ID E1BKW9_BOVIN Unreviewed; 1000 AA.
AC E1BKW9;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 3.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=Sorting nexin 19 {ECO:0000313|Ensembl:ENSBTAP00000017386.6};
GN Name=SNX19 {ECO:0000313|Ensembl:ENSBTAP00000017386.6,
GN ECO:0000313|VGNC:VGNC:35099};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000017386.6, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000017386.6, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000017386.6,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000017386.6}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000017386.6};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the sorting nexin family.
CC {ECO:0000256|ARBA:ARBA00010883}.
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DR AlphaFoldDB; E1BKW9; -.
DR SMR; E1BKW9; -.
DR STRING; 9913.ENSBTAP00000017386; -.
DR PaxDb; 9913-ENSBTAP00000017386; -.
DR Ensembl; ENSBTAT00000017386.6; ENSBTAP00000017386.6; ENSBTAG00000013076.6.
DR VEuPathDB; HostDB:ENSBTAG00000013076; -.
DR VGNC; VGNC:35099; SNX19.
DR eggNOG; ENOG502QQBH; Eukaryota.
DR GeneTree; ENSGT00950000182856; -.
DR HOGENOM; CLU_012033_0_0_1; -.
DR InParanoid; E1BKW9; -.
DR OMA; QPSQLWE; -.
DR TreeFam; TF324055; -.
DR Proteomes; UP000009136; Chromosome 29.
DR Bgee; ENSBTAG00000013076; Expressed in prefrontal cortex and 104 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0035091; F:phosphatidylinositol binding; IBA:GO_Central.
DR GO; GO:0002062; P:chondrocyte differentiation; IEA:Ensembl.
DR GO; GO:1990502; P:dense core granule maturation; IEA:Ensembl.
DR GO; GO:0030073; P:insulin secretion; IEA:Ensembl.
DR CDD; cd06893; PX_SNX19; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR InterPro; IPR003114; Phox_assoc.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR037909; SNX19_PX.
DR InterPro; IPR013937; Sorting_nexin_C.
DR PANTHER; PTHR22775; SORTING NEXIN; 1.
DR PANTHER; PTHR22775:SF31; SORTING NEXIN-19; 1.
DR Pfam; PF08628; Nexin_C; 1.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF02194; PXA; 1.
DR SMART; SM00312; PX; 1.
DR SMART; SM00313; PXA; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR PROSITE; PS50195; PX; 1.
DR PROSITE; PS51207; PXA; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT DOMAIN 93..270
FT /note="PXA"
FT /evidence="ECO:0000259|PROSITE:PS51207"
FT DOMAIN 533..663
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
FT REGION 404..433
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 693..725
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 974..1000
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 705..723
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1000 AA; 108915 MW; 6448F6AA6D3AC60A CRC64;
MKTETEILAP ERPAGPGVSH LLSSRKLVAL GAVLGWLLVI HLLVNVWLLC LLSALLLVLG
GWLGSDAIVG ASGRLHLERF IPMAVCPPNP EAERQLEQEI DRTIRMIMRD FVSSWYRTVS
QEPAFEEEME AAMRGLVQEL RRRMARVDSH ALAQRVLTLC GCHLQSYIQA KEAAGKQSGP
GEPSQLWEAY CRASAPHPAV QSPSAEVTYT RGIVNVLLQG LVPKPHLETR TGRHIVVELI
TCNVILPLIS KLSDPDWIHL VLVGIFSKAR TNPAGVANPL CPASALEQPS VPTSLPLIVE
IQGLAEAPSP AAAPVLLSCS EPDGPSHPSP DIEEGHEALE GDLGGVLEER KVENSSSHFL
QPLFLSEDAE LESPLSELSK ETIMLMTPGP FLSASIQDAL CALGGSQPLE PKDGKGPEGI
EGAEAEEGPG TETEPGLLAS MLNSCPEIQI DTADKEGEQG NDACLTTLLP SPERICPPRP
SCLEKDLTNG GSSLDSSLPQ VLLSSSPPGP LSSATFNFES LGSPDGPVVI QNLRITGTIT
AREHSGTGFH PYTLYTVKYE TALDGESSGG LQHVAYHTVN RRYREFLNLQ TRLEEKSDLR
KFIKNVKGPK KLFPDLPFGN MDSDRVEARK SLLESFLKQL CAIPEIANSE EMQEFLALNT
DARIAFVKKP FVVSRIDKMV VSAIVDTLKT AFPRSEPQSP TEELSEAETE NKPQTEGKKA
SKSRLRFSSS KIAPALNITE AHEKVLYCLQ DSGVESETLS VSGMESFIEK QAKLLEVQPA
DAPGRDSEQT AEGCVDGRVS DAAAPAQGLS SSDPGTETEL ADTALDLLVL LLMEQWRWLC
TESVQKVLHL VFGTLIQRWL EVQVAHLTCP QRWVQYLRLL QESIWPGGAL PKCPRPVRTP
EQKAAAEKQA LQSLMGVLPD VIVEILGENK CRLSWSLVLE SLQQPLINRH LIYCLWDIIL
ELLELSASAE ESAVTSSTAD TPGRRASPLS QRPLSRFFEG
//
