ID E1BJV9_BOVIN Unreviewed; 730 AA.
AC E1BJV9;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 3.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=Actin filament associated protein 1 {ECO:0000313|Ensembl:ENSBTAP00000016537.6};
GN Name=AFAP1 {ECO:0000313|Ensembl:ENSBTAP00000016537.6,
GN ECO:0000313|VGNC:VGNC:25706};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000016537.6, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000016537.6, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000016537.6,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000016537.6}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000016537.6};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; NP_001192973.1; NM_001206044.1.
DR AlphaFoldDB; E1BJV9; -.
DR SMR; E1BJV9; -.
DR STRING; 9913.ENSBTAP00000016537; -.
DR Ensembl; ENSBTAT00000016537.6; ENSBTAP00000016537.6; ENSBTAG00000012464.6.
DR GeneID; 534032; -.
DR KEGG; bta:534032; -.
DR CTD; 60312; -.
DR VEuPathDB; HostDB:ENSBTAG00000012464; -.
DR VGNC; VGNC:25706; AFAP1.
DR eggNOG; ENOG502QQI1; Eukaryota.
DR GeneTree; ENSGT00950000183067; -.
DR HOGENOM; CLU_014418_2_0_1; -.
DR InParanoid; E1BJV9; -.
DR OMA; DNMGLYD; -.
DR TreeFam; TF332622; -.
DR Proteomes; UP000009136; Chromosome 6.
DR Bgee; ENSBTAG00000012464; Expressed in myometrium and 106 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0042169; F:SH2 domain binding; IBA:GO_Central.
DR GO; GO:0017124; F:SH3 domain binding; IBA:GO_Central.
DR CDD; cd13306; PH1_AFAP; 1.
DR CDD; cd13307; PH2_AFAP; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR InterPro; IPR030113; AFAP.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR14338:SF8; ACTIN FILAMENT-ASSOCIATED PROTEIN 1; 1.
DR PANTHER; PTHR14338; ACTIN FILAMENT-ASSOCIATED PROTEIN 1 FAMILY MEMBER; 1.
DR Pfam; PF00169; PH; 2.
DR SMART; SM00233; PH; 2.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR PROSITE; PS50003; PH_DOMAIN; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136}.
FT DOMAIN 153..249
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 347..441
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 46..91
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 119..140
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 255..316
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 510..551
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 557..642
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 56..88
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 730 AA; 80775 MW; 723E09C6EC48D575 CRC64;
MEELIVELRL FLELLDHEYL TSTVREKKAV ITDILLRIQS SRGFEVKDHA TKPETPSSLP
APPQMPLPEI PQPWLPPDNG PPPLPTSSLP EGYYEEAVPL SPGKAPEYIT SNYDSDAMSS
SYESYDEEEE DGKGKKTRHQ WPSEEASMDL VKDAKICAFL LRKKRFGQWT KLLCVIKDTK
LLCYKSSKDQ QPQMELPLQG CNITYIPKDS KKKKHELKIT QQGTDPLVLA VQSKEQAEQW
LKVVREIYSG CSGPAELECP PPPSSPVHKV ELEKKLSSER PSSDGEGVAE NGIAMCNGKE
QVKRKKSSKS EAKGTVSKVT GKKITKIIGL GKKKPSTDEQ TSSAEEDVPT CGYLNVLSNS
RWRERWCRVK DNKLILHKDR ADLKTHIASI PLRGCEVIPG LDSKHPLTFR LLRNGQEVAV
LEASSSEDMG RWIGILLAET GSSTDPGALH YDYIDVEVSA SVIQTAKQTF CFMNRRVLST
NPYVGSTSNG YAHPSGTALH YDDVPCISGS SKGKKPPVAS NGVMGKGKAL SGQQKKADSA
AGVKRTPSNA DQYKYGKNRV EADAKRLQAK EEELLRRREG LRDRLAQLRK ERKGLRAAIE
VNTGRKTQVV LEEKLKKLEE ECKQKETERV NLELELTEVK ESLKKALAGG ITLGLAIEPR
SGTSSPQSPV FRHRTLENSP MSSCETSDAE GPLPVNSAAV LKKSRPAPGN SPCRGHVLRK
AKEWELKNGT
//
