ID E1BK71_BOVIN Unreviewed; 421 AA.
AC E1BK71;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 3.
DT 27-MAR-2024, entry version 81.
DE SubName: Full=Protein kinase C and casein kinase substrate in neurons 3 {ECO:0000313|Ensembl:ENSBTAP00000012594.6};
GN Name=PACSIN3 {ECO:0000313|Ensembl:ENSBTAP00000012594.6,
GN ECO:0000313|VGNC:VGNC:32544};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000012594.6, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000012594.6, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000012594.6,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000012594.6}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000012594.6};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; NP_001178349.1; NM_001191420.1.
DR RefSeq; XP_010811139.1; XM_010812837.2.
DR RefSeq; XP_010811140.1; XM_010812838.2.
DR RefSeq; XP_010811141.1; XM_010812839.2.
DR AlphaFoldDB; E1BK71; -.
DR SMR; E1BK71; -.
DR STRING; 9913.ENSBTAP00000012594; -.
DR SwissPalm; E1BK71; -.
DR PaxDb; 9913-ENSBTAP00000012594; -.
DR Ensembl; ENSBTAT00000012594.6; ENSBTAP00000012594.6; ENSBTAG00000009576.6.
DR GeneID; 535109; -.
DR KEGG; bta:535109; -.
DR CTD; 29763; -.
DR VEuPathDB; HostDB:ENSBTAG00000009576; -.
DR VGNC; VGNC:32544; PACSIN3.
DR eggNOG; KOG2856; Eukaryota.
DR GeneTree; ENSGT00950000182973; -.
DR HOGENOM; CLU_030752_0_0_1; -.
DR InParanoid; E1BK71; -.
DR OMA; SGQDEEW; -.
DR OrthoDB; 9421at2759; -.
DR TreeFam; TF313677; -.
DR Reactome; R-BTA-8856828; Clathrin-mediated endocytosis.
DR Proteomes; UP000009136; Chromosome 15.
DR Bgee; ENSBTAG00000009576; Expressed in laryngeal cartilage and 104 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005768; C:endosome; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005543; F:phospholipid binding; IBA:GO_Central.
DR GO; GO:0007010; P:cytoskeleton organization; IBA:GO_Central.
DR GO; GO:0097320; P:plasma membrane tubulation; IBA:GO_Central.
DR GO; GO:0030100; P:regulation of endocytosis; IBA:GO_Central.
DR CDD; cd11997; SH3_PACSIN3; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR031160; F_BAR.
DR InterPro; IPR001060; FCH_dom.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR23065; PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1; 1.
DR PANTHER; PTHR23065:SF18; PROTEIN KINASE C AND CASEIN KINASE SUBSTRATE IN NEURONS PROTEIN 3; 1.
DR Pfam; PF00611; FCH; 1.
DR Pfam; PF14604; SH3_9; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00055; FCH; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS51741; F_BAR; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|PROSITE-ProRule:PRU01077};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 10..280
FT /note="F-BAR"
FT /evidence="ECO:0000259|PROSITE:PS51741"
FT DOMAIN 360..421
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 155..185
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 311..355
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 155..172
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 421 AA; 48537 MW; 7A345CFF412E48C4 CRC64;
MAPEEEAGGE ALEGSFWEAG NYRRTVQRVE DGHRLCGDLV SCFQERARIE KAYAQQLADW
ARKWRGAVEK GPQYGTLEKA WHAFFTAAER LSALHLEVRE KLQGQDSERV RSWQRGAFHR
PVLGGFRESR AAEDGFRKAQ KPWLKRLKEV EASKKSYHAA RKEEKTAQTR ESHAKADSAV
SQEQLRKLQE RVERCSKEAE KTKTQYEQSL AELHRYTPRY MEDMEQAFES CQAAERQRLL
FFKDMLLTLH QHLDLSSSER FHELHRDLHR GIEAASDEED LRWWRSTHGP GMAMNWPQFE
EWSLDTQRTI SRKEKGGRSP DEVTLTSIVP TRDGAAPPPQ SPRGRHEEEW SDEENPLKAA
TGVRVRALYD YAGQEADELS FRAGEELLKM SEEDEQGWCQ GQLQSGRIGL YPANYVECVG
A
//
