ID E1BN69_BOVIN Unreviewed; 1119 AA.
AC E1BN69;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 86.
DE SubName: Full=Leucine rich repeats and immunoglobulin like domains 3 {ECO:0000313|Ensembl:ENSBTAP00000002883.3};
GN Name=LRIG3 {ECO:0000313|Ensembl:ENSBTAP00000002883.3,
GN ECO:0000313|VGNC:VGNC:30984};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000002883.3, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000002883.3, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000002883.3,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000002883.3}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000002883.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; NP_001192520.1; NM_001205591.1.
DR AlphaFoldDB; E1BN69; -.
DR SMR; E1BN69; -.
DR STRING; 9913.ENSBTAP00000002883; -.
DR PaxDb; 9913-ENSBTAP00000002883; -.
DR Ensembl; ENSBTAT00000002883.4; ENSBTAP00000002883.3; ENSBTAG00000002227.5.
DR GeneID; 506574; -.
DR KEGG; bta:506574; -.
DR CTD; 121227; -.
DR VEuPathDB; HostDB:ENSBTAG00000002227; -.
DR VGNC; VGNC:30984; LRIG3.
DR eggNOG; KOG0619; Eukaryota.
DR eggNOG; KOG4194; Eukaryota.
DR GeneTree; ENSGT00940000157098; -.
DR HOGENOM; CLU_000288_18_24_1; -.
DR InParanoid; E1BN69; -.
DR OMA; WIIEDQS; -.
DR OrthoDB; 5405965at2759; -.
DR TreeFam; TF325380; -.
DR Proteomes; UP000009136; Chromosome 5.
DR Bgee; ENSBTAG00000002227; Expressed in oocyte and 102 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0032474; P:otolith morphogenesis; IBA:GO_Central.
DR CDD; cd05763; IgI_LRIG1-like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR45842:SF16; LEUCINE-RICH REPEATS AND IMMUNOGLOBULIN-LIKE DOMAINS 3; 1.
DR PANTHER; PTHR45842; SYNAPTIC ADHESION-LIKE MOLECULE SALM; 1.
DR Pfam; PF07679; I-set; 2.
DR Pfam; PF13927; Ig_3; 1.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF13855; LRR_8; 3.
DR SMART; SM00409; IG; 3.
DR SMART; SM00408; IGc2; 3.
DR SMART; SM00365; LRR_SD22; 7.
DR SMART; SM00369; LRR_TYP; 14.
DR SMART; SM00082; LRRCT; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 3.
DR SUPFAM; SSF52058; L domain-like; 2.
DR PROSITE; PS50835; IG_LIKE; 3.
DR PROSITE; PS51450; LRR; 5.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..1119
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003144246"
FT TRANSMEM 805..831
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 499..598
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 603..692
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 697..783
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 1009..1033
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1070..1119
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1075..1103
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1104..1119
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1119 AA; 123109 MW; CE117453E9960BE8 CRC64;
MGAPRVRALA AALGLLLCEV LGHAGPAEGG GLEALGPPSG VGAEHQCPTP CRCFGDLLDC
SRQRLAHLPE PLPSWIARLD LSHNRLSFIK ASSLSHLHSL REVKLNNNEL ETIPNLGPVT
ANITLLSLAG NKIVEILPEH LRQFQSLETL DLSGNNISEL KTALPPLQLK YLYINSNRVT
SMEPGYFDNL ASTLLVLKLN RNRISALPPK MFKLPQLQHL ELNRNKIKNI DGLTFQGLGA
LKSLKMQRNG VTRLMDGAFW GLSNMEILQL DHNNLTEITK GWLYGLLMLQ ELHLSQNAIS
RISPDAWEFC QKLSELDLTY NHLSRLDDSS FLGLSLLNTL HIGNNRVNYI ADCAFRGLSS
LKTLDLKNNE ISWTIEDMNG AFSGLDKLKR LILQGNRIRS ITKKAFTGLD ALEHLDLSDN
AIMSLQGNAF SQMKKLQQLH LNTSSLLCDC QLKWLPQWVA ENNFQSFVNA SCAHPQLLKG
RSIFAVSPDG FVCDDFPKPQ ITVQPETQSA IKGSNLSFIC SAASSSDSPM TFAWKKDNEL
LHDAEMENYA HLRAQGGEVM EYTTILRLRN VEFTSEGKYQ CVISNHFGSS YSVKAKLTVN
MLPSFTKTPM DLTIRAGAMA RLECAALGHP APQIAWQKDG GTDFPAARER RMHVMPEDDV
FFIVDVKIED IGVYSCTAQN SAGSISANAT LTVLETPSFL RPLLDRTVTK GETAVLQCIA
GGSPPPRLNW TKDDSPLVVT ERHFFAAGNQ LLIIVDSDIS DAGKYTCEMS NTLGTERGHV
RLSVIPTPTC DSPQMTASSL DDDGWATVGI VIIAVVCCVV GTSLVWVVII YHTRRRNEDC
SITNTDETNL PADIPSYLSS QGTLADRQDG YISSENGSHH QFVTSSGGGF FLPQHDSNGT
CHIDNSSEAD VEAATDPFLC PFLGPSGPVY LKGSVYGSDP FEAYHTGCGP DLRSALMDHY
EPSYIKKKEC YPCPHPSEES CEQSVSDTGW PSHAKKLLSS SYSQHEGPGM NNLCLNKSSA
DFSPSPEPPS VTLSNSFMGT FGKPLRRPHL DAFSSSGQSS DCQPRAFHLK ARSSPNLDYE
SEEDGKERTD FQQENHTCTH KQTLESHRTS NFQSFDLDT
//
