULFID        85..90
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
FT   DISULFID        244..248
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
FT   DISULFID        286..319
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
SQ   SEQUENCE   362 AA;  40363 MW;  814287701EF81291 CRC64;
     IPLRQMKTMR ETLRERNLLT NFSEEHPYNL SQKAANDQNI IYHHPLRSYK DFSYIGNINI
     GTPPQEFQVL FDTGSSSLWV PSIYCQSSSC YKHNSFVPCN SSTFKATNKI FNTNYTATSI
     KGYLVYDTVR IGNLVSVAQP FGLSLKEFGF DDVPFDGILG LGYPRRTITG ANPIFDNLWK
     QGVISEPVFA FYLSSQKENG SVVMFGGVNR AYYKGELNWV PVSQVGSWHI NIDSISMNGT
     VVACKRGCQA LLDTGTAFLR GPRGSVSKIQ KLIHARPIDR EHVVSCQAIG TLPPAVFTIN
     GIDYPVPAQA YIQRLHNSCT LLYGSSEQAN GLKTWILGEV FLRLYFSVFD RGNNRIGLAP
     AV
//
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