ID E1BPU3_BOVIN Unreviewed; 1281 AA.
AC E1BPU3;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 2.
DT 24-JAN-2024, entry version 85.
DE RecName: Full=Peroxisomal ATPase PEX1 {ECO:0000256|ARBA:ARBA00034532};
DE AltName: Full=Peroxin-1 {ECO:0000256|ARBA:ARBA00032509};
GN Name=PEX1 {ECO:0000313|Ensembl:ENSBTAP00000033778.4,
GN ECO:0000313|VGNC:VGNC:32751};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000033778.4, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000033778.4, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000033778.4,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000033778.4}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000033778.4};
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216;
CC Evidence={ECO:0000256|ARBA:ARBA00034440};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13066;
CC Evidence={ECO:0000256|ARBA:ARBA00034440};
CC -!- SIMILARITY: Belongs to the AAA ATPase family.
CC {ECO:0000256|ARBA:ARBA00006914}.
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DR SMR; E1BPU3; -.
DR STRING; 9913.ENSBTAP00000033778; -.
DR PaxDb; 9913-ENSBTAP00000033778; -.
DR Ensembl; ENSBTAT00000033872.5; ENSBTAP00000033778.4; ENSBTAG00000024431.5.
DR VEuPathDB; HostDB:ENSBTAG00000024431; -.
DR VGNC; VGNC:32751; PEX1.
DR eggNOG; KOG0735; Eukaryota.
DR GeneTree; ENSGT00550000075032; -.
DR HOGENOM; CLU_000688_1_1_1; -.
DR InParanoid; E1BPU3; -.
DR OMA; QGFVNIQ; -.
DR TreeFam; TF106447; -.
DR Reactome; R-BTA-9033241; Peroxisomal protein import.
DR Proteomes; UP000009136; Chromosome 4.
DR Bgee; ENSBTAG00000024431; Expressed in liver and 105 other cell types or tissues.
DR ExpressionAtlas; E1BPU3; baseline and differential.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005778; C:peroxisomal membrane; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:Ensembl.
DR GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR GO; GO:0140318; F:protein transporter activity; IEA:Ensembl.
DR GO; GO:0044877; F:protein-containing complex binding; IEA:Ensembl.
DR GO; GO:0140036; F:ubiquitin-dependent protein binding; IEA:Ensembl.
DR GO; GO:0060152; P:microtubule-based peroxisome localization; IEA:Ensembl.
DR GO; GO:0016558; P:protein import into peroxisome matrix; IBA:GO_Central.
DR GO; GO:0016562; P:protein import into peroxisome matrix, receptor recycling; IEA:Ensembl.
DR GO; GO:0043335; P:protein unfolding; IEA:Ensembl.
DR CDD; cd19526; RecA-like_PEX1_r2; 1.
DR Gene3D; 1.10.8.60; -; 2.
DR Gene3D; 2.40.40.20; -; 1.
DR Gene3D; 3.10.330.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR041569; AAA_lid_3.
DR InterPro; IPR009010; Asp_de-COase-like_dom_sf.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR003960; ATPase_AAA_CS.
DR InterPro; IPR029067; CDC48_domain_2-like_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015343; PEX1-N-lobe.
DR InterPro; IPR015342; PEX1-N_C-lobe.
DR PANTHER; PTHR23077; AAA-FAMILY ATPASE; 1.
DR PANTHER; PTHR23077:SF12; PEROXISOME BIOGENESIS FACTOR 1; 1.
DR Pfam; PF00004; AAA; 2.
DR Pfam; PF17862; AAA_lid_3; 1.
DR Pfam; PF09262; PEX-1N; 1.
DR Pfam; PF09263; PEX-2N; 1.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF50692; ADC-like; 1.
DR SUPFAM; SSF54585; Cdc48 domain 2-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00674; AAA; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 590..740
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 872..1008
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 345..373
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1140..1173
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1259..1281
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 351..373
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1140..1162
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1281 AA; 142149 MW; 31109096D2256D96 CRC64;
MWGSGRLAGS GGGAAVTVAF TNARDCFLHL PRRLVAQLHL LQNQAIEVAW GHQPAFLSWV
EGRHFSDEGE NVAEINRQVG QKLGLSNGAQ VFLKPCSHVV SCQQVEVEPL SADDWEILEL
HAASLEQHLL DQIRIVFPKA IFPVWVDQQT YIFIQIAALI PDAPYGRLET DSRLLIQPKT
RQAKESTFSE AEDIPGKFHH YGRDQKGLTK ELQTKQLQSN TVGVAGSKER ESEGRIDSSF
IPSLWTMIGS IFSSGSEKKR DTSWGLTEVN AFKNMQSAVV PLDNIFRVCK SQPPSMCKAS
ATSVFHKHYA IHVFPWDQEY FDVEPSFTVT YGKLVKLLSP KQQQSRTKQN VLSPEKEKQM
SEPLDQKQVS PDHSHKAGKA CVLKVVWNGL EELKNAIKYT KNLDVLHLGK VWIPHDLRKR
LNIEMHAVVR ITPVEITPNI PRSLKLQPTE NLSEDVSEED IKTVFYSWLQ QSATTAVPLI
VSEEEYIKLE MKDGVKEFSL NIVHSWEKEK EENIFLLSTN LLQKMTIQVL LDPMVKEENS
EEIDFILPFL KLNCLGGVNS LGVSSMEHIT HSLLGRPLSR QLVSLVAGLR NGALLLTGGK
GSGKSTLAKA ICKEAFDILD AHVEIIDCKA LRGKRLENIQ KTLAAAFSEA LWRQPSVVLL
DDLDLVVGRS ALPEHEHSPE AIQSQRLAHA LNDLVKEFIS MGSLVALIAT SQSQHSLHPL
LVSAQGIHIF QCVQHIQPPD QDQRCEILHA IIKNKLDCDM KRFTGLDLQR IAKETEGFVA
RDFTMLVDRA IHSHLSHQNV YTREELVLTT LDFQKALRGF TPVSLRNVNL HKPRDLGWDR
IGGLHDVRQI LVDTIQLPAK YPELFANLPI RQRTGVLLYG PPGTGKTLLA GVIARESGMN
FISVKGPELL SKYIGASEQA VRDVFVRAQA AKPCILFFDE FESIAPRRGH DNTGVTDRVV
NQLLTQLDGV EGLQGVYVLA ATSRPDLIDP ALLRPGRLDK CVYCPPPDQA SRLEILNVLS
ESLPLADDVD LQHVASLTDS FTGADLKALL YGAQLEALHG RLLTGGLQDG GSSSDSDLSL
SSMVFLNHSS GSDDSAGDGE CGLEQSLVSL EMSEVLQDES KFNMYRLYFG SSYESELGNG
TSSDLSSQCL SAPSSMTQEF PGAPGKDQSL RPPLFRTASQ EGYQELTQEQ RDQLRADISI
IKGRYRSQTG EDDALNPPGP SKTSLAISQS HLMTALSHTR PSISEDDWKT FAELYESFQN
PKKRKNQSGT VFRPGQKVTL A
//