ID E1BJ68_BOVIN Unreviewed; 135 AA.
AC E1BJ68;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 3.
DT 27-MAR-2024, entry version 78.
DE SubName: Full=Insulin like 5 {ECO:0000313|Ensembl:ENSBTAP00000005022.3};
GN Name=INSL5 {ECO:0000313|Ensembl:ENSBTAP00000005022.3,
GN ECO:0000313|VGNC:VGNC:55239};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000005022.3, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000005022.3, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000005022.3,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000005022.3}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000005022.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBUNIT: Heterodimer of a B chain and an A chain linked by two
CC disulfide bonds. {ECO:0000256|ARBA:ARBA00011207}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC ECO:0000256|RuleBase:RU000406}.
CC -!- SIMILARITY: Belongs to the insulin family.
CC {ECO:0000256|ARBA:ARBA00009034, ECO:0000256|RuleBase:RU000406}.
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DR RefSeq; NP_001193060.1; NM_001206131.1.
DR AlphaFoldDB; E1BJ68; -.
DR STRING; 9913.ENSBTAP00000005022; -.
DR PaxDb; 9913-ENSBTAP00000005022; -.
DR Ensembl; ENSBTAT00000005022.3; ENSBTAP00000005022.3; ENSBTAG00000003850.3.
DR GeneID; 613480; -.
DR KEGG; bta:613480; -.
DR CTD; 10022; -.
DR VEuPathDB; HostDB:ENSBTAG00000003850; -.
DR VGNC; VGNC:55239; INSL5.
DR eggNOG; ENOG502S9UT; Eukaryota.
DR GeneTree; ENSGT00940000154396; -.
DR HOGENOM; CLU_120043_1_0_1; -.
DR InParanoid; E1BJ68; -.
DR OMA; YVRTVVY; -.
DR OrthoDB; 4638109at2759; -.
DR TreeFam; TF333404; -.
DR Proteomes; UP000009136; Chromosome 3.
DR Bgee; ENSBTAG00000003850; Expressed in descending colon and 20 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0001664; F:G protein-coupled receptor binding; IBA:GO_Central.
DR GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR GO; GO:2000253; P:positive regulation of feeding behavior; IBA:GO_Central.
DR CDD; cd04365; IlGF_relaxin_like; 1.
DR Gene3D; 1.10.100.10; Insulin-like; 1.
DR InterPro; IPR016179; Insulin-like.
DR InterPro; IPR036438; Insulin-like_sf.
DR InterPro; IPR022353; Insulin_CS.
DR PANTHER; PTHR20968; ILGF DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR20968:SF2; INSULIN-LIKE PEPTIDE INSL5; 1.
DR Pfam; PF00049; Insulin; 1.
DR SMART; SM00078; IlGF; 1.
DR SUPFAM; SSF56994; Insulin-like; 1.
DR PROSITE; PS00262; INSULIN; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Secreted {ECO:0000256|ARBA:ARBA00022525, ECO:0000256|RuleBase:RU000406};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..135
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018594492"
FT DOMAIN 26..135
FT /note="Insulin-like"
FT /evidence="ECO:0000259|SMART:SM00078"
SQ SEQUENCE 135 AA; 15361 MW; D672AE5BAE5A596A CRC64;
MRGFIFMLFT FSVMLAISEA RREGSRKLCG SEYVRTVIYI CASSRWRRHA GALLQGQQAE
RGNHFQLPNE QEISEERAAH NLPKMDFAGE ESLQGEQLPT EGLWRSKKHL VMSRQDLQTL
CCTEGCSMSD LSTLC
//
